Nano-enhanced Fenton/Fenton-like chemistry: integrating peroxidase nanozymes, MOFs, and MXenes for next-generation colorimetric biosensors.
| Title: | Nano-enhanced Fenton/Fenton-like chemistry: integrating peroxidase nanozymes, MOFs, and MXenes for next-generation colorimetric biosensors. |
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| Authors: | Nguyen HA; Department of Molecular Biology, Institute of Food and Biotechnology, Can Tho University Can Tho City Vietnam.; Phuong NTT; Nguyen Tat Thanh University Center for Hi-Tech Development Saigon Hi-Tech Park Ho Chi Minh City Vietnam.; NTT Hi-Tech Institute, Nguyen Tat Thanh University Ho Chi Minh City Vietnam.; Tran NB; Faculty of Materials Science and Technology, University of Science Ho Chi Minh City 70000 Vietnam ttnhoa@hcmus.edu.vn.; Vietnam National University Ho Chi Minh City 70000 Vietnam.; Trinh TND; BioTechnology Institute, Tra Vinh University Tra Vinh City 87000 Vietnam.; Mai NXD; Vietnam National University Ho Chi Minh City 70000 Vietnam.; Center for Innovative Materials and Architectures Ho Chi Minh City 70000 Vietnam tktloan@inomar.edu.vn.; Tran NQ; Vietnam National University Ho Chi Minh City 70000 Vietnam.; Center for Innovative Materials and Architectures Ho Chi Minh City 70000 Vietnam tktloan@inomar.edu.vn.; Tran NHT; Faculty of Materials Science and Technology, University of Science Ho Chi Minh City 70000 Vietnam ttnhoa@hcmus.edu.vn.; Vietnam National University Ho Chi Minh City 70000 Vietnam.; Trinh KTL; Vietnam National University Ho Chi Minh City 70000 Vietnam.; Center for Innovative Materials and Architectures Ho Chi Minh City 70000 Vietnam tktloan@inomar.edu.vn. |
| Source: | Nanoscale advances [Nanoscale Adv] 2025 Jun 30; Vol. 7 (16), pp. 4763-4779. Date of Electronic Publication: 2025 Jun 30 (Print Publication: 2025). |
| Publication Type: | Journal Article; Review |
| Language: | English |
| Journal Info: | Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101738708 Publication Model: eCollection Cited Medium: Internet ISSN: 2516-0230 (Electronic) Linking ISSN: 25160230 NLM ISO Abbreviation: Nanoscale Adv Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: Cambridge : Royal Society of Chemistry, [2019]- |
| Abstract: | Colorimetric biosensors exhibit promising potential toward molecular analysis with a wide range of sample types such as clinical, environmental, animal, and plant samples due to their high portability, sensitivity, specificity, and accuracy. Colorimetric biosensors rely on chromogenic reactions to transduce biochemical signals into visible color changes. Among the various signal transduction mechanisms, the Fenton/Fenton-like reaction is an outstanding reaction that can be used to detect a broad spectrum of analytes under diverse conditions. The ability to detect a wide range of analytes expands the application of the Fenton/Fenton-like reaction; this comes at the cost of specificity. This review highlights how integrating nanomaterials, such as peroxidase nanozymes, metal-organic frameworks (MOFs), and MXenes, can improve conventional Fenton/Fenton-like reactions, significantly enhancing specificity, selectivity, and catalytic efficiency. Besides, we demonstrated that the terms "Fenton/Fenton-like reaction" and "peroxidase-mimic nanozyme activity" fundamentally describe the same catalytic process, providing a unified perspective for researchers in the field. Moreover, the incorporation of MOFs and MXenes offers abundant active sites and enhanced electron transfer, resulting in improved sensitivity and selectivity in Fenton-based colorimetric assays.; (This journal is © The Royal Society of Chemistry.) |
| Competing Interests: | There are no conflicts to declare. |
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| Entry Date(s): | Date Created: 20250716 Latest Revision: 20250807 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC12257359 |
| DOI: | 10.1039/d5na00387c |
| PMID: | 40666603 |
| Database: | MEDLINE |
Journal Article; Review