Within and Beyond the Binary: Sex and Gender Differences in Pain and Alcohol Use Disorder.
| Title: | Within and Beyond the Binary: Sex and Gender Differences in Pain and Alcohol Use Disorder. |
|---|---|
| Authors: | Fitzpatrick-Schmidt T; Department of Physiology, LSU Health-New Orleans.; Alcohol & Drug Abuse Center of Excellence, LSU Health-New Orleans.; Comprehensive Alcohol-HIV/AIDS Research Center, LSU Health-New Orleans.; Edwards S; Department of Physiology, LSU Health-New Orleans.; Alcohol & Drug Abuse Center of Excellence, LSU Health-New Orleans.; Comprehensive Alcohol-HIV/AIDS Research Center, LSU Health-New Orleans. |
| Source: | Current addiction reports [Curr Addict Rep] 2024 Feb; Vol. 11 (1), pp. 68-80. Date of Electronic Publication: 2023 Dec 22. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Springer International Publishing AG Country of Publication: Switzerland NLM ID: 101623508 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2196-2952 (Print) NLM ISO Abbreviation: Curr Addict Rep Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: [Switzerland] : Springer International Publishing AG, [2014]- |
| Abstract: | Purpose of Review: Alcohol use disorder (AUD) and chronic pain are frequently comorbid conditions. This review aims to communicate recent research describing the bidirectional effects of pain experience and alcohol use, while focusing on sex and gender differences at this intersection with an emphasis on translational research.; Recent Findings: Most pain syndromes affect people assigned female at birth (AFAB). Although people assigned male at birth (AMAB) typically drink more than AFABs, AFABs progress to AUD more quickly and experience more alcohol-related comorbidities. In the preclinical setting, different alcohol models highlight sex differences in the escalation of alcohol drinking, while a state of alcohol dependence appears to produce sex-specific alterations in withdrawal-induced pain- and anxiety-like behaviors.; Summary: Preclinical and clinical studies are accelerating in order to elucidate important sex differences in both chronic pain and AUD. A better understanding of the physiological mechanisms underlying pain and AUD will support the discovery of more effective, potentially sex-specific, therapeutic options for these devastating co-morbid conditions. |
| Competing Interests: | Conflict of Interest: The authors have no conflict of interest to declare. |
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| Grant Information: | P60 AA009803 United States AA NIAAA NIH HHS; F30 AA030941 United States AA NIAAA NIH HHS; T35 AA021097 United States AA NIAAA NIH HHS; P50 AA009803 United States AA NIAAA NIH HHS; T32 AA007577 United States AA NIAAA NIH HHS; R01 AA025996 United States AA NIAAA NIH HHS |
| Contributed Indexing: | Keywords: alcohol use disorder; analgesia; chronic pain; hyperalgesia; sex differences; translational |
| Entry Date(s): | Date Created: 20250801 Latest Revision: 20250805 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC12312634 |
| DOI: | 10.1007/s40429-023-00534-y |
| PMID: | 40747361 |
| Database: | MEDLINE |
Journal Article