Exploring the Inflammatory Basis of Endometrial Polyps: Clinical Implications of Hematological Biomarkers in a Retrospective Study.
| Title: | Exploring the Inflammatory Basis of Endometrial Polyps: Clinical Implications of Hematological Biomarkers in a Retrospective Study. |
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| Authors: | Keyif B; Department of Obstetrics and Gynecology, Faculty of Medicine, Duzce University, 81620 Duzce, Türkiye.; Yavuzcan A; Department of Obstetrics and Gynecology, University of Health Sciences Ankara City Health Application and Research Centre, 06350 Ankara, Türkiye.; Yurtçu E; Department of Obstetrics and Gynecology, Faculty of Medicine, Duzce University, 81620 Duzce, Türkiye.; Başbuğ A; Department of Obstetrics and Gynecology, Faculty of Medicine, Duzce University, 81620 Duzce, Türkiye.; Düzenli F; Department of Obstetrics and Gynecology, Faculty of Medicine, Duzce University, 81620 Duzce, Türkiye.; Keyif E; Department of Obstetrics and Gynecology, Bolu Izzet Baysal State Hospital, 14300 Bolu, Türkiye.; Goynumer FG; Department of Obstetrics and Gynecology, Faculty of Medicine, Duzce University, 81620 Duzce, Türkiye. |
| Source: | Journal of clinical medicine [J Clin Med] 2025 Apr 17; Vol. 14 (8). Date of Electronic Publication: 2025 Apr 17. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101606588 Publication Model: Electronic Cited Medium: Print ISSN: 2077-0383 (Print) Linking ISSN: 20770383 NLM ISO Abbreviation: J Clin Med Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: Basel, Switzerland : MDPI AG, [2012]- |
| Abstract: | Background/Objectives: Endometrial polyps (EPs) are common benign endometrial lesions often linked to abnormal uterine bleeding and infertility. While hormonal factors play a key role in their development, recent studies suggest a potential inflammatory component. This retrospective study aimed to assess systemic inflammatory markers, including mean platelet volume (MPV), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR), in EP patients. Methods: A total of 180 patients were classified into three groups: EP (n = 60), chronic endometritis (n = 60), and control (n = 60). Preoperative hematological parameters were retrieved from medical records. Group comparisons were performed using one-way ANOVA, with Tukey's post hoc test applied when significant. Multinomial logistic regression was used to identify independent predictors of EPs. Results: MPV and PLR were significantly higher in the EP group compared to other groups (p = 0.014 and p = 0.015, respectively), while NLR differences were not statistically significant (p = 0.086). Logistic regression identified MPV (p = 0.004) and PLR (p = 0.045) as independent predictors of EPs. Conclusions: These findings suggest that systemic inflammation may contribute to EP development, with MPV and PLR serving as potential inflammatory biomarkers. Further prospective studies with histopathological validation are needed to clarify the role of inflammation in EP pathogenesis. |
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| Contributed Indexing: | Keywords: chronic endometritis; endometrial polyp; hematological biomarkers; inflammation; mean platelet volume; neutrophil-to-lymphocyte ratio; platelet-to-lymphocyte ratio |
| Entry Date(s): | Date Created: 20250426 Latest Revision: 20250429 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC12027485 |
| DOI: | 10.3390/jcm14082754 |
| PMID: | 40283584 |
| Database: | MEDLINE |
Journal Article