Geroscience in heart failure: the search for therapeutic targets in the shared pathobiology of human aging and heart failure.
| Title: | Geroscience in heart failure: the search for therapeutic targets in the shared pathobiology of human aging and heart failure. |
|---|---|
| Authors: | Castro C; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA.; Harvard Medical School, Boston, MA 02115, USA.; Delwarde C; Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women's Hospital, Boston, MA 02115, USA.; Harvard Medical School, Boston, MA 02115, USA.; Shi Y; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA.; Roh J; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA.; Harvard Medical School, Boston, MA 02115, USA. |
| Source: | The journal of cardiovascular aging [J Cardiovasc Aging] 2025; Vol. 5 (1). Date of Electronic Publication: 2025 Jan 14. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: OAE Publishing Country of Publication: United States NLM ID: 101778645 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2768-5993 (Electronic) Linking ISSN: 27685993 NLM ISO Abbreviation: J Cardiovasc Aging Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: Alhambra, CA : OAE Publishing, [2021]- |
| Abstract: | Age is a major risk factor for heart failure, but one that has been historically viewed as non-modifiable. Emerging evidence suggests that the biology of aging is malleable, and can potentially be intervened upon to treat age-associated chronic diseases, such as heart failure. While aging biology represents a new frontier for therapeutic target discovery in heart failure, the challenges of translating Geroscience research to the clinic are multifold. In this review, we propose a strategy that prioritizes initial target discovery in human biology. We review the rationale for starting with human omics, which has generated important insights into the shared (patho)biology of human aging and heart failure. We then discuss how this knowledge can be leveraged to identify the mechanisms of aging biology most relevant to heart failure. Lastly, we provide examples of how this human-first Geroscience approach, when paired with rigorous functional assessments in preclinical models, is leading to early-stage clinical development of gerotherapeutic approaches for heart failure. |
| Competing Interests: | Conflicts of interest Roh J receives research support from Keros Therapeutics, Genentech, and Amgen, all of which are unrelated to this work. All other authors declared that there are no conflicts of interest. |
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| Grant Information: | R01 HL170058 United States HL NHLBI NIH HHS |
| Contributed Indexing: | Keywords: Translational research; aging biology; genomics; geroscience; heart failure; proteomics |
| Entry Date(s): | Date Created: 20250429 Latest Revision: 20250501 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC12036312 |
| DOI: | 10.20517/jca.2024.15 |
| PMID: | 40297496 |
| Database: | MEDLINE |
Journal Article