Hepatitis C Treatment Initiation During Hospitalization for People Who Use Drugs: A Narrative Review of the Literature.
| Title: | Hepatitis C Treatment Initiation During Hospitalization for People Who Use Drugs: A Narrative Review of the Literature. |
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| Authors: | Denkins J; Department of Pharmacy, Oregon Health & Science University, Portland, Oregon, USA.; Babiarz J; Division of Internal Medicine and Geriatrics, Department of Medicine, Oregon Health & Science University, Portland, Oregon, USA.; Ham Y; Department of Pharmacy, Oregon Health & Science University, Portland, Oregon, USA.; Ryu H; Department of Pharmacy, Oregon Health & Science University, Portland, Oregon, USA.; Ricci B; Division of Internal Medicine and Geriatrics, Department of Medicine, Oregon Health & Science University, Portland, Oregon, USA.; Williams C; Division of General Internal Medicine and Geriatrics, Department of Care Management, Oregon Health & Science University, Portland, Oregon, USA.; Alexander I; Division of General Internal Medicine and Geriatrics, Department of Care Management, Oregon Health & Science University, Portland, Oregon, USA.; Tucker K; Department of Pharmacy Practice, College of Pharmacy, Oregon State University, Portland, Oregon, USA.; McCrary LM; Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA.; Levander X; Section of Addiction Medicine, Division of General Internal Medicine and Geriatrics, Department of Medicine, Oregon Health & Science University, Portland, Oregon, USA. |
| Source: | Open forum infectious diseases [Open Forum Infect Dis] 2025 Apr 24; Vol. 12 (6), pp. ofaf237. Date of Electronic Publication: 2025 Apr 24 (Print Publication: 2025). |
| Publication Type: | Journal Article; Review |
| Language: | English |
| Journal Info: | Publisher: Published by Oxford University Press on behalf of the Infectious Diseases Society of America Country of Publication: United States NLM ID: 101637045 Publication Model: eCollection Cited Medium: Print ISSN: 2328-8957 (Print) Linking ISSN: 23288957 NLM ISO Abbreviation: Open Forum Infect Dis Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: Cary, NC : Published by Oxford University Press on behalf of the Infectious Diseases Society of America, [2014]- |
| Abstract: | People who use drugs (PWUD) are increasingly acquiring and transmitting hepatitis C virus (HCV) and being admitted to the hospital for often costly non-HCV-related conditions. Traditionally, treatment of HCV has been deferred to the outpatient setting. However, outpatient HCV follow-up can be an arduous process to navigate with resultant gaps in care, especially for PWUD with numerous complex psychosocial and medical comorbidities. Hospitalization presents a key opportunity to initiate treatment, and several institutions have piloted inpatient treatment models with intensive outreach. We conducted a narrative review of peer-reviewed literature (2014-2024) evaluating hospital-based HCV treatment models for PWUD; 6 studies from 4 countries met inclusion criteria. Evidence suggests that engaging PWUD during hospitalization leads to higher treatment initiation and completion as compared with standard-of-care outpatient referral. Inpatient HCV treatment models should be one part of a comprehensive plan in the United States and internationally to eliminate HCV for all.; (© The Author(s) 2025. Published by Oxford University Press on behalf of Infectious Diseases Society of America.) |
| Competing Interests: | Potential conflicts of interest. All authors: No reported conflicts. |
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| Grant Information: | K12 DA061526 United States DA NIDA NIH HHS |
| Contributed Indexing: | Keywords: hepatitis C virus; hospitalization; people who use drugs; transitional care; vulnerable populations |
| Entry Date(s): | Date Created: 20250602 Latest Revision: 20260402 |
| Update Code: | 20260402 |
| PubMed Central ID: | PMC12125678 |
| DOI: | 10.1093/ofid/ofaf237 |
| PMID: | 40453882 |
| Database: | MEDLINE |
Journal Article; Review