Preparing for Future Pandemics: Vaccine Effectiveness Against SARS-CoV-2 Variant in a High-Risk Hospital Environment-A Case Study From Vietnam.
| Title: | Preparing for Future Pandemics: Vaccine Effectiveness Against SARS-CoV-2 Variant in a High-Risk Hospital Environment-A Case Study From Vietnam. |
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| Authors: | Nguyen HT; Department of Communicable Disease Control, National Institute of Hygiene and Epidemiology, Hanoi, Vietnam.; National Centre for Epidemiology and Population Health, College of Law, Governance and Policy, Australian National University, Canberra, ACT, Australia.; Duong LH; Department of Medical Service Administration, Ministry of Health, Hanoi, Vietnam.; Pham TQ; Department of Communicable Disease Control, National Institute of Hygiene and Epidemiology, Hanoi, Vietnam.; School of Preventive Medicine and Public Health, Hanoi Medical University, Hanoi, Vietnam.; Dao TH; Hanoi Center for Disease Control, Hanoi, Vietnam.; Nguyen KT; Hanoi Center for Disease Control, Hanoi, Vietnam.; Nguyen HT; Department of Communicable Disease Control, National Institute of Hygiene and Epidemiology, Hanoi, Vietnam.; National Centre for Epidemiology and Population Health, College of Law, Governance and Policy, Australian National University, Canberra, ACT, Australia.; Ngu ND; Department of Communicable Disease Control, National Institute of Hygiene and Epidemiology, Hanoi, Vietnam.; Tran DN; National Institute of Hygiene and Epidemiology, Hanoi, Vietnam.; Le KT; Viet Duc University Hospital, Hanoi, Vietnam.; Trinh TS; Oxford University Clinical Research Unit, Hanoi, Vietnam.; Doorn HRV; Oxford University Clinical Research Unit, Hanoi, Vietnam.; Vogt F; National Centre for Epidemiology and Population Health, College of Law, Governance and Policy, Australian National University, Canberra, ACT, Australia.; The Kirby Institute, University of New South Wales, Sydney, NSW, Australia.; Nguyen KC; Department of Communicable Disease Control, National Institute of Hygiene and Epidemiology, Hanoi, Vietnam.; Field Epidemiology Training Program, National Institute of Hygiene and Epidemiology, Hanoi, Vietnam. |
| Source: | Asia-Pacific journal of public health [Asia Pac J Public Health] 2025 Nov; Vol. 37 (8), pp. 681-689. Date of Electronic Publication: 2025 Aug 09. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: SAGE Publications Country of Publication: China NLM ID: 8708538 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1941-2479 (Electronic) Linking ISSN: 10105395 NLM ISO Abbreviation: Asia Pac J Public Health Subsets: MEDLINE |
| Imprint Name(s): | Publication: Hong Kong : SAGE Publications; Original Publication: [Hong Kong] : Science Press, c1987- |
| MeSH Terms: | COVID-19*/prevention & control ; COVID-19*/epidemiology ; COVID-19 Vaccines*/administration & dosage ; Pandemics*/prevention & control ; Vaccine Efficacy*; Vietnam/epidemiology ; Humans ; Male ; Female ; Middle Aged ; Adult ; SARS-CoV-2 ; Aged ; Young Adult ; Adolescent |
| Abstract: | On 30 September 2021, Viet Duc University Hospital in Northern Vietnam, reported a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta outbreak, leading to an 18-day lockdown and repeated testing of all on-site individuals. At this time, SARS-CoV-2 was not yet circulating at scale among the general public and COVID-19 vaccination status varied among staff, patients, and caregivers. We estimated vaccine effectiveness (VE), attack rates (ARs), and adjusted risk ratios (aRRs) to identify factors associated with infection among infection-naïve patients, caregivers, and staff using multivariable regression analysis. Among 630 at-risk individuals, there were 131 (21%) polymerase chain reaction (PCR)-confirmed COVID-19 cases including three deaths. The overall VE was 78%. Hospital staff and people who were fully vaccinated had a significantly lower risk of SARS-CoV-2 infection (P < .05). Our analysis shows the importance of being fully vaccinated in reducing the risk of SARS-CoV-2 infection in hospital settings. |
| Competing Interests: | Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. |
| Contributed Indexing: | Keywords: SARS-CoV-2; health care-associated infections; hospital; nosocomial infections; vaccine effectiveness |
| Substance Nomenclature: | 0 (COVID-19 Vaccines) |
| SCR Organism: | SARS-CoV-2 variants |
| Entry Date(s): | Date Created: 20250809 Date Completed: 20251211 Latest Revision: 20251211 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC12681362 |
| DOI: | 10.1177/10105395251360136 |
| PMID: | 40782037 |
| Database: | MEDLINE |
Journal Article