On-Table Reanimation of a Pediatric Heart from Donation after Circulatory Death.
| Title: | On-Table Reanimation of a Pediatric Heart from Donation after Circulatory Death. |
|---|---|
| Authors: | Kucera JA; Congenital Heart Surgery Research and Training Laboratory, Duke University, Durham, NC.; Overbey DM; Congenital Heart Surgery Research and Training Laboratory, Duke University, Durham, NC.; Duke Children's Pediatric and Congenital Heart Center, Duke University, Durham, NC.; Duke Department of Surgery, Duke University, Durham, NC.; Turek JW; Congenital Heart Surgery Research and Training Laboratory, Duke University, Durham, NC.; Duke Children's Pediatric and Congenital Heart Center, Duke University, Durham, NC.; Duke Department of Surgery, Duke University, Durham, NC. |
| Source: | The New England journal of medicine [N Engl J Med] 2025 Jul 17; Vol. 393 (3), pp. 275-280. |
| Publication Type: | Journal Article; Case Reports |
| Language: | English |
| Journal Info: | Publisher: Massachusetts Medical Society Country of Publication: United States NLM ID: 0255562 Publication Model: Print Cited Medium: Internet ISSN: 1533-4406 (Electronic) Linking ISSN: 00284793 NLM ISO Abbreviation: N Engl J Med Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Boston, Massachusetts Medical Society. |
| MeSH Terms: | Allografts*/physiopathology ; Allografts*/supply & distribution ; Heart*/physiopathology ; Heart Transplantation*/adverse effects ; Heart Transplantation*/instrumentation ; Heart Transplantation*/methods ; Perfusion*/adverse effects ; Perfusion*/instrumentation ; Perfusion*/methods ; Tissue and Organ Harvesting*/methods; Heart Failure/surgery ; Transplantation, Homologous/methods ; Animals ; Female ; Humans ; Infant ; Death ; Models, Animal ; Swine ; Tissue Donors ; Treatment Outcome |
| Abstract: | Cardiac allotransplantation is warranted in children with end-stage heart failure or irreparable congenital heart disease. A dearth of organs for transplantation has contributed to long wait-list times and resultant deaths in this population. Donation after circulatory death (DCD) with normothermic regional perfusion has the potential to increase the donor pool by up to 30%. Ethical concerns have limited adoption of this technique in the United States and abroad. Consequently, a method facilitating ex vivo resuscitation of hearts from deceased donors after circulatory death (i.e., DCD hearts) is needed. We describe an on-table reanimation of a pediatric DCD heart transplanted into a 3-month-old recipient. Adverse events are reported.; (Copyright © 2025 Massachusetts Medical Society.) |
| Comments: | Comment in: N Engl J Med. 2025 Oct 30;393(17):1756-1757. doi: 10.1056/NEJMc2511568.. (PMID: 41160835); Comment in: N Engl J Med. 2025 Oct 30;393(17):1757. doi: 10.1056/NEJMc2511568.. (PMID: 41160836); Comment in: N Engl J Med. 2025 Oct 30;393(17):1757-1758. doi: 10.1056/NEJMc2511568.. (PMID: 41160837); Comment in: N Engl J Med. 2025 Oct 30;393(17):1758. doi: 10.1056/NEJMc2511568.. (PMID: 41160838); Comment in: N Engl J Med. 2025 Oct 30;393(17):1758-1759. doi: 10.1056/NEJMc2511568.. (PMID: 41160839); Comment in: N Engl J Med. 2025 Oct 30;393(17):1759. doi: 10.1056/NEJMc2511568.. (PMID: 41160840); Comment in: N Engl J Med. 2025 Oct 30;393(17):1760. doi: 10.1056/NEJMc2511568.. (PMID: 41160841) |
| Entry Date(s): | Date Created: 20250717 Date Completed: 20250717 Latest Revision: 20251029 |
| Update Code: | 20260130 |
| DOI: | 10.1056/NEJMoa2503487 |
| PMID: | 40673586 |
| Database: | MEDLINE |
Journal Article; Case Reports