Computed Tomography Cardiac Angiography Findings in Patients With Sheehan Syndrome.
| Title: | Computed Tomography Cardiac Angiography Findings in Patients With Sheehan Syndrome. |
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| Authors: | Mohammad A; Department of Radiology, Superspeciality Hospital Government Medical College Srinagar, Srinagar, Jammu and Kashmir, India.; Jehangir M; Department of Radiology, Superspeciality Hospital Government Medical College Srinagar, Srinagar, Jammu and Kashmir, India.; Mir SA; Department of Endocrinology, Superspeciality Hospital Government Medical College Srinagar, Srinagar, Jammu and Kashmir, India. Electronic address: mirdrshani@gmail.com.; Fatima SA; Department of Radiology, Superspeciality Hospital Government Medical College Srinagar, Srinagar, Jammu and Kashmir, India.; Baba MS; Department of Endocrinology, Superspeciality Hospital Government Medical College Srinagar, Srinagar, Jammu and Kashmir, India.; Laway BA; Department of Endocrinology, Paras Hospital, Srinagar, Srinagar, Jammu and Kashmir, India.; Bhat JA; Department of Medicine, Government Medical College Handwara, Handwara, Jammu and Kashmir, India.; Nadia Shafi; Department of Transfusion Medicine, Government Medical College Srinagar, Srinagar, Jammu and Kashmir, India. |
| Source: | Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists [Endocr Pract] 2025 Jul; Vol. 31 (7), pp. 913-917. Date of Electronic Publication: 2025 Apr 15. |
| Publication Type: | Journal Article; Observational Study |
| Language: | English |
| Journal Info: | Publisher: Elsevier Inc Country of Publication: United States NLM ID: 9607439 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1530-891X (Print) Linking ISSN: 1530891X NLM ISO Abbreviation: Endocr Pract Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2021- : [New York] : Elsevier Inc.; Original Publication: Jacksonville, Fla. : The College and the Association |
| MeSH Terms: | Hypopituitarism*/complications ; Hypopituitarism*/diagnostic imaging ; Hypopituitarism*/epidemiology ; Coronary Artery Disease*/diagnostic imaging ; Coronary Artery Disease*/epidemiology ; Computed Tomography Angiography*; Plaque, Atherosclerotic/diagnostic imaging ; Vascular Calcification/diagnostic imaging ; Humans ; Female ; Middle Aged ; Cross-Sectional Studies ; Adult ; Coronary Angiography ; Aged |
| Abstract: | Objective: Sheehan Syndrome (SS), or postpartum pituitary necrosis, is associated with an elevated risk of atherosclerotic cardiovascular (CV) diseases, driven by factors such as dyslipidemia, chronic inflammation, and growth hormone deficiency. To better understand the prevalence and characteristics of atherosclerotic CV disease in this population, we conducted a noninvasive evaluation of the coronary arteries using computed tomography cardiac angiography.; Methods: This observational cross-sectional study included women diagnosed with SS who were receiving standard replacement therapy including thyroxine and glucocorticoids. All participants underwent computed tomography cardiac angiography to identify the presence of coronary artery plaques.; Results: The study included 30 patients with SS, with a mean age of 54.20 ± 8.27 years and a mean duration of pituitary disease of 22.67 ± 6.27 years. Coronary artery calcium (CAC) scoring revealed the following risk stratification for coronary artery disease: minimal risk (CAC 1-10) in 6.7% (n = 2), mild risk (CAC 11-100) in 16.7% (n = 5), and moderate risk (CAC 101-400) in 3.3% (n = 1). Coronary artery plaques were identified in 23.3% (n = 7) of patients. Among these, 4 patients had noncalcified plaques, 2 had calcified plaques, and 1 patient had both calcified and noncalcified plaques. A strong positive correlation was observed between CAC scores and percentage stenosis (r = 0.96, P = .01).; Conclusion: Approximately one-fourth of patients with SS were found to have atherosclerotic plaques in their coronary arteries, highlighting their increased susceptibility to CV morbidity and mortality.; (Copyright © 2025 AACE. Published by Elsevier Inc. All rights reserved.) |
| Competing Interests: | Disclosure The authors have no conflicts of interest to disclose. |
| Contributed Indexing: | Keywords: CT angiography; coronary artery disease; coronary calcification; sheehan syndrome |
| Entry Date(s): | Date Created: 20250417 Date Completed: 20250709 Latest Revision: 20250710 |
| Update Code: | 20260130 |
| DOI: | 10.1016/j.eprac.2025.04.006 |
| PMID: | 40246232 |
| Database: | MEDLINE |
Journal Article; Observational Study