Advancing Upper Gastrointestinal Cancer Detection: A Single-Center Pilot Study Exploring the Potential of Electrical Impedance Spectroscopy in Endoscopic Procedures.
| Title: | Advancing Upper Gastrointestinal Cancer Detection: A Single-Center Pilot Study Exploring the Potential of Electrical Impedance Spectroscopy in Endoscopic Procedures. |
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| Authors: | Dowlatabad HM; Nano Bioelectronics Devices Lab (NBEL), Cancer Electronics Research Group, School of Electrical and Computer Engineering, Faculty of Engineering, University of Tehran, P.O. Box, Tehran, 14399-57131, Iran.; Mahdavi R; Nano Bioelectronics Devices Lab (NBEL), Cancer Electronics Research Group, School of Electrical and Computer Engineering, Faculty of Engineering, University of Tehran, P.O. Box, Tehran, 14399-57131, Iran.; UT&TUMS Cancer Electronics Research Center, University of Tehran, P.O. Box: 14395/515, Tehran, Iran.; Miri SR; UT&TUMS Cancer Electronics Research Center, University of Tehran, P.O. Box: 14395/515, Tehran, Iran.; Department of Surgical Oncology, Cancer Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, P.O. Box: 1419733141, Tehran, Iran.; Fattahi MR; UT&TUMS Cancer Electronics Research Center, University of Tehran, P.O. Box: 14395/515, Tehran, Iran.; Department of Surgical Oncology, Cancer Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, P.O. Box: 1419733141, Tehran, Iran.; Student Research Committee, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.; Ataee H; Nano Bioelectronics Devices Lab (NBEL), Cancer Electronics Research Group, School of Electrical and Computer Engineering, Faculty of Engineering, University of Tehran, P.O. Box, Tehran, 14399-57131, Iran.; Yousefpour N; Nano Bioelectronics Devices Lab (NBEL), Cancer Electronics Research Group, School of Electrical and Computer Engineering, Faculty of Engineering, University of Tehran, P.O. Box, Tehran, 14399-57131, Iran.; Manoochehri N; Nano Bioelectronics Devices Lab (NBEL), Cancer Electronics Research Group, School of Electrical and Computer Engineering, Faculty of Engineering, University of Tehran, P.O. Box, Tehran, 14399-57131, Iran.; Taslimi R; Department of Gastroenterology, School of Medicine, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, 1419733141, Tehran, Iran.; Abdolahad M; Nano Bioelectronics Devices Lab (NBEL), Cancer Electronics Research Group, School of Electrical and Computer Engineering, Faculty of Engineering, University of Tehran, P.O. Box, Tehran, 14399-57131, Iran. m.abdolahad@ut.ac.ir.; Department of Surgical Oncology, Cancer Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, P.O. Box: 1419733141, Tehran, Iran. m.abdolahad@ut.ac.ir. |
| Source: | Digestive diseases and sciences [Dig Dis Sci] 2025 Jul; Vol. 70 (7), pp. 2433-2443. Date of Electronic Publication: 2025 Apr 05. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Springer Science + Business Media Country of Publication: United States NLM ID: 7902782 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2568 (Electronic) Linking ISSN: 01632116 NLM ISO Abbreviation: Dig Dis Sci Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2005- : New York, NY : Springer Science + Business Media; Original Publication: New York, Plenum Pub. Corp. |
| MeSH Terms: | Dielectric Spectroscopy*/instrumentation ; Dielectric Spectroscopy*/methods ; Gastrointestinal Neoplasms*/diagnosis ; Gastrointestinal Neoplasms*/pathology ; Endoscopy, Gastrointestinal*/methods ; Endoscopy, Gastrointestinal*/instrumentation ; Early Detection of Cancer*/methods ; Early Detection of Cancer*/instrumentation; Humans ; Pilot Projects ; Female ; Male ; Middle Aged ; Aged ; Biopsy ; Sensitivity and Specificity ; Aged, 80 and over |
| Abstract: | Purpose: Early detection of GI cancer mass is of utmost importance due to the risks of misdiagnoses that occur through standard endoscopic evaluation.; Methods: In this research, a real-time intra-endoscopic electrical diagnostic probe has been introduced to discriminate high-risk excision-required lesions utilizing a modified endoscopic biopsy forceps as a non-invasive method.; Results: By testing on 52 patients who had undergone endoscopic biopsy with a total of 18 high-risk lesions, the invented device named Electrical Endoscopic Mass Characterizer (EEMC), showed %94.7 sensitivity, %93.9 specificity, and %94.2 accuracy (p |
| Competing Interests: | Declarations. Conflict of interest: The authors declare no competing interests. Ethical approval: This project adheres to the ethical guidelines set forth by the World Medical Association Ethics, Declaration of Helsinki, and the national standards for Medical Research in Iran. All human tests were conducted with the approval of the Ethics Committee of Tehran University of Medical, under the license granted by the Institutional Review Board (IRB) or Research Ethics Committee (REC) with the written consent for each participant. The clinical trial registration number for this project is I.R.TUMS.VCR.REC.1398.892. |
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| Contributed Indexing: | Keywords: Biopsy forceps; Dysplasia; Electrical impedance spectroscopy; Endoscopy; Gastrointestinal cancers; Impedance phase slope; Intestinal metaplasia |
| Entry Date(s): | Date Created: 20250405 Date Completed: 20250725 Latest Revision: 20250725 |
| Update Code: | 20260130 |
| DOI: | 10.1007/s10620-025-08983-3 |
| PMID: | 40186830 |
| Database: | MEDLINE |
Journal Article