Loranthus tienyenensis Li and Planchonella obovata (R. Br.) Pierre: Essential Oil Composition, Biological Activity, and Molecular Docking.
| Title: | Loranthus tienyenensis Li and Planchonella obovata (R. Br.) Pierre: Essential Oil Composition, Biological Activity, and Molecular Docking. |
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| Authors: | Pham TV; Faculty of Chemistry, University of Education, Hue University, Hue, Vietnam.; Hoang TX; Faculty of Biology, University of Education, Hue University, Hue, Vietnam.; Luyen ND; Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam.; Quan PM; Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam.; Hung NH; Department of Pharmacy, Duy Tan University, Danang, Vietnam.; Center for Advanced Chemistry, Institute of Research and Development, Duy Tan University, Danang, Vietnam.; Hao NT; Faculty of Biotechnology, Vietnam National University of Agriculture, Hanoi, Vietnam.; Gioi DH; Faculty of Biotechnology, Vietnam National University of Agriculture, Hanoi, Vietnam.; Linh NN; Faculty of Pharmacy, Thanh Do University, Hanoi, Vietnam.; Duy DA; The Village School, A Nord Anglia Education School, Houston, Texas, USA.; Son NT; Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam. |
| Source: | Chemistry & biodiversity [Chem Biodivers] 2025 Nov; Vol. 22 (11), pp. e01009. Date of Electronic Publication: 2025 Jul 10. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Verlag Helvetica Chimica Acta Country of Publication: Switzerland NLM ID: 101197449 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1612-1880 (Electronic) Linking ISSN: 16121872 NLM ISO Abbreviation: Chem Biodivers Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Zürich, Switzerland : Hoboken, NJ : Verlag Helvetica Chimica Acta ; Distributed in the USA by Wiley, c2004- |
| MeSH Terms: | Oils, Volatile*/chemistry ; Oils, Volatile*/pharmacology ; Oils, Volatile*/isolation & purification ; Anti-Bacterial Agents*/pharmacology ; Anti-Bacterial Agents*/chemistry ; Anti-Bacterial Agents*/isolation & purification ; Loranthaceae*/chemistry ; Loranthaceae*/metabolism ; Antifungal Agents*/pharmacology ; Antifungal Agents*/chemistry ; Antifungal Agents*/isolation & purification ; Insecticides*/pharmacology ; Insecticides*/chemistry ; Insecticides*/isolation & purification ; Molecular Docking Simulation*; Candida albicans/drug effects ; Plant Leaves/chemistry ; Plant Leaves/metabolism ; Pseudomonas aeruginosa/drug effects ; Escherichia coli/drug effects ; Aedes/drug effects ; Gram-Negative Bacteria/drug effects ; Larva/drug effects ; Microbial Sensitivity Tests ; Animals ; Structure-Activity Relationship ; Gas Chromatography-Mass Spectrometry ; Dose-Response Relationship, Drug ; Molecular Structure |
| Abstract: | This study presents the first phytochemical analysis of the essential oils from the fresh leaves of Loranthus tienyenensis Li and Planchonella obovata (R. Br.) Pierre using gas chromatography-mass spectrometry. L. tienyenensis essential oil was characterized by neryl isobutanoate (13.8%), linalool (10.8%), cis-linalool oxide (6.5%), hexadecanoic acid (6.2%), trans-linalool oxide (5.6%), and cis-phytol (5.5%). P. obovata essential oil was dominated by (Z,E)-α-farnesene (13.7%) and (3Z)-cembrene A (12.0%). P. obovata essential oil exhibited strong antimicrobial activity against Gram-negative bacteria Escherichia coli and Pseudomonas aeruginosa, and the yeast Candida albicans, with the same minimum inhibitory concentration of 32 µg/mL. Both essential oils showed moderate larvicidal activity against third-instar larvae of Aedes aegypti, Ae. albopictus, and Culex quinquefasciatus, with 24-h lethal dose 50% values below 100 µg/mL. Molecular docking revealed that (Z,E)-α-farnesene interacted with bacterial proteins enoyl-ACP reductase (FabI), dihydrofolate reductase (DHFR), and beta-lactamase, while (3Z)-cembrene A effectively targeted DHFR, DNA gyrase, and peptidoglycan transpeptidase.; (© 2025 Wiley‐VHCA AG, Zurich, Switzerland.) |
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| Contributed Indexing: | Keywords: Loranthus tienyenensis; Planchonella obovata; biological activity; essential oil; molecular docking |
| Substance Nomenclature: | 0 (Oils, Volatile); 0 (Anti-Bacterial Agents); 0 (Antifungal Agents); 0 (Insecticides) |
| Entry Date(s): | Date Created: 20250710 Date Completed: 20251119 Latest Revision: 20251216 |
| Update Code: | 20260130 |
| DOI: | 10.1002/cbdv.202501009 |
| PMID: | 40638914 |
| Database: | MEDLINE |
Journal Article