Parvalbumin expression identifies subicular principal cells with high projection specificity.
| Title: | Parvalbumin expression identifies subicular principal cells with high projection specificity. |
|---|---|
| Authors: | Baccini G; Institute of Physiology, Christian-Albrechts-University Kiel, Kiel, Germany. Electronic address: g.baccini@physiologie.uni-kiel.de.; Foggetti A; Institute of Physiology, Christian-Albrechts-University Kiel, Kiel, Germany; Department of Neurology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Haining, China.; Wernet N; Institute of Physiology II, Faculty of Medicine, Albert-Ludwigs-University Freiburg, Freiburg, Germany.; Engelhardt KA; MSH Medical School Hamburg, IMM Institute for Molecular Medicine, Medical University, Hamburg, Germany.; Steinecke CS; Institute of Physiology, Christian-Albrechts-University Kiel, Kiel, Germany.; Edelmann E; Institute of Physiology, Christian-Albrechts-University Kiel, Kiel, Germany.; Balueva K; Institute of Physiology, Christian-Albrechts-University Kiel, Kiel, Germany.; Kronenbitter K; Institute of Physiology, Christian-Albrechts-University Kiel, Kiel, Germany.; Michels J; Zoological Institute, Christian-Albrechts-University Kiel, Kiel, Germany.; Kulik A; Institute of Physiology II, Faculty of Medicine, Albert-Ludwigs-University Freiburg, Freiburg, Germany.; Wozny C; MSH Medical School Hamburg, IMM Institute for Molecular Medicine, Medical University, Hamburg, Germany.; Wulff P; Institute of Physiology, Christian-Albrechts-University Kiel, Kiel, Germany. Electronic address: p.wulff@physiologie.uni-kiel.de. |
| Source: | Cell reports [Cell Rep] 2025 Aug 26; Vol. 44 (8), pp. 116004. Date of Electronic Publication: 2025 Jul 16. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: [Cambridge, MA] : Cell Press, c 2012- |
| MeSH Terms: | Parvalbumins*/metabolism ; Hippocampus*/metabolism ; Hippocampus*/cytology ; Neurons*/metabolism; Interneurons/metabolism ; Pyramidal Cells/metabolism ; Animals ; Mice |
| Abstract: | The calcium-binding protein parvalbumin is an established marker for a subset of cortical inhibitory interneurons with similar biophysical features and connectivity. However, parvalbumin is also expressed in a population of excitatory layer 5 cells in neocortex with specific sub-cortical projection targets. Parvalbumin may thus also in excitatory cells identify subclasses with distinct connectivity and function. Here, we investigate parvalbumin expression in excitatory neurons of the hippocampal formation and whether it delineates neurons with specific features. We report parvalbumin-expressing glutamatergic cells in the dorsal distal subiculum, which separate into two subclasses: neurons in deep layers, which specifically project to the antero-ventral thalamus, and neurons in superficial layers, which project to the mammillary bodies. Contrary to adjacent pyramidal cells parvalbumin-positive neurons are non-bursting and display typical morphology. Functionally, the projections diverge from classical driver/modulator subdivisions. Parvalbumin thus marks two sub-types of subicular projection neurons with high target specificity and unique functional features.; (Copyright © 2025 The Authors. Published by Elsevier Inc. All rights reserved.) |
| Competing Interests: | Declaration of interests The authors declare no competing interests. |
| Contributed Indexing: | Keywords: CP: Cell biology; CP: Neuroscience; GABA; antero-ventral thalamus; co-expression; glutamate; mammillary body; oblique dendrite; parvalbumin; regular firing; subiculum; synaptic depression |
| Substance Nomenclature: | 0 (Parvalbumins) |
| Entry Date(s): | Date Created: 20250717 Date Completed: 20250829 Latest Revision: 20250830 |
| Update Code: | 20260130 |
| DOI: | 10.1016/j.celrep.2025.116004 |
| PMID: | 40674213 |
| Database: | MEDLINE |
Journal Article