The role of blood-based biomarkers in Parkinsonian disorders, Alzheimer's disease and frontotemporal dementia.
| Title: | The role of blood-based biomarkers in Parkinsonian disorders, Alzheimer's disease and frontotemporal dementia. |
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| Authors: | Campagnolo M; Neurodegenerative Disease Unit, Centre for Rare Neurological Diseases (ERN-RND), Department of Neuroscience, Padua Neuroscience Center (PNC), University of Padua, Via Giustiniani, 5 - 35128 Padua, Italy. Electronic address: marta.campagnolo@unipd.it.; Fiorenzato E; Neurodegenerative Disease Unit, Centre for Rare Neurological Diseases (ERN-RND), Department of Neuroscience, Padua Neuroscience Center (PNC), University of Padua, Via Giustiniani, 5 - 35128 Padua, Italy. Electronic address: eleonora.fiorenzato@unipd.it.; Musso G; Department of Medicine - DIMED, University of Padua, Via Giustiniani, 2 - 35128 Padua, Italy; Laboratory Medicine, University-Hospital of Padua, via Giustiniani, 2 - 35128, Padua, Italy. Electronic address: giulia.musso@unipd.it.; Misenti V; Neurodegenerative Disease Unit, Centre for Rare Neurological Diseases (ERN-RND), Department of Neuroscience, Padua Neuroscience Center (PNC), University of Padua, Via Giustiniani, 5 - 35128 Padua, Italy. Electronic address: valentina.misenti@unipd.it.; Cauzzo S; Neurodegenerative Disease Unit, Centre for Rare Neurological Diseases (ERN-RND), Department of Neuroscience, Padua Neuroscience Center (PNC), University of Padua, Via Giustiniani, 5 - 35128 Padua, Italy. Electronic address: simone.cauzzo@unipd.it.; Cagnin A; Department of Neuroscience, University of Padua, Via Giustiniani, 5 - 35128 Padua, Italy; Padova Neuroscience Center (PNC), University of Padua, Via Giuseppe Orus, 2/b - 35131 Padua, Italy. Electronic address: annachiara.cagnin@unipd.it.; Biundo R; Department of General Psychology, University of Padua, Via Venezia, 8 - 35131 Padua, Italy; IRCCS, San Camillo Hospital, Via Alberoni, 70 - 30126, Venice, Lido, Italy. Electronic address: roberta.biundo@unipd.it.; Bussè C; Department of Neuroscience, University of Padua, Via Giustiniani, 5 - 35128 Padua, Italy; Padova Neuroscience Center (PNC), University of Padua, Via Giuseppe Orus, 2/b - 35131 Padua, Italy. Electronic address: cinzia.busse@unipd.it.; Fogliano CA; Neurodegenerative Disease Unit, Centre for Rare Neurological Diseases (ERN-RND), Department of Neuroscience, Padua Neuroscience Center (PNC), University of Padua, Via Giustiniani, 5 - 35128 Padua, Italy. Electronic address: carmelo.fogliano1@gmail.com.; Mozzetta S; Department of Neuroscience, University of Padua, Via Giustiniani, 5 - 35128 Padua, Italy; Padova Neuroscience Center (PNC), University of Padua, Via Giuseppe Orus, 2/b - 35131 Padua, Italy. Electronic address: stefano.mozzetta@aopd.veneto.it.; Codemo A; Regional Brain Aging Center, University Hospital of Padua, Piazza de Claricini, 12 - 35030 Selvazzano Dentro, Padua, Italy. Electronic address: alessandra.codemo@aopd.veneto.it.; Gasparoli E; Regional Brain Aging Center, University Hospital of Padua, Piazza de Claricini, 12 - 35030 Selvazzano Dentro, Padua, Italy. Electronic address: elisabetta.gasparoli@aopd.veneto.it.; Moz S; Laboratory Medicine, University-Hospital of Padua, via Giustiniani, 2 - 35128, Padua, Italy. Electronic address: stefania.moz@aopd.veneto.it.; Narici M; Department of Biomedical Sciences, University of Padua, Via Ugo Bassi, 58/b - 35131 Padua, Italy. Electronic address: marco.narici@unipd.it.; Pizzo P; Department of Biomedical Sciences, University of Padua, Via Ugo Bassi, 58/b - 35131 Padua, Italy; Institute of Neuroscience, National Research Council (CNR), University of Padua, Via Ugo Bassi, 58/b - 35131 Padua, Italy. Electronic address: paola.pizzo@unipd.it.; Corbetta M; Department of Neuroscience, University of Padua, Via Giustiniani, 5 - 35128 Padua, Italy; Padova Neuroscience Center (PNC), University of Padua, Via Giuseppe Orus, 2/b - 35131 Padua, Italy. Electronic address: maurizio.corbetta@unipd.it.; Montagnana M; Department of Medicine - DIMED, University of Padua, Via Giustiniani, 2 - 35128 Padua, Italy; Laboratory Medicine, University-Hospital of Padua, via Giustiniani, 2 - 35128, Padua, Italy. Electronic address: martina.montagnana@unipd.it.; Antonini A; Neurodegenerative Disease Unit, Centre for Rare Neurological Diseases (ERN-RND), Department of Neuroscience, Padua Neuroscience Center (PNC), University of Padua, Via Giustiniani, 5 - 35128 Padua, Italy; IRCCS, San Camillo Hospital, Via Alberoni, 70 - 30126, Venice, Lido, Italy. Electronic address: angelo.antonini@unipd.it. |
| Source: | Journal of the neurological sciences [J Neurol Sci] 2025 Sep 15; Vol. 476, pp. 123617. Date of Electronic Publication: 2025 Jul 11. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0375403 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5883 (Electronic) Linking ISSN: 0022510X NLM ISO Abbreviation: J Neurol Sci Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Amsterdam : Elsevier, |
| MeSH Terms: | Alzheimer Disease*/blood ; Alzheimer Disease*/diagnosis ; Frontotemporal Dementia*/blood ; Frontotemporal Dementia*/diagnosis ; Neurofilament Proteins*/blood ; Parkinsonian Disorders*/blood ; Parkinsonian Disorders*/diagnosis ; Parkinson Disease*/blood ; Parkinson Disease*/diagnosis; Biomarkers/blood ; tau Proteins/blood ; Glial Fibrillary Acidic Protein/blood ; Supranuclear Palsy, Progressive/blood ; Supranuclear Palsy, Progressive/diagnosis ; Multiple System Atrophy/blood ; Multiple System Atrophy/diagnosis ; Humans ; Male ; Female ; Aged ; Middle Aged ; Cohort Studies ; Aged, 80 and over |
| Abstract: | The complexity of neurodegenerative disorders necessitates an integrative approach that incorporates morphological, functional, and molecular biomarkers. The advent of highly sensitive single-molecule array (Simoa®) assays has significantly enhanced the accuracy of blood-based biomarker quantification, including glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), and phosphorylated tau181 (p-tau181). This study evaluates the diagnostic utility of these biomarkers in neurodegenerative diseases. We analyzed data from 279 individuals from the PADUA-CESNE cohort: 120 with Parkinson's disease (PD), 88 with Alzheimer's disease (AD), 16 with frontotemporal dementia (FTD), 11 with multiple system atrophy (MSA), 14 with progressive supranuclear palsy (PSP), and 30 cognitively unimpaired controls. NfL levels were significantly lower in PD and AD compared to atypical parkinsonisms and FTD, effectively distinguishing MSA and PSP from controls. NfL also negatively correlated with Montreal Cognitive Assessment (MoCA) scores in AD and PD, indicating its association with cognitive decline. Elevated GFAP levels were observed in both PD and AD and inversely correlated with global cognition. Combining GFAP and p-tau181 improved AD differentiation from PD and other parkinsonian disorders, while the integration of all three biomarkers facilitated the distinction between AD and FTD. Notably, lower NfL levels ( |
| Contributed Indexing: | Keywords: Blood-based biomarkers; Glial fibrillary acidic protein (GFAP); Neurodegenerative diseases; Neurofilament light chain (NfL); Parkinson's disease; Phosphorylated tau181 (p-tau181) |
| Substance Nomenclature: | 0 (Biomarkers); 0 (Neurofilament Proteins); 0 (tau Proteins); 0 (neurofilament protein L); 0 (Glial Fibrillary Acidic Protein); 0 (GFAP protein, human) |
| Entry Date(s): | Date Created: 20250719 Date Completed: 20250828 Latest Revision: 20260506 |
| Update Code: | 20260507 |
| DOI: | 10.1016/j.jns.2025.123617 |
| PMID: | 40682931 |
| Database: | MEDLINE |
Journal Article