Identification of Dementia With Lewy Bodies by Skin Biopsy in Recent-Onset Cognitive Impairment.
| Title: | Identification of Dementia With Lewy Bodies by Skin Biopsy in Recent-Onset Cognitive Impairment. |
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| Authors: | Furia A; Dipartimento di Scienze Biomediche e Neuromotorie, Università di Bologna, Bologna, Italy.; Incensi A; IRCCS Istituto delle Scienze Neurologiche di Bologna, UOC Clinica Neurologica, Bologna, Italy.; Delprete C; IRCCS Istituto delle Scienze Neurologiche di Bologna, UOC Clinica Neurologica, Bologna, Italy.; Rizzo G; IRCCS Istituto delle Scienze Neurologiche di Bologna, UOC Clinica Neurologica, Bologna, Italy.; Bonvegna S; ASST Centro Specialistico Ortopedico Traumatologico Gaetano Pini-CTO, UOC Centro per la Malattia di Parkinson e Parkinsonismi, Milano, Italy.; Piatti M; ASST Centro Specialistico Ortopedico Traumatologico Gaetano Pini-CTO, UOC Centro per la Malattia di Parkinson e Parkinsonismi, Milano, Italy.; Dipartimento di Neurologia, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.; Olivola E; IRCCS Istituto Neurologico Mediterraneo Neuromed, Pozzilli, Italy.; Ventruto F; Dipartimento di Scienze Biomediche e Neuromotorie, Università di Bologna, Bologna, Italy.; Vacchiano V; IRCCS Istituto delle Scienze Neurologiche di Bologna, UOC Clinica Neurologica, Bologna, Italy.; Fileccia E; Ospedale Santa Maria delle Croci, Ravenna, Italy.; Cilia R; Fondazione IRCCS Istituto Neurologico Carlo Besta, Centro Malattia di Parkinson e Disturbi del Movimento, Milan, Italy.; Modugno N; IRCCS Istituto Neurologico Mediterraneo Neuromed, Pozzilli, Italy.; Liguori R; Dipartimento di Scienze Biomediche e Neuromotorie, Università di Bologna, Bologna, Italy.; IRCCS Istituto delle Scienze Neurologiche di Bologna, UOC Clinica Neurologica, Bologna, Italy.; Donadio V; Dipartimento di Scienze Biomediche e Neuromotorie, Università di Bologna, Bologna, Italy.; IRCCS Istituto delle Scienze Neurologiche di Bologna, UOC Clinica Neurologica, Bologna, Italy. |
| Source: | Annals of clinical and translational neurology [Ann Clin Transl Neurol] 2025 Sep; Vol. 12 (9), pp. 1919-1925. Date of Electronic Publication: 2025 Aug 05. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Wiley Periodicals, Inc on behalf of American Neurological Association Country of Publication: United States NLM ID: 101623278 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2328-9503 (Electronic) Linking ISSN: 23289503 NLM ISO Abbreviation: Ann Clin Transl Neurol Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: [Hoboken, NJ] : Wiley Periodicals, Inc on behalf of American Neurological Association, [2014]- |
| MeSH Terms: | Lewy Body Disease*/diagnosis ; Lewy Body Disease*/pathology ; Lewy Body Disease*/metabolism ; Cognitive Dysfunction*/pathology ; Cognitive Dysfunction*/diagnosis ; Cognitive Dysfunction*/metabolism ; Skin*/pathology ; Skin*/metabolism ; alpha-Synuclein*/metabolism; Biomarkers/metabolism ; Humans ; Male ; Aged ; Female ; Pilot Projects ; Biopsy ; Middle Aged ; Aged, 80 and over |
| Abstract: | Immunofluorescence for phosphorylated alpha-synuclein in skin biopsy samples is an emerging biomarker in synucleinopathies comprising Dementia with Lewy bodies. In this pilot study, 19 patients with recent-onset (≤ 18 months) cognitive impairment underwent skin biopsy at baseline, with follow-up clinical re-evaluation. Five patients fulfilled the Dementia with Lewy bodies diagnosis, all of them positive for skin phosphorylated alpha-synuclein. The remaining 14 patients were all negative. Skin tissue immunofluorescence may represent a promising technique in identifying synuclein pathology in recent-onset cognitive decline: larger cohorts are needed to confirm our preliminary data.; (© 2025 The Author(s). Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.) |
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| Grant Information: | RF-2016-02362047 Ministero della Salute |
| Contributed Indexing: | Keywords: Lewy bodies; dementia; immunofluorescence; skin biopsy; synucleinopathy |
| Substance Nomenclature: | 0 (alpha-Synuclein); 0 (Biomarkers) |
| Entry Date(s): | Date Created: 20250829 Date Completed: 20250923 Latest Revision: 20250925 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC12455860 |
| DOI: | 10.1002/acn3.70133 |
| PMID: | 40878868 |
| Database: | MEDLINE |
Journal Article