Comparison of autograft and allograft outcomes in adolescent ACL reconstruction: a propensity score analysis.
| Title: | Comparison of autograft and allograft outcomes in adolescent ACL reconstruction: a propensity score analysis. |
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| Authors: | Screpis D; IRCCS Ospedale Sacro Cuore Don Calabria, Department of Orthopaedics, Negrar di Valpolicella, Italy.; De Berardinis L; IRCCS Ospedale San Raffaele, Orthopaedic and Trauma Unit, Milano, Italy.; Qordja F; Università Politecnica delle Marche, Clinic of Orthopaedics, Department of Clinical and Molecular Sciences, Ancona, Italy. qordja.fjorela@gmail.com.; Piovan G; IRCCS Ospedale Sacro Cuore Don Calabria, Department of Orthopaedics, Negrar di Valpolicella, Italy.; Giannini E; Kinetic Center, Pisa, Italy.; Gigante AP; Università Politecnica delle Marche, Clinic of Orthopaedics, Department of Clinical and Molecular Sciences, Ancona, Italy.; IRCCS Istituto Nazionale di Ricovero e Cura per Anziani, Ancona, Italy.; Zorzi C; IRCCS Ospedale Sacro Cuore Don Calabria, Department of Orthopaedics, Negrar di Valpolicella, Italy. |
| Source: | European journal of orthopaedic surgery & traumatology : orthopedie traumatologie [Eur J Orthop Surg Traumatol] 2025 Apr 06; Vol. 35 (1), pp. 149. Date of Electronic Publication: 2025 Apr 06. |
| Publication Type: | Journal Article; Comparative Study |
| Language: | English |
| Journal Info: | Publisher: Springer-Verlag France Country of Publication: France NLM ID: 9518037 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-1068 (Electronic) Linking ISSN: 16338065 NLM ISO Abbreviation: Eur J Orthop Surg Traumatol Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Paris : Springer-Verlag France |
| MeSH Terms: | Anterior Cruciate Ligament Reconstruction*/methods ; Anterior Cruciate Ligament Reconstruction*/adverse effects ; Anterior Cruciate Ligament Injuries*/surgery ; Hamstring Tendons*/transplantation; Transplantation, Autologous/adverse effects ; Reoperation/statistics & numerical data ; Transplantation, Homologous/adverse effects ; Humans ; Adolescent ; Male ; Propensity Score ; Female ; Autografts ; Allografts ; Graft Survival ; Retrospective Studies ; Treatment Outcome |
| Abstract: | Purpose: To assess 3-year clinical and functional outcomes, complication rates and graft survival in adolescents with closed growth plates subjected to primary unilateral anterior cruciate ligament reconstruction (ACLR) with a hamstring autograft or an allograft. The failure rate reported in the literature reaches up to 20%.; Methods: We reviewed the records of 170 patients subjected to ACLR with a single-bundle autograft or an allograft from 2017 to 2020 with 3-year follow-up. Application of 1:2 Propensity Score Matching (PSM) considering age, sex, body mass index, injury to surgery interval, graft diameter and pre-injury Tegner Activity Scale (TAS) scores and Lysholm Knee Score (LKS) yielded 38 allografts and 62 autografts. We compared functional outcomes using the TAS, LKS and International Knee Documentation Committee (IKDC) at 18 and 36 months and the failure rates, defined as need for revision surgery, before and after PSM.; Results: Mean age ranged from 15.8 (standard deviation [SD], 1.2) to 15.9 (SD, 0.9) years and the pre-injury TAS ranged from 7.3 (SD, 1.0) to 7.3 (SD, 1.2) in allograft and autograft patients, respectively. Analysis of the LKS, TAS and IKDC values demonstrated comparable levels both before and after PSM, except for the pre-matching IKDC score and the post-matching TAS score at 36 months, which were significantly higher in autograft than allograft patients (p = 0.024 and p = 0.039, respectively). As regards graft failure, before PSM significantly more allografts (12/54) than autografts (5/116) required revision surgery (p |
| Competing Interests: | Declarations. Competing interests: The Authors have no competing interests to declare that are relevant to the content of this article. Ethics approval: The study complies with the guidelines outlined in the 2013 revised Declaration of Helsinki and was approved by institutional review committee. Consent statement: Informed consent for participation in the study was obtained from patients or the minors’ parents/guardians. Data, materials and/or code availability statement: Data are available upon reasonable request. |
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| Contributed Indexing: | Keywords: ACLR; Adolescents; Allograft; Anterior cruciate ligament reconstruction; Autograft; Propensity score matching |
| Entry Date(s): | Date Created: 20250406 Date Completed: 20250406 Latest Revision: 20260101 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC11972989 |
| DOI: | 10.1007/s00590-025-04244-1 |
| PMID: | 40188407 |
| Database: | MEDLINE |
Journal Article; Comparative Study