Efficacy of Radiotherapy in Patients with Relapsing Primary Rosai-Dorfman Disease of the Nasal Cavity.
| Title: | Efficacy of Radiotherapy in Patients with Relapsing Primary Rosai-Dorfman Disease of the Nasal Cavity. |
|---|---|
| Authors: | Sarafoleanu CC; Department of Otorhinolaryngology, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.; Department of Otorhinolaryngology, 'Sfanta Maria' Clinical Hospital, 011172 Bucharest, Romania.; Badea FC; Department of Otorhinolaryngology, Medicover Hospital, 020331 Bucharest, Romania.; Georgescu AM; Doctoral School, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.; Department of Laboratory Medicine, Victor Babes Clinical Hospital of Infectious Diseases and Pneumophthisiology, 200515 Craiova, Romania.; Musat GC; Department of Otorhinolaryngology, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.; Department of Otorhinolaryngology, 'Sfanta Maria' Clinical Hospital, 011172 Bucharest, Romania.; Andrei A; Department of Radiotherapy, Radiation Therapy Center Amethyst, 075100 Otopeni, Romania.; Tanase I; Department of Otorhinolaryngology, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.; Department of Otorhinolaryngology, 'Sfanta Maria' Clinical Hospital, 011172 Bucharest, Romania. |
| Source: | Medicina (Kaunas, Lithuania) [Medicina (Kaunas)] 2025 Mar 25; Vol. 61 (4). Date of Electronic Publication: 2025 Mar 25. |
| Publication Type: | Case Reports; Journal Article |
| Language: | English |
| Journal Info: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 9425208 Publication Model: Electronic Cited Medium: Internet ISSN: 1648-9144 (Electronic) Linking ISSN: 1010660X NLM ISO Abbreviation: Medicina (Kaunas) Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2018- : Basel, Switzerland : MDPI; Original Publication: Kaunas : Lietuvos gydytojų sąjunga |
| MeSH Terms: | Histiocytosis, Sinus*/radiotherapy ; Nasal Cavity*/physiopathology; Humans ; Female ; Middle Aged ; Recurrence ; Treatment Outcome |
| Abstract: | Rosai-Dorfman disease (RDD) is a rare proliferative disorder characterized by an overproduction of a type of immune cell called histiocytes, with unknown etiology. Although extranodal involvement is not uncommon, it is rarely seen within the nose. The available data are limited, and currently, there are no established guidelines for managing RDD. Different therapeutic options have been described, including corticosteroids, surgery, radiotherapy, or chemotherapy. This study aims to evaluate the potential benefit of radiotherapy in patients with nasal Rosai-Dorfman disease to improve the current diagnostic and therapeutic management. Herein, we report the case of a 54-year-old female patient with nasal RDD refractory to systemic corticosteroid therapy and transnasal endoscopic resection. She received fractionated low-dose radiotherapy with a total dose of 30 cGy administered in 2 cGy daily fractions. Complete remission was achieved, highlighting the potential role of radiotherapy as an effective therapeutic option for relapsing or steroid-refractory cases. This is one of the few well-documented cases reported with nasal Rosai-Dorfman disease treated with radiotherapy. Ongoing research on novel therapies offers hope for improved outcomes in relapsing cases that fail to respond to conventional treatments. |
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| Contributed Indexing: | Keywords: Rosai–Dorfman disease; S100 protein; histiocytosis; radiotherapy; sinonasal |
| Entry Date(s): | Date Created: 20250426 Date Completed: 20250426 Latest Revision: 20250428 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC12028519 |
| DOI: | 10.3390/medicina61040585 |
| PMID: | 40282877 |
| Database: | MEDLINE |
Case Reports; Journal Article