Are Oligodendrocytes the Culprits or Victims in Alzheimer's Disease.
| Title: | Are Oligodendrocytes the Culprits or Victims in Alzheimer's Disease. |
|---|---|
| Authors: | Rapaka D; Veera R Bitra, School of Pharmacy, Faculty of Health Sciences, University of Botswana, Gaborone, Botswana. Email: raghavab27@gmail.com, bitrav@ub.ac.bw.; Saniotis A; Henneberg M; Bitra VR |
| Source: | Physiological research [Physiol Res] 2025 Apr 30; Vol. 74 (2), pp. 219-231. |
| Publication Type: | Journal Article; Review |
| Language: | English |
| Journal Info: | Publisher: Published for the Institute of Physiology of the Czechoslovak Academy of Sciences by Academia, Pub. House of the Academy Country of Publication: Czech Republic NLM ID: 9112413 Publication Model: Print Cited Medium: Internet ISSN: 1802-9973 (Electronic) Linking ISSN: 08628408 NLM ISO Abbreviation: Physiol Res Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Praha : Published for the Institute of Physiology of the Czechoslovak Academy of Sciences by Academia, Pub. House of the Academy |
| MeSH Terms: | Alzheimer Disease*/pathology ; Alzheimer Disease*/metabolism ; Oligodendroglia*/pathology ; Oligodendroglia*/metabolism ; Myelin Sheath*/metabolism ; Myelin Sheath*/pathology; Humans ; Animals |
| Abstract: | Oligodendrocytes are vital for the functioning of the nervous system. Oligodendrocyte-created myelin sheaths work as dynamic partners which play a substantial role in the myelination of axons. In addition to its well-known functions of providing insulation and enhancing conduction velocity, myelination controls axons' maturity, longevity, and regenerative ability via trophic support and signalling molecules. Myelination also regulates ion concentration and offers neuroprotection. Myelin is generated via complex procedures including cell differentiation, specialised lipids, and protein synthesis. Understanding the physiology of myelin sheath formation is required to understand various neurological disorders associated with myelin sheath damage. This review focuses on our growing understanding of the intricate actions and changes in oligodendrocytes during the course of evolution and in Alzheimer's disease. |
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| Entry Date(s): | Date Created: 20250528 Date Completed: 20250528 Latest Revision: 20250611 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC12148139 |
| PMID: | 40432437 |
| Database: | MEDLINE |
Journal Article; Review