A Multispecialty Consensus on Individualized Treatment Strategies for Hypertension Phenotypes and Comorbidities.
| Title: | A Multispecialty Consensus on Individualized Treatment Strategies for Hypertension Phenotypes and Comorbidities. |
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| Authors: | Wander GS; Professor and Head, Department of Cardiology, Dayanand Medical College and Hospital, Ludhiana, Punjab, India.; Tewary K; Former Professor and Head, Department of Medicine, Sri Krishna Medical College, Muzaffarpur, Bihar, India.; Muruganathan A; Senior Consultant Physician and Chairman, Department of Medicine, Shristi AG Hospital, Tiruppur, Tamil Nadu, India.; Vora AC; Chest Physician and Medical Director, Department of Pulmonology, Vora Clinic and Brahma Kumaris Global Hospital and Research Centre, Mumbai, Maharashtra, India.; Mathur G; Consultant Physician, Department of Medicine, Alka Diagnostic Centre, Kota, Rajasthan, India, Orcid: https://orcid.org/0000-0003-1484-7774.; Meenakshisundaram C; Consultant Cardiologist, Department of Cardiology, Heart Care Unit, Ramakrishna Nursing Home, Tiruchirappalli, Tamil Nadu, India.; Singh NP; Consultant Physician, Department of Nephrology, Max Super Speciality Hospital, Delhi; Dean, Department of Research, Eternal University, Rajgarh, Himachal Pradesh, India, Orcid: https://orcid.org/0000-0002-7065-8217.; Barman A; Director of Medical Education, Department of Nephrology, Government of Assam, Guwahati, Assam, India.; Prabhakar M; Senior Consultant Physician and Medical Director, Department of Medicine, IMA AKN Sinha Institute; Member at Governing Body, National API; Chairman, Research Society for the Study of Diabetes in India, Gurugram, Haryana, India.; Chatterjee N; Professor, Department of Internal Medicine, Institute of Post Graduate Medical Education and Research (IPGMER), Kolkata, West Bengal, India, Orcid: https://orcid.org/0000-0002-7729-812X.; Ghosh S; Professor, Department of Endocrinology, Institute of Post Graduate Medical Education and Research (IPGMER), Kolkata, West Bengal, India.; Saxena P; Consultant Physician and Senior Professor, Department of Medicine, Sawai Man Singh Medical College and Hospital, Jaipur, Rajasthan, India.; Mehta N; Associate Director, Department of Structural Heart, Jaslok Hospital and Research Centre, Mumbai, Maharashtra, India.; Panda JK; Consultant Physician and Professor, Department of Medicine, Srirama Chandra Bhanja Medical College and Hospital, Cuttack, Odisha, India.; Chakraborty S; Senior Consultant Physician and Director, Department of Medicine, KINS Diabetes Speciality Clinic and KINS Hospital, Siliguri, West Bengal, India.; Ramchandani GD; Physician and Diabetologist, Department of Endocrinology, Diabetes Care and Research Center, Kota, Rajasthan, India.; Chakraborty D; Consultant Physician and Cardiologist, Professor and Head, Department of Medicine, Tripura Medical College, Agartala, Tripura, India.; Datta S; Consultant Physician, Professor and Head, Department of Medicine, Maharaja Jitendra Narayan Medical College and Hospital, Cooch Behar, West Bengal, India, Orcid: https://orcid.org/0000-0001-5221-2054.; Roy MK; Consultant Physician, Department of Medicine, Medical College, Kolkata, West Bengal, India.; Saraf AA; Consultant Physician, Department of Internal Medicine, Jupiter Hospital, Thane, Maharashtra, India.; Das D; Consultant Physician, Professor and Head, Department of Medicine, Tezpur Medical College and Hospital, Tezpur, Assam, India.; Radhakrishnan C; Consultant Physician, Department of Medicine, Government Medical College, Kozhikode, Kerala, India, Orcid: https://orcid.org/0000-0002-0732-0651.; Singh DP; Consultant Physician and Professor, Department of General Medicine, Jawaharlal Nehru Medical College, Bhagalpur, Bihar, India.; Ravikeerthy M; Consultant Physician and Diabetologist, Department of Medicine, V2K Diagnostics and Speciality Clinic, Bengaluru, Karnataka, India.; Mitra S; Senior Vice President, Department of Medical Affairs, Mankind Pharma Limited, Delhi, India, Corresponding Author. |
| Source: | The Journal of the Association of Physicians of India [J Assoc Physicians India] 2025 Aug; Vol. 73 (8), pp. 77-84. |
| Publication Type: | Journal Article; Consensus Statement |
| Language: | English |
| Journal Info: | Publisher: Association of Physicians of India Country of Publication: India NLM ID: 7505585 Publication Model: Print Cited Medium: Print ISSN: 0004-5772 (Print) Linking ISSN: 00045772 NLM ISO Abbreviation: J Assoc Physicians India Subsets: MEDLINE |
| Imprint Name(s): | Publication: Bombay : Association of Physicians of India; Original Publication: Bombay [1953?]- |
| MeSH Terms: | Hypertension*/drug therapy ; Hypertension*/therapy ; Hypertension*/epidemiology ; Hypertension*/complications ; Antihypertensive Agents*/therapeutic use ; Precision Medicine*; Humans ; Consensus ; Phenotype ; Comorbidity ; India |
| Abstract: | Hypertension (HTN) remains a leading contributor to global morbidity and mortality, often coexisting with major comorbidities such as diabetes, chronic kidney disease (CKD), coronary artery disease (CAD), heart failure (HF), and obesity. In India, a significant proportion of hypertensive individuals remain undiagnosed or inadequately treated. This multispecialty consensus provides comprehensive, evidence-based recommendations for individualized HTN management tailored to specific phenotypes and comorbidities. Developed through structured expert panel discussions and a review of international and national guidelines, the consensus emphasizes out-of-office blood pressure (BP) monitoring, phenotype recognition (e.g., white-coat, masked, nocturnal HTN), and early detection of target organ damage. The document outlines practical algorithms and a therapeutic wheel to guide antihypertensive therapy based on patient-specific factors, promoting use of angiotensin-converting enzyme inhibitors (ACEI), angiotensin receptor blockers (ARBs), calcium channel blockers (CCBs), beta-blockers (BB), and diuretics, as per clinical context. Special considerations are provided for managing HTN in young adults, patients with tachycardia, stroke, and respiratory disorders. The consensus also advocates for lifestyle modifications, treatment adherence, and multidisciplinary care to improve BP control and long-term outcomes. By promoting a holistic, patient-centered approach, this consensus aims to bridge gaps in clinical practice and standardize the management of HTN in diverse healthcare settings.; (© Journal of The Association of Physicians of India 2025.) |
| Substance Nomenclature: | 0 (Antihypertensive Agents) |
| Entry Date(s): | Date Created: 20250916 Date Completed: 20250916 Latest Revision: 20260127 |
| Update Code: | 20260130 |
| DOI: | 10.59556/japi.73.1092 |
| PMID: | 40955890 |
| Database: | MEDLINE |
Journal Article; Consensus Statement