Assessing the Big Five personality traits in presymptomatic and symptomatic C9orf72-related frontotemporal dementia using the Dutch Personality Inventory for DSM-5 (PID-5-NL).
| Title: | Assessing the Big Five personality traits in presymptomatic and symptomatic C9orf72-related frontotemporal dementia using the Dutch Personality Inventory for DSM-5 (PID-5-NL). |
|---|---|
| Authors: | Jiskoot LC; Department of Neurology and Alzheimer Centre, Erasmus MC University Medical Centre, Rotterdam, the Netherlands; Dementia Research Centre, University College London, London, United Kingdom. Electronic address: l.c.jiskoot@erasmusmc.nl.; Gouw C; Department of Psychiatry, Erasmus MC University Medical Centre, Rotterdam, the Netherlands.; Coesmans M; Department of Psychiatry, Erasmus MC University Medical Centre, Rotterdam, the Netherlands.; Poos JM; Department of Neurology and Alzheimer Centre, Erasmus MC University Medical Centre, Rotterdam, the Netherlands.; Swartenbroekx T; Department of Neurology and Alzheimer Centre, Erasmus MC University Medical Centre, Rotterdam, the Netherlands.; de Houwer J; Department of Neurology and Alzheimer Centre, Erasmus MC University Medical Centre, Rotterdam, the Netherlands.; Dopper EGP; Department of Neurology and Alzheimer Centre, Erasmus MC University Medical Centre, Rotterdam, the Netherlands.; Donker Kaat L; Department of Clinical Genetics, Erasmus MC University Medical Centre, Rotterdam, the Netherlands.; Boesjes P; Department of Neurology and Alzheimer Centre, Erasmus MC University Medical Centre, Rotterdam, the Netherlands.; de Boer L; Department of Neurology and Alzheimer Centre, Erasmus MC University Medical Centre, Rotterdam, the Netherlands.; van den Berg E; Department of Neurology and Alzheimer Centre, Erasmus MC University Medical Centre, Rotterdam, the Netherlands.; Seelaar H; Department of Neurology and Alzheimer Centre, Erasmus MC University Medical Centre, Rotterdam, the Netherlands. |
| Source: | Journal of the neurological sciences [J Neurol Sci] 2025 Jun 15; Vol. 473, pp. 123502. Date of Electronic Publication: 2025 Apr 11. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0375403 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5883 (Electronic) Linking ISSN: 0022510X NLM ISO Abbreviation: J Neurol Sci Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Amsterdam : Elsevier, |
| MeSH Terms: | C9orf72 Protein*/genetics ; Frontotemporal Dementia*/genetics ; Frontotemporal Dementia*/psychology ; Frontotemporal Dementia*/diagnosis ; Personality Inventory* ; Personality*; DNA Repeat Expansion/genetics ; Humans ; Male ; Female ; Middle Aged ; Aged ; Neuropsychological Tests ; Adult ; Netherlands |
| Abstract: | Background: C9orf72 is one of the leading causes of genetic FTD. Although neuropsychiatric symptoms are considered a distinctive hallmark, no studies into maladaptive premorbid personality traits have been performed in C9orf72-FTD thus far.; Methods: We investigated differences in self-reported and informant-reported brief version of the Dutch Personality Inventory for the DSM (PID-5-NL) in symptomatic (n = 7) and presymptomatic C9orf72 repeat expansion carriers (C9orf72-REC) (n = 27), and controls (n = 18). We also explored relationships with cognitive performance and neuropsychiatric questionnaires (BDI-II-NL and NPI-Q).; Results: Informants of symptomatic C9orf72-REC reported higher total, Disinhibition and Psychoticism scores on the PID-5-NL than presymptomatic C9orf72-REC and controls. No significant differences were found between presymptomatic C9orf72 repeat expansion carriers and controls. There were no significant correlations between the Mini-Mental State Examination and Frontal Assessment Battery total scores and the PID-5-NL scores. In presymptomatic C9orf72-REC, PID-5-BF-NL total, Negative Affect, and Antagonism scores correlated with the BDI-II-NL. PID-5-IBF-NL total and Negative Affect, Antagonism, and Disinhibition scores correlated with the NPI-Q, Disinhibition correlated with the Frontal-Behavioural cluster, and Negative Affect, Antagonism, and Disinhibition correlated with the Mood and Psychotic clusters.; Conclusion: Our findings suggests that the PID-5-BF-NL offers a valuable insight into the presence of maladaptive premorbid personality traits in the symptomatic phase of C9orf72-FTD.; (Copyright © 2024. Published by Elsevier B.V.) |
| Competing Interests: | Declaration of competing interest The authors have no competing interests to declare that are relevant to the content of this article. |
| Contributed Indexing: | Keywords: C9orf72 repeat expansion; Genetic frontotemporal dementia; Neuropsychiatric symptoms; Premorbid personality traits; Presymptomatic |
| Substance Nomenclature: | 0 (C9orf72 Protein); 0 (C9orf72 protein, human) |
| Entry Date(s): | Date Created: 20250419 Date Completed: 20250522 Latest Revision: 20260506 |
| Update Code: | 20260507 |
| DOI: | 10.1016/j.jns.2025.123502 |
| PMID: | 40252388 |
| Database: | MEDLINE |
Journal Article