Preserving Fossilized Soft Tissues: Advancing Proteomics and Unveiling the Evolutionary History of Cancer in Dinosaurs.
| Title: | Preserving Fossilized Soft Tissues: Advancing Proteomics and Unveiling the Evolutionary History of Cancer in Dinosaurs. |
|---|---|
| Authors: | Chandrasinghe PC; Department of Surgery and Cancer, Imperial College London, London W12 0NN, UK.; Department of Surgery, Faculty of Medicine, University of Kelaniya, Kelaniya 11010, Sri Lanka.; Cereser B; Department of Surgery and Cancer, Imperial College London, London W12 0NN, UK.; Bertazzo S; Department of Medical Physics and Biomedical Engineering, University College London, London WC1E 6BT, UK.; Csiki-Sava Z; Faculty of Geology and Geophysics, University of Bucharest, 010041 Bucharest, Romania.; Institute of Geography and Earth Sciences, ELTE Eötvös Loránd University, 1117 Budapest, Hungary.; Stebbing J; Department of Surgery and Cancer, Imperial College London, London W12 0NN, UK.; School of Life Sciences, Anglia Ruskin University, Cambridge CB1 1PT, UK. |
| Source: | Biology [Biology (Basel)] 2025 Apr 03; Vol. 14 (4). Date of Electronic Publication: 2025 Apr 03. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101587988 Publication Model: Electronic Cited Medium: Print ISSN: 2079-7737 (Print) Linking ISSN: 20797737 NLM ISO Abbreviation: Biology (Basel) Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: Basel, Switzerland : MDPI, 2012- |
| Abstract: | Understanding how life-history strategies influence cancer susceptibility in dinosaurs requires a molecular-level analysis of preserved soft tissues. While previous research has largely focused on skeletal remains, the discovery of soft tissue structures in fossils, such as Telmatosaurus transsylvanicus, highlights the need for a new approach. Paleoproteomics offers a transformative opportunity to analyze ancient proteins, revealing the evolutionary trade-offs between growth, reproduction, and cancer suppression. This study argues that prioritizing fossil collection and soft tissue preservation is crucial, as future advances in molecular techniques will allow deeper insights into disease evolution. By integrating life-history theory with paleopathology, we can better understand the selective pressures that shaped cancer susceptibility in extinct species and identify potential mechanisms of tumor resistance. This commentary highlights the necessity of long-term fossil conservation efforts to support future breakthroughs in evolutionary biology and comparative oncology. |
| References: | Science. 2023 Feb 24;379(6634):811-814. (PMID: 36821658); Mol Cancer Res. 2015 Jun;13(6):993-1002. (PMID: 25767210); Nat Commun. 2015 Jun 09;6:7352. (PMID: 26056764); PLoS One. 2011 Apr 29;6(4):e19445. (PMID: 21559386); Animals (Basel). 2024 May 15;14(10):. (PMID: 38791691); Int J Epidemiol. 2016 Jun;45(3):621-37. (PMID: 27582437); Nat Genet. 2014 Jul;46(7):722-5. (PMID: 24859340); Proc Biol Sci. 2012 Dec 7;279(1748):4724-33. (PMID: 23055061); Nat Commun. 2012 May 08;3:824. (PMID: 22569368); Naturwissenschaften. 2003 Nov;90(11):495-500. (PMID: 14610645); Neoplasia. 2010 Dec;12(12):957-68. (PMID: 21170260); BMC Biol. 2017 Jul 13;15(1):60. (PMID: 28705195); Sci Rep. 2016 Jul 05;6:29271. (PMID: 27377317); Nat Rev Genet. 2001 May;2(5):353-9. (PMID: 11331901); Science. 2009 May 1;324(5927):626-31. (PMID: 19407199); PLoS One. 2016 Mar 15;11(3):e0151143. (PMID: 26977600); BMC Ecol Evol. 2022 Dec 13;22(1):143. (PMID: 36513967); Lancet. 1999 Jul 31;354(9176):398. (PMID: 10437878); Elife. 2016 Sep 19;5:. (PMID: 27642012); Science. 2007 Apr 13;316(5822):280-5. (PMID: 17431180); Q Rev Biol. 1976 Mar;51(1):3-47. (PMID: 778893); Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):18496-500. (PMID: 24127577); Nat Rev Cancer. 2013 Dec;13(12):883-92. (PMID: 24213474); Philos Trans R Soc Lond B Biol Sci. 2015 Jul 19;370(1673):. (PMID: 26056363); Nature. 1993 Apr 22;362(6422):709-15. (PMID: 8469282) |
| Grant Information: | P74346 Action Against Cancer |
| Contributed Indexing: | Keywords: evolutionary biology of cancers; fossils; paleopathology; paleoproteomics |
| Entry Date(s): | Date Created: 20250426 Latest Revision: 20250429 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC12025216 |
| DOI: | 10.3390/biology14040370 |
| PMID: | 40282235 |
| Database: | MEDLINE |
Journal Article