Outcomes in diabetic vs nondiabetic patients requiring cardiac resynchronization therapy for heart failure: A meta-analysis.
| Title: | Outcomes in diabetic vs nondiabetic patients requiring cardiac resynchronization therapy for heart failure: A meta-analysis. |
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| Authors: | Goyal A; Department of Internal Medicine, Seth GS Medical College and KEM Hospital, Mumbai, India.; Department of Critical Care Medicine, Alchemist Hospitals, Panckula, India.; Tariq MD; Department of Internal Medicine, Foundation University Medical College, Islamabad, Pakistan.; Khan AM; Department of Internal Medicine, Ayub Medical College, Abbottabad, Pakistan.; Hurjkaliani S; Department of Internal Medicine, Dow University of Health Sciences, Karachi, Pakistan.; Ahsan A; Department of Internal Medicine, Foundation University Medical College, Islamabad, Pakistan.; Saeed H; Department of Internal Medicine, Rawalpindi Medical University, Rawalpindi, Pakistan.; Trivedi R; Department of Nephrology, Seth GS Medical College and KEM Hospital, Mumbai, India.; Mahalwar G; Department of Internal Medicine, Cleveland Clinic Foundation, Cleveland, Ohio.; Daoud M; Department of Internal Medicine, Bogomolets National Medical University, Kyiv, Ukraine.; Belur AD; Department of Cardiovascular Medicine, University of Alabama at Birmingham, Birmingham, Alabama. |
| Source: | Heart rhythm O2 [Heart Rhythm O2] 2025 Mar 05; Vol. 6 (6), pp. 753-765. Date of Electronic Publication: 2025 Mar 05 (Print Publication: 2025). |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Elsevier Inc Country of Publication: United States NLM ID: 101768511 Publication Model: eCollection Cited Medium: Internet ISSN: 2666-5018 (Electronic) Linking ISSN: 26665018 NLM ISO Abbreviation: Heart Rhythm O2 Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: [New York] : Elsevier Inc., [2020]- |
| Abstract: | Background: Heart failure (HF) affects millions globally, causing severe symptoms and poor prognosis. Cardiac resynchronization therapy (CRT) has been shown to improve heart function and quality of life in HF patients with electrical dyssynchrony, but its effectiveness in diabetic patients remains unclear due to the complexities associated with diabetes.; Objective: This study evaluates the impact of diabetes mellitus on CRT by comparing outcomes between diabetic and nondiabetic patients through a meta-analysis.; Methods: A comprehensive literature search identified studies on CRT in HF patients both with and without diabetes mellitus. Pooled risk ratios (RRs) and mean differences were calculated using a random-effects model with 95% confidence intervals and statistical significance set at P < .05.; Results: Analysis of 13 observational studies involving 20,073 participants revealed that diabetic patients had a significantly increased risk of all-cause mortality (RR 1.34, P < .00001) and cardiovascular death (RR 1.49, P = .002) compared with nondiabetic patients. However, no statistically significant differences were observed between groups in the risk of stroke (RR 3.99, P = .05), myocardial infarction (RR 1.16, P = .30), changes in left ventricular (LV) ejection fraction (P = .22), LV end-systolic volume (P = .10), and LV end-diastolic volume (P = .63).; Conclusion: These findings suggest that diabetic patients undergoing CRT face a higher risk of all-cause and cardiovascular mortality compared with nondiabetic patients. The increased mortality risk highlights the need for tailored treatment strategies, emphasizing the judicious use of CRT in diabetic patients.; (© 2025 Heart Rhythm Society. Published by Elsevier Inc.) |
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| Contributed Indexing: | Keywords: CRT; Cardiac resynchronization therapy; Diabetes mellitus; Heart failure; Mortality |
| Entry Date(s): | Date Created: 20250728 Latest Revision: 20250731 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC12287962 |
| DOI: | 10.1016/j.hroo.2025.02.020 |
| PMID: | 40717852 |
| Database: | MEDLINE |
Journal Article