Treatment outcome and determinant factors of bacterial meningitis at pediatric ward: a multicenter study from Northwest Ethiopia.
| Title: | Treatment outcome and determinant factors of bacterial meningitis at pediatric ward: a multicenter study from Northwest Ethiopia. |
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| Authors: | Siraj EA; Department of Pharmaceutics, School of Pharmacy, College of Medicine and Health Science, Bahir Dar University, Bahir Dar, Ethiopia. ibrahim.abdela2008@gmaill.com.; Tebikew M; Department of Pharmaceutics, School of Pharmacy, College of Medicine and Health Science, Bahir Dar University, Bahir Dar, Ethiopia.; Abay H; Department of Pharmaceutics, School of Pharmacy, College of Medicine and Health Science, Bahir Dar University, Bahir Dar, Ethiopia.; Kebede SY; Department of Pharmacognosy, School of Pharmacy, College of Medicine and Health Science, Bahir Dar University, Bahir Dar, Ethiopia.; Tafere C; Department of Pharmaceutics, School of Pharmacy, College of Medicine and Health Science, Bahir Dar University, Bahir Dar, Ethiopia.; Bahiru B; Department of Social Pharmacy, School of Pharmacy, College of Medicine and Health Science, Bahir Dar University, Bahir Dar, Ethiopia.; Demsie DG; Department of Pharmacology, School of Pharmacy, College of Medicine and Health Science, Bahir Dar University, Bahir Dar, Ethiopia.; Gizachew B; School of Public Health, GAMBY Medical and Business College, Bahir Dar, Ethiopia.; Bizuneh GK; Department of Pharmacognosy, School of Pharmacy, College of Medicine and Health Science, University of Gondar, Gondar, Ethiopia.; Motbaynor G; Department of Medicinal Chemistry, School of Pharmacy, College of Medicine and Health Science, Bahir Dar University, Bahir Dar, Ethiopia.; Yismaw MB; Department of Clinical Pharmacy, School of Pharmacy, College of Medicine and Health Science, Bahir Dar University, Bahir, Ethiopia.; Agmassie Z; Department of Clinical Pharmacy, School of Pharmacy, College of Medicine and Health Science, Bahir Dar University, Bahir, Ethiopia.; Yayehrad AT; Department of Pharmaceutics, School of Pharmacy, College of Medicine and Health Science, Bahir Dar University, Bahir Dar, Ethiopia.; Addisu ZD; Department of Clinical Pharmacy, School of Pharmacy, College of Medicine and Health Science, Bahir Dar University, Bahir, Ethiopia. |
| Source: | Scientific reports [Sci Rep] 2025 Apr 25; Vol. 15 (1), pp. 14417. Date of Electronic Publication: 2025 Apr 25. |
| Publication Type: | Journal Article; Multicenter Study |
| Language: | English |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: London : Nature Publishing Group, copyright 2011- |
| MeSH Terms: | Meningitis, Bacterial*/drug therapy ; Meningitis, Bacterial*/epidemiology ; Anti-Bacterial Agents*/therapeutic use; Ethiopia/epidemiology ; Dexamethasone/therapeutic use ; Humans ; Male ; Female ; Infant ; Child, Preschool ; Treatment Outcome ; Retrospective Studies ; Child ; Comorbidity ; Adolescent |
| Abstract: | Meningitis is a serious health condition with varied treatment outcomes that can be affected due to a difference in demographic factors, clinical conditions, and treatment associated factors. The following study assess the factors to identify predicting factors for affecting the treatment outcomes. The study was done on 423 patients with meningitis retrospectively through chart review on selected hospitals from September 2022 to February 2023. The information obtained from the patient chart including demographic information, clinical state and comorbid conditions were analyzed. Logistic regression was used to identify factors associated with treatment outcomes. The larger proportion of patients (79.2%) were with the age of ≥ 2 months, with males account 52.5% of all study participants. The most common symptoms experienced by the patients were fever (85.8%), irritability (63.1%), and neck rigidity (71.2%). More than half of the participants (57.9%) has a minimum of one comorbid health condition, with pneumonia being the most prevalent comorbid disease (20.6%). In terms of treatment considered, gentamycin (31.9%) and ampicillin (31.1%) were frequently indicated, whereas antibiotic regimen changes were required in 31.9% of meningitis patients. The majority of the patients (75.7%) showed good outcomes with improvement, nevertheless around 24.3% experienced poor outcomes, including death (2.1%) and extended length of stay in hospitals (5.9%). Predicting factors for poor outcomes like delayed access to treatment initiation (Adjusted Odds Ratio (AOR = 4.24, p = 0.001)), existence of comorbidities (AOR = 4.21, p |
| Competing Interests: | Declarations. Competing interests: The authors declare no competing interests. Consent to participants: Not applicable. The study is conducted retrospectively from the chart review and the data obtained kept confidential, no individual details, images, or videos are being used and displayed in this study. |
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| Contributed Indexing: | Keywords: Comorbidities; Dexamethasone; Ethiopia; Meningitis; Pediatric; Treatment outcomes |
| Substance Nomenclature: | 0 (Anti-Bacterial Agents); 7S5I7G3JQL (Dexamethasone) |
| Entry Date(s): | Date Created: 20250425 Date Completed: 20250426 Latest Revision: 20250507 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC12032015 |
| DOI: | 10.1038/s41598-025-91340-1 |
| PMID: | 40280996 |
| Database: | MEDLINE |
Journal Article; Multicenter Study