C-reactive protein for pulmonary tuberculosis screening and treatment response monitoring in children.
| Title: | C-reactive protein for pulmonary tuberculosis screening and treatment response monitoring in children. |
|---|---|
| Authors: | Githua J; Mecha J; Stern J; Escudero JN; Njagi L; Kijaro L; Mirera J; Murithi W; John-Stewart G; Maleche-Obimbo E; Nduba V; LaCourse SM |
| Source: | MedRxiv : the preprint server for health sciences [medRxiv] 2025 Apr 25. Date of Electronic Publication: 2025 Apr 25. |
| Publication Type: | Journal Article; Preprint |
| Language: | English |
| Journal Info: | Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE |
| Abstract: | C-reactive protein (CRP) was investigated as a marker for diagnostic screening and monitoring response to treatment for tuberculosis (TB) in Kenyan children. For screening, CRP levels did not differ significantly between children with versus without TB. However, median CRP levels decreased significantly during TB treatment in confirmed (p=0.03) and unconfirmed TB (p=0.002) suggesting potential of treatment response monitoring.; Summary: CRP levels did not differ significantly between children with versus without TB at diagnosis but decreased significantly during TB treatment in confirmed (p=0.02) and unconfirmed TB (p |
| Comments: | Update in: Open Forum Infect Dis. 2026 Jan 07;13(2):ofaf816. doi: 10.1093/ofid/ofaf816.. (PMID: 41660661) |
| Grant Information: | D43 TW011817 United States TW FIC NIH HHS; P30 AI168034 United States AI NIAID NIH HHS |
| Entry Date(s): | Date Created: 20250502 Date Completed: 20260211 Latest Revision: 20260306 |
| Update Code: | 20260306 |
| PubMed Central ID: | PMC12045435 |
| DOI: | 10.1101/2025.04.24.25326338 |
| PMID: | 40313307 |
| Database: | MEDLINE |
Journal Article; Preprint