Multi-site HPV infection in women with cervical intraepithelial neoplasia: an exploratory analysis.
| Title: | Multi-site HPV infection in women with cervical intraepithelial neoplasia: an exploratory analysis. |
|---|---|
| Authors: | Akçaoğlu T; Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.; Department of Obstetrics and Gynecology, İstanbul Medipol University Faculty of Medicine, İstanbul, Türkiye.; Clinic of Obstetrics and Gynecology, Cengiz Gökçek Gynecology and Pediatrics Hospital, Gaziantep, Türkiye.; Soykan Y; Clinic of Gynecologic Oncology, Cengiz Gökçek Gynecology and Pediatrics Hospital, Gaziantep, Türkiye.; Department of Medical Biology and Genetics, Gazi University Faculty of Medicine, Ankara, Türkiye.; Bayramoğlu Tepe N; Department of Obstetrics and Gynecology, Gaziantep University Faculty of Medicine, Gaziantep, Türkiye.; Doğan O; Department of Obstetrics and Gynecology, İstanbul Nisantaşı University Faculty of Medicine, İstanbul, Türkiye. |
| Source: | Journal of the Turkish German Gynecological Association [J Turk Ger Gynecol Assoc] 2025 Dec 03; Vol. 26 (4), pp. 289-296. Date of Electronic Publication: 2025 Sep 19. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Galenos Publishing House Country of Publication: Turkey NLM ID: 101272522 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1309-0399 (Print) Linking ISSN: 13090380 NLM ISO Abbreviation: J Turk Ger Gynecol Assoc Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Publication: 2017- : Istanbul : Galenos Publishing House; Original Publication: Berlin : Turkish German Gynecological Association |
| Abstract: | Objective: Human papillomavirus (HPV) positivity is associated with cervical, oropharyngeal, and anal cancers. There is insufficient published evidence regarding the effectiveness of obtaining oropharyngeal and anal swabs from patients with cervical HPV positivity to detect potential pathologies. Our aim was to analyze the feasibility of this potential screening protocol in a pilot group.; Material and Methods: In this cross-sectional exploratory analysis, women diagnosed with cervical intraepithelial neoplasia (CIN) grades 1, 2, or 3 were recruited. In order to evaluate HPV infection beyond the cervix, oropharyngeal and anal swab samples from HPV-positive women presenting to the obstetrics and gynecology clinic with histopathologically confirmed CIN were collected.; Results: A total of 30 women who provided informed consent were included in this pilot study. HPV 16 was the predominant cervical HPV type across all CIN grades (46.7% of cases), but HPV genotype did not significantly correlate with the severity of CIN lesions (p=0.786). No statistically significant association was found between cervical and anal HPV infections (p=0.427). Oral HPV positivity was rare (6.7%) and similarly showed no significant correlation with cervical HPV infection (p=0.499).; Conclusion: These findings provide preliminary data on the effectiveness of multi-site HPV screening in this population. Future larger-scale studies are needed to determine whether detecting extra-cervical HPV in women with cervical HPV positivity will influence clinical management decisions.; (Copyright© 2025 The Author. Published by Galenos Publishing House on behalf of Turkish-German Gynecological Association.) |
| Competing Interests: | No conflict of interest is declared by the authors. |
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| Contributed Indexing: | Keywords: Anal; cervical; human papillomavirus; oropharyngeal; screening |
| Entry Date(s): | Date Created: 20250918 Date Completed: 20251203 Latest Revision: 20251206 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC12676993 |
| DOI: | 10.4274/jtgga.galenos.2025.2025-3-10 |
| PMID: | 40965375 |
| Database: | MEDLINE |
Journal Article