The podocyte gets a pedicure: tiny nail clippers for podocyte foot processes.
| Title: | The podocyte gets a pedicure: tiny nail clippers for podocyte foot processes. |
|---|---|
| Authors: | Al-Rabadi LF; Division of Nephrology, Department of Medicine, University of Utah, Salt Lake City, Utah, USA.; Beck LH Jr; Section of Nephrology, Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA; Boston Medical Center, Boston, Massachusetts, USA. Electronic address: Laurence.Beck@bmc.org. |
| Source: | Kidney international [Kidney Int] 2025 Aug; Vol. 108 (2), pp. 176-178. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Elsevier Country of Publication: United States NLM ID: 0323470 Publication Model: Print Cited Medium: Internet ISSN: 1523-1755 (Electronic) Linking ISSN: 00852538 NLM ISO Abbreviation: Kidney Int Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2016- : New York : Elsevier; Original Publication: New York, Springer-Verlag. |
| MeSH Terms: | Podocytes*/metabolism ; Glomerulonephritis, Membranous*/pathology ; Glomerulonephritis, Membranous*/metabolism; Receptors, Phospholipase A2/metabolism ; Dystroglycans/metabolism ; Membrane Proteins/metabolism ; Humans ; Animals ; Thrombospondins |
| Abstract: | Proteases, such as A disintegrin and metalloproteinase 10, can cleave the extracellular domains of transmembrane proteins and trigger a subsequent regulated intramembrane proteolysis step that releases the cytosolic domain into the cell. In this issue, Rosenbaum et al. unraveled the role of A disintegrin and metalloproteinase 10 in the podocyte by showing that it can release the ectodomains of the membranous nephropathy target antigens phospholipase A2 receptor 1 and thrombospondin type 1 domain-containing 7A as well as the adhesion molecule β-dystroglycan.; (Copyright © 2025 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.) |
| Substance Nomenclature: | 0 (Receptors, Phospholipase A2); 146888-27-9 (Dystroglycans); 0 (Membrane Proteins); 0 (THSD7A protein, human); 0 (PLA2R1 protein, human); 0 (Thrombospondins) |
| Entry Date(s): | Date Created: 20250720 Date Completed: 20250720 Latest Revision: 20260127 |
| Update Code: | 20260130 |
| DOI: | 10.1016/j.kint.2025.05.009 |
| PMID: | 40685177 |
| Database: | MEDLINE |
Journal Article