Prenatal cannabis exposure, the brain, and psychopathology during early adolescence.
| Title: | Prenatal cannabis exposure, the brain, and psychopathology during early adolescence. |
|---|---|
| Authors: | Baranger DA; Department of Psychological and Brain Sciences, Washington University in St Louis, St Louis, Missouri.; Miller AP; Department of Psychiatry, Washington University School of Medicine in St Louis, St Louis, Missouri.; Gorelik AJ; Department of Psychological and Brain Sciences, Washington University in St Louis, St Louis, Missouri.; Paul SE; Department of Psychological and Brain Sciences, Washington University in St Louis, St Louis, Missouri.; Hatoum AS; Department of Psychological and Brain Sciences, Washington University in St Louis, St Louis, Missouri.; Johnson EC; Department of Psychiatry, Washington University School of Medicine in St Louis, St Louis, Missouri.; Colbert SM; Department of Psychiatry, Washington University School of Medicine in St Louis, St Louis, Missouri.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Smyser CD; Department of Neurology, Washington University School of Medicine, St Louis, MO, USA.; Department of Radiology, Washington University School of Medicine, St Louis, MO, USA.; Department of Pediatrics, Washington University School of Medicine, St Louis, MO, USA.; Rogers CE; Department of Psychiatry, Washington University School of Medicine in St Louis, St Louis, Missouri.; Department of Pediatrics, Washington University School of Medicine, St Louis, MO, USA.; Bijsterbosch JD; Department of Radiology, Washington University School of Medicine, St Louis, MO, USA.; Agrawal A; Department of Psychiatry, Washington University School of Medicine in St Louis, St Louis, Missouri.; Bogdan R; Department of Psychological and Brain Sciences, Washington University in St Louis, St Louis, Missouri. |
| Source: | Nature. Mental health [Nat Ment Health] 2024 Aug; Vol. 2 (8), pp. 975-986. Date of Electronic Publication: 2024 Jul 04. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Springer Nature Country of Publication: England NLM ID: 9918486688806676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2731-6076 (Electronic) Linking ISSN: 27316076 NLM ISO Abbreviation: Nat Ment Health Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: [London] : Springer Nature, [2023]- |
| Abstract: | Prenatal cannabis exposure (PCE) is associated with mental health problems in early adolescence, but the possible neurobiological mechanisms remain unknown. In a large longitudinal sample of adolescents (ages 9-12, n=9,322-10,186), we find that PCE is associated with localized differences in gray and white matter of the frontal and parietal cortices, their associated white matter tracts, and with striatal resting state connectivity, even after accounting for potential pregnancy, familial, and child confounds. Variability in forceps minor and pars triangularis diffusion metrics partially longitudinally mediate PCE-ADHD associations. PCE-related differences in brain development may confer vulnerability to worse mental health in early adolescence. |
| Comments: | Update of: medRxiv. 2023 Oct 17:2023.09.19.23295792. doi: 10.1101/2023.09.19.23295792.. (PMID: 37790406) |
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| Grant Information: | U24 DA041147 United States DA NIDA NIH HHS; U01 DA041120 United States DA NIDA NIH HHS; R21 AA027827 United States AA NIAAA NIH HHS; R01 DA054750 United States DA NIDA NIH HHS; U01 DA055367 United States DA NIDA NIH HHS; U24 DA041123 United States DA NIDA NIH HHS; F31 AA029934 United States AA NIAAA NIH HHS; U01 DA041156 United States DA NIDA NIH HHS; K01 DA051759 United States DA NIDA NIH HHS; K01 AA030083 United States AA NIAAA NIH HHS; U01 DA041025 United States DA NIDA NIH HHS; U01 DA041089 United States DA NIDA NIH HHS; U01 DA041106 United States DA NIDA NIH HHS; U01 DA041117 United States DA NIDA NIH HHS; R01 DA046224 United States DA NIDA NIH HHS; U01 DA041174 United States DA NIDA NIH HHS; K99 AA030808 United States AA NIAAA NIH HHS; U01 DA041093 United States DA NIDA NIH HHS; U01 DA041134 United States DA NIDA NIH HHS; U01 DA041022 United States DA NIDA NIH HHS; U01 DA041028 United States DA NIDA NIH HHS; U01 DA041048 United States DA NIDA NIH HHS; T32 DA015035 United States DA NIDA NIH HHS; U01 DA041148 United States DA NIDA NIH HHS |
| Entry Date(s): | Date Created: 20250821 Latest Revision: 20250825 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC12363474 |
| DOI: | 10.1038/s44220-024-00281-7 |
| PMID: | 40836962 |
| Database: | MEDLINE |
Journal Article