Medullary thyroid cancer arising from a thyroid rest: a case report.
| Title: | Medullary thyroid cancer arising from a thyroid rest: a case report. |
|---|---|
| Authors: | Beiriger J; Department of Otolaryngology - Head and Neck Surgery, University of Utah School of Medicine, 30 N. Mario Capecchi Drive, 4th Floor, Salt Lake City, UT 84112, United States.; McCrary HC; Department of Otolaryngology - Head and Neck Surgery, University of Utah School of Medicine, 30 N. Mario Capecchi Drive, 4th Floor, Salt Lake City, UT 84112, United States.; Carpenter P; Department of Otolaryngology - Head and Neck Surgery, University of Utah School of Medicine, 30 N. Mario Capecchi Drive, 4th Floor, Salt Lake City, UT 84112, United States.; Witt BL; Department of Pathology, University of Utah School of Medicine, 15 North Medical Drive East, Ste. #1100, Salt Lake City, UT 84112, United States.; Abraham D; Department of Internal Medicine, Division of Endocrinology, University of Utah School of Medicine, 30 North Mario Capecchi Dr, 3rd Floor North, Salt Lake City, UT 84112, United States.; Monroe MM; Department of Otolaryngology - Head and Neck Surgery, University of Utah School of Medicine, 30 N. Mario Capecchi Drive, 4th Floor, Salt Lake City, UT 84112, United States. |
| Source: | Journal of surgical case reports [J Surg Case Rep] 2025 Aug 10; Vol. 2025 (8), pp. rjaf613. Date of Electronic Publication: 2025 Aug 10 (Print Publication: 2025). |
| Publication Type: | Case Reports; Journal Article |
| Language: | English |
| Journal Info: | Publisher: Oxford University Press Country of Publication: England NLM ID: 101560169 Publication Model: eCollection Cited Medium: Print ISSN: 2042-8812 (Print) Linking ISSN: 20428812 NLM ISO Abbreviation: J Surg Case Rep Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Publication: 2013- : Oxford : Oxford University Press; Original Publication: 2010-2012: Halesowen, UK : JSCR Publishing Limited |
| Abstract: | Medullary thyroid carcinoma (MTC) is rare and originates from parafollicular C cells and most cases present with a primary thyroid lesion. This report describes a 67-year-old woman with a left-sided neck mass and no evidence of intrathyroidal disease. Positron emission tomography-computed tomography (PET-CT) revealed paratracheal lymphadenopathy; other imaging and TSH were unremarkable. Fine-needle aspiration was inconclusive, and excisional biopsy suggested high-grade metastatic neuroendocrine carcinoma, initially suspected to be pulmonary due to thyroid transcription factor-1 (TTF-1) positivity. Pathology review raised concern for MTC. Endocrine evaluation showed elevated calcitonin (25.4 pg/ml) and carcinoembryonic antigen (CEA) (20.1 ng/ml). She denied personal or family history of thyroid disease or multiple endocrine neoplasia syndromes. Total thyroidectomy with central neck dissection was performed. All thyroid sections stained negative for calcitonin, excluding C cell hyperplasia or intrathyroidal MTC. Lymph node morphology and immunoprofile supported metastatic MTC arising from a thyroid rest. This is a rare entity, with only two other cases documented in the literature.; (© The Author(s) 2025. Published by Oxford University Press and JSCR Publishing Ltd.) |
| Competing Interests: | None to disclose. |
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| Contributed Indexing: | Keywords: medullary thyroid carcinoma; neuroendocrine tumors; thyroid rest |
| Entry Date(s): | Date Created: 20250813 Latest Revision: 20250816 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC12342817 |
| DOI: | 10.1093/jscr/rjaf613 |
| PMID: | 40800658 |
| Database: | MEDLINE |
Case Reports; Journal Article