Advancements in Nanotechnology for Spinal Surgery: Innovations in Spinal Fixation Devices for Enhanced Biomechanical Performance and Osteointegration.
| Title: | Advancements in Nanotechnology for Spinal Surgery: Innovations in Spinal Fixation Devices for Enhanced Biomechanical Performance and Osteointegration. |
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| Authors: | Costăchescu B; Department of Neurosurgery, 'Gr. T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania.; 'Prof. Dr. N. Oblu' Emergency Clinical Hospital, 700309 Iasi, Romania.; Moldoveanu ET; Department of Science and Engineering of Oxide Materials and Nanomaterials, Politehnica University of Bucharest, 011061 Bucharest, Romania.; Niculescu AG; Department of Science and Engineering of Oxide Materials and Nanomaterials, Politehnica University of Bucharest, 011061 Bucharest, Romania.; Research Institute of the University of Bucharest-ICUB, University of Bucharest, 050657 Bucharest, Romania.; Grumezescu AM; Department of Science and Engineering of Oxide Materials and Nanomaterials, Politehnica University of Bucharest, 011061 Bucharest, Romania.; Research Institute of the University of Bucharest-ICUB, University of Bucharest, 050657 Bucharest, Romania.; Teleanu DM; Department of Neuroscience, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania. |
| Source: | Nanomaterials (Basel, Switzerland) [Nanomaterials (Basel)] 2025 Jul 10; Vol. 15 (14). Date of Electronic Publication: 2025 Jul 10. |
| Publication Type: | Journal Article; Review |
| Language: | English |
| Journal Info: | Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101610216 Publication Model: Electronic Cited Medium: Print ISSN: 2079-4991 (Print) Linking ISSN: 20794991 NLM ISO Abbreviation: Nanomaterials (Basel) Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: Basel, Switzerland : MDPI AG, [2011]- |
| Abstract: | Spinal injuries have a major impact on patients' quality of life due to the implacable consequences they bring, such as reduced mobility and loss of flexibility, in most cases requiring surgery to restore spinal stability and functionality. In this respect, spinal fixation devices represent an important strategy to stabilize the spine after severe injuries or degenerative conditions, providing structural support and preserving spinal function. However, at the moment, the materials used to manufacture spinal implants present numerous disadvantages (e.g., Young's modulus larger than cortical bone, which can produce bone resorption and implant enlargement) that can lead to implant failure. In this context, nanotechnology can offer promising solutions, bringing improved properties (e.g., biocompatibility, osseointegration, and increased mechanical performance) that increase the potential for obtaining devices customized to patients' needs. Thus, the present work aims to present an overview of the types of nanocoating surface modification, the impact of rough and porous implant surfaces, and the integration of bioactive nanoparticles that reduce the risk of infection and implant rejection. In addition, incorporating 3D printing technology and the use of biodegradable materials into the discussion provides a valuable perspective for future studies in this field. Although the emerging results are encouraging, further studies to assess the long-term safety of implant coatings are needed. |
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| Contributed Indexing: | Keywords: nanotechnology; osteointegration; rods; screws; spinal fixation devices; spinal implants |
| Entry Date(s): | Date Created: 20250725 Latest Revision: 20250729 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC12300515 |
| DOI: | 10.3390/nano15141073 |
| PMID: | 40711192 |
| Database: | MEDLINE |
Journal Article; Review