Evaluation of Serum Complement Components in Pediatric IgA Vasculitis: A Case-Control Study.
| Title: | Evaluation of Serum Complement Components in Pediatric IgA Vasculitis: A Case-Control Study. |
|---|---|
| Authors: | Taşkın RB; Department of Pediatric Rheumatology, Faculty of Medicine, Health Sciences University Tepecik Training and Research Hospital, Konak, Izmir 35020, Turkey.; Aksu G; Department of Pediatric Rheumatology and Immunology, Faculty of Medicine, Ege University, Bornova, Izmir 35100, Turkey.; Şen S; Department of Pathology, Faculty of Medicine, Ege University, Bornova, Izmir 35100, Turkey.; Hakverdi G; Department of Biostatistics, Faculty of Medicine, Cumhuriyet University, Sivas 58140, Turkey.; Dörtkardeşler BE; Department of Pediatrics, Faculty of Medicine, Ege University, Bornova, Izmir 35100, Turkey.; Conkar Tunçay S; Department of Pediatric Nephrology, Faculty of Medicine, Ege University, Bornova, Izmir 35100, Turkey. |
| Source: | Children (Basel, Switzerland) [Children (Basel)] 2025 Aug 20; Vol. 12 (8). Date of Electronic Publication: 2025 Aug 20. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101648936 Publication Model: Electronic Cited Medium: Print ISSN: 2227-9067 (Print) Linking ISSN: 22279067 NLM ISO Abbreviation: Children (Basel) Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: Basel, Switzerland : MDPI AG, [2014]- |
| Abstract: | Background: IgA vasculitis (IgAV) represents the most frequently seen form of vasculitis among children. Although it often resolves without intervention, renal involvement (IgAV nephritis) poses a risk for long-term complications. Although the lectin and alternative complement pathways are possible causes in its development, dependable serum biomarkers for the early identification of nephritis remain unavailable.; Methods: In this prospective case-control study, we examined how the serum levels of a membrane attack complex (sC5b-9), complement factor H (CFH), mannose-binding lectin (MBL), and mannose-binding lectin-associated serine protease-1 (MASP-1) relate to renal involvement in IgAV. These complement proteins were measured in children diagnosed with IgAV and compared to levels in healthy controls (HCs) matched for age and sex.; Results: The study cohort comprised 44 IgAV patients with a median age of 8 years and 34 HCs. The CFH levels were reduced significantly in the patient group (median: 357.31 ng/mL; IQR: 228.32) relative to the controls (median: 543.08 ng/mL; IQR: 504.05) (p < 0.001). This decrease was observed irrespective of the presence of nephritis. There were no significant differences in serum sC5b-9, MBL, or MASP-1 levels between the patients and controls. Furthermore, no correlation emerged between these complement components and renal involvement.; Conclusion: The data suggest that lower CFH levels may signal systemic dysregulation of the alternative pathway in IgAV. In contrast, the serum levels of sC5b-9, MBL, and MASP-1 appear inadequate as markers for predicting renal involvement. Further research with larger cohorts that includes genetic analyses and examination of kidney tissue is needed to better define the contribution of complement activation in IgAV-related nephritis. |
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| Grant Information: | 23640 Scientific Research Projects Unit of Ege University |
| Contributed Indexing: | Keywords: IgA vasculitis; complement factor H; nephritis; pediatrics |
| Entry Date(s): | Date Created: 20250828 Date Completed: 20250914 Latest Revision: 20250914 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC12384529 |
| DOI: | 10.3390/children12081090 |
| PMID: | 40868541 |
| Database: | MEDLINE |
Journal Article