Comparing Antemortem CT-Angiography Data with Autopsy Findings in Regard to Anterior Communicating Artery Aneurysms.
| Title: | Comparing Antemortem CT-Angiography Data with Autopsy Findings in Regard to Anterior Communicating Artery Aneurysms. |
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| Authors: | Dumitrescu AM; Department of Morpho-Functional Sciences I, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania.; Chiran DA; Department of Morpho-Functional Sciences I, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania.; Stan CI; Department of Morpho-Functional Sciences I, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania.; Paraschiv CM; Department of Medical Sciences I, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania.; Internal Medicine Clinic, Clinical CF Hospital, 700506 Iasi, Romania.; Dobrin N; Neurointerventional Surgery Department, 'Prof. Dr. N. Oblu' Emergency Clinical Hospital, 700309 Iasi, Romania.; Chiriac A; Neurointerventional Surgery Department, 'Prof. Dr. N. Oblu' Emergency Clinical Hospital, 700309 Iasi, Romania.; Department of Surgery II, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania.; Leon MM; Department of Medical Sciences I, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania.; Dima-Cozma LC; Department of Medical Sciences I, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania.; Dascalu CG; Department of Medical Informatics and Biostatistics, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania.; Radulescu AM; Department of Morpho-Functional Sciences I, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania.; Gavril RF; Department of Morpho-Functional Sciences I, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania.; Sava A; Department of Morpho-Functional Sciences I, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania.; Department of Pathology, 'Prof. Dr. N. Oblu' Emergency Clinical Hospital, 700309 Iasi, Romania. |
| Source: | NeuroSci [NeuroSci] 2025 Aug 18; Vol. 6 (3). Date of Electronic Publication: 2025 Aug 18. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101772310 Publication Model: Electronic Cited Medium: Internet ISSN: 2673-4087 (Electronic) Linking ISSN: 26734087 NLM ISO Abbreviation: NeuroSci Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: [Basel] : MDPI AG, [2020]- |
| Abstract: | Background: The literature shows that anterior communicating artery (AcoA) aneurysms are the most common intracranial aneurysms. To date, there has only been one postmortem study focused on the correlations between autopsy findings and imaging results in cases of intracranial aneurysms associated with anatomical variants of the circle of Willis (CW).; Methods: We investigated the anatomical variants of the CW associated with the occurrence and rupture of AcoA aneurysms by performing comparative analyses, in the same patients, of postmortem autopsy data with antemortem computed tomography-angiography (CTA) results obtained in the first 48 h after the onset of subarachnoid hemorrhage. Our retrospective observational study identified the anatomical variants of the CW at autopsy in 16 deceased adult Romanian patients with AcoA aneurysms over a 12-year period (2010-2022).; Results: The autopsy findings revealed that the AcoA ruptured aneurysms had a mean external diameter of 9.50 mm, and 71.4% of them presented three or four anatomical variants inside the same CW. The initial antemortem CTA examination correctly located the AcoA aneurysms in all cases (100%), and an anatomical variant of the CW was only noted in 18.75% of patients. The final postmortem re-analyzed the same CTA images identified in all cases (100%), focusing on both the AcoA aneurysm and all anatomical variants of the CW found during the autopsies.; Conclusions: Although it was previously thought that the occurrence of AcoA aneurysms is related only to the hemodynamic changes induced by the nearby arterial anatomical variants, we identified the simultaneous involvement of at least one hypoplastic artery and one or two PCA fetal-type anatomical variants that were located in both the anterior and posterior parts of the CW. Furthermore, if sufficient time is devoted to the CT-angiography analysis and interpretation of the images, anatomical variants of the circle of Willis associated with AcoA aneurysms can be identified as accurately as they are in invasive postmortem autopsy examinations. |
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| Contributed Indexing: | Keywords: 3D reconstruction; anatomical variant; anterior communicating artery aneurysm; autopsy; circle of Willis; computed tomography angiography |
| Entry Date(s): | Date Created: 20250822 Date Completed: 20250914 Latest Revision: 20250926 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC12371958 |
| DOI: | 10.3390/neurosci6030081 |
| PMID: | 40843697 |
| Database: | MEDLINE |
Journal Article