Insights into the pharmaceutical properties of green fabricated Iron oxide nanoparticles.
| Title: | Insights into the pharmaceutical properties of green fabricated Iron oxide nanoparticles. |
|---|---|
| Authors: | Al-Salman HNK; Department of Pharmaceutical Chemistry, College of Pharmacy, University of Basrah, Basrah, Iraq.; Qasim QA; College of Pharmacy, Al-Ayen University, Dhi Qar, Iraq.; Abbas BA; Department of Microbiology, College of Veterinary Medicine, University of Basrah, Basrah, Iraq.; Hussein AJ; Department of Microbiology, College of Veterinary Medicine, University of Basrah, Basrah, Iraq.; Shari FH; Department of Clinical Laboratory Sciences, College of Pharmacy, University of Basrah, Basrah, Iraq.; Jabir MS; Department of Applied Sciences, University of Technology, Baghdad, Iraq. 100131@uotechnology.edu.iq.; Gatasheh MK; Department of Biochemistry, College of Science, King Saud University, P.O. Box-2455, Riyadh, 11451, Saudi Arabia. mgatasheh@ksu.edu.sa.; Al-Farga A; State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, 214122, Jiangsu, China.; Fawzi HA; Department of Clinical Pharmacy, College of Pharmacy, AlMustafa University, Baghdad, Iraq. hayder.adnan2010@gmail.com. |
| Source: | Scientific reports [Sci Rep] 2025 Jul 29; Vol. 15 (1), pp. 27621. Date of Electronic Publication: 2025 Jul 29. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: London : Nature Publishing Group, copyright 2011- |
| MeSH Terms: | Plant Extracts*/chemistry ; Plant Extracts*/pharmacology ; Magnetic Iron Oxide Nanoparticles*/chemistry ; Ferric Compounds*/chemistry ; Ferric Compounds*/pharmacology; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Antioxidants/pharmacology ; Antioxidants/chemistry ; Antiviral Agents/pharmacology ; Antiviral Agents/chemistry ; Onions/chemistry ; Staphylococcus aureus/drug effects ; Escherichia coli/drug effects ; Reactive Oxygen Species/metabolism ; Animals ; Dogs ; Green Chemistry Technology ; Madin Darby Canine Kidney Cells ; Microbial Sensitivity Tests |
| Abstract: | Researchers have recently grown interested in utilizing plant extracts as effective reducing agents for the eco-friendly synthesis of nanoparticles. The present investigation involved the preparation of Iraqi onion extract (Allium cepa), which was further utilized as a reducing agent for the biosynthesis of Fe3O4-nanoparticles (NPs). Characterization of nanoparticles was conducted using UV-visible spectroscopy, TEM, XRD, FT-IR, FESEM, and EDS analyses. The in vitro cytotoxicity was assessed in MDCK-SIAT cells utilizing the MTT assay, while the antiviral efficacy was examined with the neuraminidase assay kit MAK12. Antibacterial efficacy was examined against S. aureus and E. coli utilizing a disk-diffusion methodology. The DPPH assay was employed to evaluate antioxidant activity. The impact of A. cepa extract and Fe3O4-NPs on phagocytic cell activity was evaluated. Our findings demonstrated the production of solid, crystalline, semi-spherical Fe3O4 measuring 36 ± 1.23 nm, exhibiting significant antibacterial, antiviral, and antioxidant properties. A. cepa extract and Fe3O4-NPs can augment the phagocytic activity of phagocytic cells by elevating the formation of reactive oxygen species. In conclusion, Onion peel extract is a superior option for synthesizing Fe3O4-NPs, which may be employed in many therapeutic applications in the future.; (© 2025. The Author(s).) |
| Competing Interests: | Declarations. Competing interests: The authors declare no competing interests. |
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| Grant Information: | ORF-2025-393 King Faisal University |
| Contributed Indexing: | Keywords: Antioxidant; Bactericidal; Green synthesis; Iron oxide nanoparticles; Onion peel extract; Phagocytosis |
| Substance Nomenclature: | 0 (Plant Extracts); 0 (Anti-Bacterial Agents); 0 (Antioxidants); 0 (Antiviral Agents); 1K09F3G675 (ferric oxide); 0 (Ferric Compounds); 0 (Reactive Oxygen Species) |
| Entry Date(s): | Date Created: 20250729 Date Completed: 20250730 Latest Revision: 20250801 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC12307748 |
| DOI: | 10.1038/s41598-025-09327-x |
| PMID: | 40730590 |
| Database: | MEDLINE |
Journal Article