Partial Heart Transplantation: Early Experience With Pediatric Heart Valve Replacements That Grow.
| Title: | Partial Heart Transplantation: Early Experience With Pediatric Heart Valve Replacements That Grow. |
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| Authors: | Prabhu NK; Duke Congenital Heart Surgery Research and Training Laboratory, Duke University, Durham, NC (N.K.P., B.A., M.M.-M., D.M.O., J.W.T.).; Department of Surgery, Duke University Medical Center, Durham, NC (N.K.P., B.A., D.M.O., J.W.T.).; Aykut B; Duke Congenital Heart Surgery Research and Training Laboratory, Duke University, Durham, NC (N.K.P., B.A., M.M.-M., D.M.O., J.W.T.).; Department of Surgery, Duke University Medical Center, Durham, NC (N.K.P., B.A., D.M.O., J.W.T.).; Mensah-Mamfo M; Duke Congenital Heart Surgery Research and Training Laboratory, Duke University, Durham, NC (N.K.P., B.A., M.M.-M., D.M.O., J.W.T.).; Overbey DM; Duke Congenital Heart Surgery Research and Training Laboratory, Duke University, Durham, NC (N.K.P., B.A., M.M.-M., D.M.O., J.W.T.).; Department of Surgery, Duke University Medical Center, Durham, NC (N.K.P., B.A., D.M.O., J.W.T.).; Turek JW; Duke Congenital Heart Surgery Research and Training Laboratory, Duke University, Durham, NC (N.K.P., B.A., M.M.-M., D.M.O., J.W.T.).; Department of Surgery, Duke University Medical Center, Durham, NC (N.K.P., B.A., D.M.O., J.W.T.). |
| Source: | Circulation [Circulation] 2025 May 20; Vol. 151 (20), pp. 1477-1490. Date of Electronic Publication: 2025 May 19. |
| Publication Type: | Journal Article; Review |
| Language: | English |
| Journal Info: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0147763 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4539 (Electronic) Linking ISSN: 00097322 NLM ISO Abbreviation: Circulation Subsets: MEDLINE |
| Imprint Name(s): | Publication: Hagerstown, MD : Lippincott Williams & Wilkins; Original Publication: [Dallas, Tex., etc., American Heart Association, etc.] |
| MeSH Terms: | Heart Transplantation*/methods ; Heart Transplantation*/trends ; Heart Valves*/growth & development ; Heart Valve Diseases*/surgery ; Heart Valve Prosthesis Implantation*/methods ; Heart Valve Prosthesis*; Humans ; Child |
| Abstract: | Heart valve replacement in children is fraught with long-term morbidity and mortality rates, largely because conventional implants lack the capacity to grow with the child. Partial heart transplantation presents a potential solution by transplanting only specific segments of a donor heart, thereby providing a living and growing heart valve implant. This approach harnesses the full spectrum of cardiac tissues, which, when freshly procured and supported by immunosuppression, can integrate as functional and potentially growth-capable tissue. This state-of-the-art review discusses the history and development of partial heart transplantation, its indications, recent clinical experiences, regulation, and future directions. |
| Competing Interests: | J.W.T. is an equity stakeholder and chief scientific officer of Surge Ingenuity, Inc. The other authors report no conflicts. |
| Contributed Indexing: | Keywords: United States; congenital heart disease; heart transplantation; heart valves; tissue donors |
| Entry Date(s): | Date Created: 20250519 Date Completed: 20250519 Latest Revision: 20250519 |
| Update Code: | 20260130 |
| DOI: | 10.1161/CIRCULATIONAHA.124.072626 |
| PMID: | 40388509 |
| Database: | MEDLINE |
Journal Article; Review