Addressing global diversity in dementia research with the COSMIC collaboration.
| Title: | Addressing global diversity in dementia research with the COSMIC collaboration. |
|---|---|
| Authors: | Lipnicki DM; Centre for Healthy Brain Ageing (CHeBA), UNSW Sydney, Sydney, NSW, Australia. Electronic address: d.lipnicki@unsw.edu.au.; Vella AS; Centre for Healthy Brain Ageing (CHeBA), UNSW Sydney, Sydney, NSW, Australia.; Jiang J; Centre for Healthy Brain Ageing (CHeBA), UNSW Sydney, Sydney, NSW, Australia.; Mewton L; The Matilda Centre for Research in Mental Health and Substance Use, The University of Sydney, Sydney, NSW, Australia.; Matison AP; Centre for Healthy Brain Ageing (CHeBA), UNSW Sydney, Sydney, NSW, Australia.; Mather KA; Centre for Healthy Brain Ageing (CHeBA), UNSW Sydney, Sydney, NSW, Australia.; Thalamuthu A; Centre for Healthy Brain Ageing (CHeBA), UNSW Sydney, Sydney, NSW, Australia.; Catts VS; Centre for Healthy Brain Ageing (CHeBA), UNSW Sydney, Sydney, NSW, Australia.; Chen R; Centre for Healthy Brain Ageing (CHeBA), UNSW Sydney, Sydney, NSW, Australia.; Husein N; Centre for Healthy Brain Ageing (CHeBA), UNSW Sydney, Sydney, NSW, Australia.; Wen W; Centre for Healthy Brain Ageing (CHeBA), UNSW Sydney, Sydney, NSW, Australia.; Kochan NA; Centre for Healthy Brain Ageing (CHeBA), UNSW Sydney, Sydney, NSW, Australia.; Crawford JD; Centre for Healthy Brain Ageing (CHeBA), UNSW Sydney, Sydney, NSW, Australia.; Sachdev PS; Centre for Healthy Brain Ageing (CHeBA), UNSW Sydney, Sydney, NSW, Australia. |
| Source: | Neuroscience [Neuroscience] 2025 Aug 30; Vol. 582, pp. 180-194. Date of Electronic Publication: 2025 Jul 24. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Elsevier Science Country of Publication: United States NLM ID: 7605074 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7544 (Electronic) Linking ISSN: 03064522 NLM ISO Abbreviation: Neuroscience Subsets: MEDLINE |
| Imprint Name(s): | Publication: [New York?] : Elsevier Science; Original Publication: Oxford, Elmsford, N. Y., Pergamon Press |
| MeSH Terms: | Dementia*/epidemiology ; Biomedical Research* ; International Cooperation*; Humans ; Cohort Studies ; Risk Factors |
| Abstract: | There is a need to study dementia risk factors more equitably across high-income countries (HICs) and low- and middle-income countries (LMICs). Cohort Studies of Memory in an International Consortium (COSMIC) is doing this by bringing together cohort studies of cognitive ageing from around the world to study dementia risk factors in a truly international way. COSMIC researchers have investigated a wide range of dementia risk factors across the diverse member studies and shown that some factors have different levels of association with dementia in different regions and populations. These differences include some cardiovascular and lifestyle factors having stronger associations with cognitive decline and dementia among Asian people than among White people. Conversely, more social factors were associated with reduced chances of mild cognitive impairment or dementia among Asian people than among White people. Interventions to prevent or delay dementia will require tailoring to optimise the local effect. COSMIC is currently developing methods to reliably assess dementia from limited data in under-resourced regions, producing dementia risk models appropriate for LMICs, and increasing its attention to genetics, biomarkers, and environmental factors across diverse regions and populations. Further, COSMIC is helping to train new researchers in LMICs, and COSMIC members are among the first to be boarded on Dementias Platform Australia, a secure data exchange platform facilitating cohort study data access by researchers anywhere in the world. We invite cohort studies from LMICs or under-studied populations to join COSMIC and help make dementia research as globally representative and collaborative as possible.; (Copyright © 2025 The Author(s). Published by Elsevier Inc. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
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| Grant Information: | R01 AG057531 United States AG NIA NIH HHS |
| Contributed Indexing: | Keywords: Cognitive decline; Cohort study; Ethnicity; International; LMIC; Risk factors |
| Entry Date(s): | Date Created: 20250727 Date Completed: 20250913 Latest Revision: 20260514 |
| Update Code: | 20260514 |
| PubMed Central ID: | PMC12365375 |
| DOI: | 10.1016/j.neuroscience.2025.07.036 |
| PMID: | 40714148 |
| Database: | MEDLINE |
Journal Article