Differential Association of Regional Adipose Tissue Deposit with Cardiovascular-Kidney-Metabolic Syndrome.
| Title: | Differential Association of Regional Adipose Tissue Deposit with Cardiovascular-Kidney-Metabolic Syndrome. |
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| Authors: | Cho IJ; Division of Cardiology, Department of Internal Medicine, Ewha Womans University Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea.; Lee SE; Division of Cardiology, Department of Internal Medicine, Ewha Womans University Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea.; Pyun WB; Division of Cardiology, Department of Internal Medicine, Ewha Womans University Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea. |
| Source: | Cardiorenal medicine [Cardiorenal Med] 2025; Vol. 15 (1), pp. 285-294. Date of Electronic Publication: 2025 Apr 10. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Karger Country of Publication: Switzerland NLM ID: 101554863 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1664-5502 (Electronic) Linking ISSN: 16645502 NLM ISO Abbreviation: Cardiorenal Med Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Basel : Karger |
| MeSH Terms: | Metabolic Syndrome*/physiopathology ; Metabolic Syndrome*/diagnosis ; Adipose Tissue*/diagnostic imaging ; Cardio-Renal Syndrome*/physiopathology; Echocardiography/methods ; Ventricular Function, Left/physiology ; Humans ; Male ; Female ; Middle Aged ; Retrospective Studies ; Aged ; Glomerular Filtration Rate ; Tomography, X-Ray Computed ; Disease Progression |
| Abstract: | Introduction: Cardiovascular-kidney-metabolic (CKM) syndrome is a condition characterized by the interplay between cardiovascular disease, kidney disease, diabetes, and obesity, resulting in adverse health outcomes. This study aimed to investigate the differential associations between various adipose tissue types and the progression of CKM syndrome, as well as their relationship with the individual components of the syndrome.; Methods: We conducted a retrospective review of 441 individuals with preserved left ventricular (LV) systolic function who underwent both transthoracic echocardiography and abdominal computed tomography. LV structural and functional parameters, along with the thickness of epicardial adipose tissue (EAT), perirenal adipose tissue (PAT), and subcutaneous adipose tissue (SAT), were assessed through these imaging modalities. Additionally, the triglyceride and glucose (TyG) index was evaluated as a marker of insulin resistance, while glomerular filtration rate (GFR) was estimated to assess kidney function.; Results: EAT and PAT demonstrated a progressive increase in thickness with advancing stages of CKM syndrome, whereas body mass index and SAT did not show similar trends. EAT was predominantly associated with markers of LV diastolic dysfunction, while PAT was uniquely associated with GFR, independent of other adipose tissue. Furthermore, the TyG index was independently correlated with the thickness of both EAT and PAT, but not with SAT thickness.; Conclusion: Heart, kidney, and metabolic disorders associated with CKM syndrome demonstrated varying correlations depending on the specific regional adipose tissue depot. EAT and PAT were identified as key regional adipose tissue linked to the progression of CKM syndrome.; (© 2025 The Author(s). Published by S. Karger AG, Basel.) |
| Contributed Indexing: | Keywords: Adipose tissue; Cardiovascular disease; Kidney disease; Metabolic disorder |
| Entry Date(s): | Date Created: 20250410 Date Completed: 20250518 Latest Revision: 20250518 |
| Update Code: | 20260130 |
| DOI: | 10.1159/000545802 |
| PMID: | 40209693 |
| Database: | MEDLINE |
Journal Article