Single-Pass Albumin Dialysis (SPAD) as a Therapeutic Extracorporeal Liver Support in a Low-Resource Setting: Case Report and Literature Review.
| Title: | Single-Pass Albumin Dialysis (SPAD) as a Therapeutic Extracorporeal Liver Support in a Low-Resource Setting: Case Report and Literature Review. |
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| Authors: | Roman Hernández D; Intensive Care Unit, Hospital General 'Dr. Manuel Gea Gonzalez', Mexico City, MEX.; Valdez-Gaona A; Intensive Care Unit, Hospital General 'Dr. Manuel Gea Gonzalez', Mexico City, MEX.; García-Velasco LA; Intensive Care Unit, Hospital General 'Dr. Manuel Gea Gonzalez', Mexico City, MEX.; Lemus JS; Intensive Care Unit, Hospital General 'Dr. Manuel Gea Gonzalez', Mexico City, MEX.; González Herrera O; Intensive Care Unit, Hospital General 'Dr. Manuel Gea González', Mexico City, MEX.; Cardenas Membrila G; Intensive Care Unit, Hospital General 'Dr. Manuel Gea Gonzalez', Mexico City, MEX. |
| Source: | Cureus [Cureus] 2025 Jun 11; Vol. 17 (6), pp. e85782. Date of Electronic Publication: 2025 Jun 11 (Print Publication: 2025). |
| Publication Type: | Case Reports; Journal Article |
| Language: | English |
| Journal Info: | Publisher: Cureus, Inc Country of Publication: United States NLM ID: 101596737 Publication Model: eCollection Cited Medium: Print ISSN: 2168-8184 (Print) Linking ISSN: 21688184 NLM ISO Abbreviation: Cureus Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: Palo Alto, CA : Cureus, Inc. |
| Abstract: | Acute liver failure, a condition marked by high mortality, leads to a loss of liver function that impairs the detoxification of substances such as bilirubin, ammonia, and lactate, as well as the liver's synthetic functions, causing damage to other organs. New extracorporeal therapies, including single-pass albumin dialysis (SPAD), have been developed to support liver function. We present a case of a 25-year-old male with no significant past medical history who presented with multiple organ failure and acute kidney injury that required continuous renal replacement therapy (CRRT) with continuous venovenous hemodiafiltration (CVVHDF), necessitating SPAD for the treatment of the liver failure.; (Copyright © 2025, Roman Hernández et al.) |
| Competing Interests: | Human subjects: Consent for treatment and open access publication was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. |
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| Contributed Indexing: | Keywords: acute kidney injury (aki); acute liver failure (alf); acute-on-chronic liver failure (aclf); continuous venovenous hemodiafiltration (cvvhdf); intermittent hemodialysis (ihd); molecular adsorbent recirculating system (mars); single-pass albumin dialysis (spad) |
| Entry Date(s): | Date Created: 20250714 Latest Revision: 20250716 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC12249485 |
| DOI: | 10.7759/cureus.85782 |
| PMID: | 40656314 |
| Database: | MEDLINE |
Case Reports; Journal Article