Unveiling the therapeutic potential: anti-inflammatory and antioxidant properties of selective medicinal plants.
| Title: | Unveiling the therapeutic potential: anti-inflammatory and antioxidant properties of selective medicinal plants. |
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| Authors: | Krayem N; Laboratory of Biochemistry and Enzymatic Engineering of Lipases, ENIS, University of Sfax, Soukra Road, BP1171, Sfax 3038, Tunisia. krayemnajeh@yahoo.fr.; Jribi F; Laboratory of Biochemistry and Enzymatic Engineering of Lipases, ENIS, University of Sfax, Soukra Road, BP1171, Sfax 3038, Tunisia. jribi.farah@gmail.com.; Alonazi M; Department of Biochemistry, College of Science, King Saud University, P.O. Box 22452, Riyadh 11495, Saudi Arabia. moalonazi@ksu.edu.sa.; Amina M; Department of Pharmacognosy, Pharmacy College, King Saud University, Riyadh 11495, Saudi Arabia. mamina@KSU.EDU.SA.; Horchani H; Science Department, Environmental and Biotechnology Research Group, College of Rivière-Du-Loup, Rivière-Du-Loup, QC G5R 1R1, Canada. habib.horchani@cegeprdl.ca.; Karray A; Laboratory of Biochemistry and Enzymatic Engineering of Lipases, ENIS, University of Sfax, Soukra Road, BP1171, Sfax 3038, Tunisia. aida.karray@enis.tn.; Cherif S; Laboratory of Biochemistry and Enzymatic Engineering of Lipases, ENIS, University of Sfax, Soukra Road, BP1171, Sfax 3038, Tunisia. slimcherif_enis@yahoo.fr.; Ben Bacha A; Department of Biochemistry, College of Science, King Saud University, P.O. Box 22452, Riyadh 11495, Saudi Arabia. aalghanouchi@ksu.edu.sa. |
| Source: | Cellular and molecular biology (Noisy-le-Grand, France) [Cell Mol Biol (Noisy-le-grand)] 2025 Apr 15; Vol. 71 (3), pp. 88-100. Date of Electronic Publication: 2025 Apr 15. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: C.M.B. Association Country of Publication: France NLM ID: 9216789 Publication Model: Electronic Cited Medium: Internet ISSN: 1165-158X (Electronic) Linking ISSN: 01455680 NLM ISO Abbreviation: Cell Mol Biol (Noisy-le-grand) Subsets: MEDLINE |
| Imprint Name(s): | Publication: : Noisy-Le-Grand, France : C.M.B. Association; Original Publication: Noisy-le-Grand, France : R. Wegmann, 1992- |
| MeSH Terms: | Anti-Inflammatory Agents*/pharmacology ; Anti-Inflammatory Agents*/chemistry ; Antioxidants*/pharmacology ; Antioxidants*/chemistry ; Plant Extracts*/pharmacology ; Plant Extracts*/chemistry ; Plants, Medicinal*/chemistry; Flavonoids/pharmacology ; Flavonoids/chemistry ; Flavonoids/analysis ; Phenols/pharmacology ; Phenols/chemistry ; Phenols/analysis ; Anti-Infective Agents/pharmacology ; Artemisia/chemistry ; Microbial Sensitivity Tests ; Humans ; Chromatography, High Pressure Liquid |
| Abstract: | This study highlights the potential of plant extracts as sustainable and cost-effective alternatives to traditional anti-inflammatory drugs, owing to their rich bioactive compounds. The chemical composition and biological activities of ethanolic extracts from Artemisia campestris, Haloxylon articulatum, and Retama raetam were investigated. Extraction yields ranged from 2.94% to 6.84%, with A. campestris showing the highest phenolic content (85.59 ± 2.4 mg GAE/g) and R. raetam having the highest flavonoid concentration (34.77 ± 3.09 mg CE/g). HPLC analysis identified therapeutic phenolic and flavonoid compounds, including sinapic, quinic, and caffeic acids in A. campestris, p-coumaric acid in H. articulatum, and salicylic acid in R. raetam. Antimicrobial tests revealed that Gram-positive bacteria like Staphylococcus aureus and Bacillus cereus were sensitive to the extracts, though Gram-negative strains were unaffected. Antifungal activity was limited, with only H. articulatum showing inhibition of Rhizoctonia solani. Strong antioxidant activities were noted, particularly in H. articulatum and R. raetam extracts (IC50 = 130 µg/mL). In anti-inflammatory assays, all extracts exhibited dose-dependent inhibition of enzymes linked to inflammation, including COX-1, COX-2, 5-LOX, and sPLA2. A. campestris demonstrated the most potent inhibition, reaching 100% inhibition of sPLA2 at 200 μg/mL, while A. campestris and R. raetam provided significant protection in human red blood cell membrane stabilization assays. These results suggest that these plant extracts have considerable biological potential, especially in enzyme inhibition related to inflammation, making them promising candidates for future therapeutic use. |
| Substance Nomenclature: | 0 (Anti-Inflammatory Agents); 0 (Antioxidants); 0 (Plant Extracts); 0 (Flavonoids); 0 (Phenols); 0 (Anti-Infective Agents) |
| Entry Date(s): | Date Created: 20250416 Date Completed: 20250416 Latest Revision: 20250416 |
| Update Code: | 20260130 |
| DOI: | 10.14715/cmb/2025.71.3.11 |
| PMID: | 40235328 |
| Database: | MEDLINE |
Journal Article