Swine model of Bundibugyo and Reston virus infection reveals a robust immune response following the infection: A multi-tissue immune profiling study.
| Title: | Swine model of Bundibugyo and Reston virus infection reveals a robust immune response following the infection: A multi-tissue immune profiling study. |
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| Authors: | Kim JV; National Centre for Foreign Animal Diseases, Canadian Food Inspection Agency, Winnipeg, MB, Canada.; Lewis CE; Department of Veterinary Microbiology and Preventive Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA, United States; Interdepartmental Microbiology Program, College of Agriculture and Life Sciences, Iowa State University, Ames, IA, United States.; Pinette M; Public Health Agency of Canada, Winnipeg, MB, Canada.; Dawson HD; Diet, Genomics, and Immunology Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service, United States; Department of Agriculture, Rm. 228, Bldg. 307C, BARC-East, 10, 300 Baltimore Ave., Beltsville, MD, United States.; Lung O; National Centre for Foreign Animal Diseases, Canadian Food Inspection Agency, Winnipeg, MB, Canada; Department of Biological Sciences, University of Manitoba, Winnipeg, MB, Canada.; McGill J; Department of Veterinary Microbiology and Preventive Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA, United States.; Pickering BS; National Centre for Foreign Animal Diseases, Canadian Food Inspection Agency, Winnipeg, MB, Canada; Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MB, Canada. Electronic address: bradley.pickering@inspection.gc.ca. |
| Source: | Advances in virus research [Adv Virus Res] 2025; Vol. 122, pp. 79-97. Date of Electronic Publication: 2025 Apr 04. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Academic Press Country of Publication: United States NLM ID: 0370441 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-8399 (Electronic) Linking ISSN: 00653527 NLM ISO Abbreviation: Adv Virus Res Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: New York, NY : Academic Press |
| MeSH Terms: | Swine Diseases*/immunology ; Swine Diseases*/virology ; Hemorrhagic Fever, Ebola*/immunology ; Hemorrhagic Fever, Ebola*/virology ; Reoviridae Infections*/immunology ; Reoviridae Infections*/veterinary ; Reoviridae Infections*/virology; Lung/immunology ; Lung/virology ; Cytokines/immunology ; Cytokines/genetics ; Lymph Nodes/immunology ; Lymph Nodes/virology ; Animals ; Swine ; Disease Models, Animal ; Adaptive Immunity |
| Abstract: | Domestic pigs are a vital component of the global food supply, with a population nearing 780 million worldwide, making them one of the most commonly raised livestock. As pig production intensifies, the associated practices and environmental conditions may elevate the risk of emergence and spread of zoonotic agents, including ebolaviruses. Previously, we demonstrated that experimentall infection with Orthoebolavirus bundibugyoense and Orthoebolavirus restonense in pigs caused sub-clinical signs, with only a few animals exhibiting elevated temperatures and limited signs of acute respiratory distress. In this study, we sought to describe immune-related gene exression changes following those viral infections in pigs. Our findings revealed no significant changes in infection- and inflammation-related cytokines, but a strong adaptive immune response was observed in the lungs and tracheobronchial lymph nodes. Comparative analysis with a study in which non-human primates were experimentally infected with Orthoebolavirus bundibugyoense, where the virus is lethal, revealed molecular similarities in gene expression. This may suggest that certain viral processes may be conserved across species. These results highlight the potential role of pigs in ebolavirus spillover dynamics and underscore the importance of understanding the role of livestock in the emergence of these pathogens to guide prevention and mitigation strategies.; (Copyright © 2025. Published by Elsevier Inc.) |
| Contributed Indexing: | Keywords: Bundibugyo virus; Cytokine; Ebola virus; Multi-tissue molecular profiling; RNA-seq; Restin virus; Swine model |
| Substance Nomenclature: | 0 (Cytokines) |
| Entry Date(s): | Date Created: 20250723 Date Completed: 20250723 Latest Revision: 20250723 |
| Update Code: | 20260130 |
| DOI: | 10.1016/bs.aivir.2025.03.002 |
| PMID: | 40701749 |
| Database: | MEDLINE |
Journal Article