Neuropsychomotor Development of Children Exposed to SARS-CoV-2 in Utero During COVID-19 Pandemic.
| Title: | Neuropsychomotor Development of Children Exposed to SARS-CoV-2 in Utero During COVID-19 Pandemic. |
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| Authors: | Motta F; Programa de Pós-Graduação em Ciências Médicas, Universidade de Brasília (UnB), Brasília 70910-900, Distrito Federal, Brazil.; Canellas-de-Castro ME; Programa de Pós-Graduação em Ciências Médicas, Universidade de Brasília (UnB), Brasília 70910-900, Distrito Federal, Brazil.; Hospital Universitário de Brasília, Universidade de Brasília (UnB), Brasília 70830-200, Distrito Federal, Brazil.; Fernandes GM; Programa de Pós-Graduação em Ciências Médicas, Universidade de Brasília (UnB), Brasília 70910-900, Distrito Federal, Brazil.; Sasaki LMP; Programa de Pós-Graduação em Ciências Médicas, Universidade de Brasília (UnB), Brasília 70910-900, Distrito Federal, Brazil.; Hospital Universitário de Brasília, Universidade de Brasília (UnB), Brasília 70830-200, Distrito Federal, Brazil.; de Araújo Júnior DA; Programa de Pós-Graduação em Ciências Médicas, Universidade de Brasília (UnB), Brasília 70910-900, Distrito Federal, Brazil.; Zaconeta AM; Faculdade de Medicina, Universidade de Brasilia (UnB), Brasília 70910-900, Distrito Federal, Brazil.; da Silva ÂP; Hospital Universitário de Brasília, Universidade de Brasília (UnB), Brasília 70830-200, Distrito Federal, Brazil.; Gomes CM; Programa de Pós-Graduação em Ciências Médicas, Universidade de Brasília (UnB), Brasília 70910-900, Distrito Federal, Brazil.; Faculdade de Medicina, Universidade de Brasilia (UnB), Brasília 70910-900, Distrito Federal, Brazil.; Programa de Pós-Graduação em Patologia Molecular, Universidade de Brasilia (UnB), Brasília 70910-900, Distrito Federal, Brazil.; Albuquerque CP; Programa de Pós-Graduação em Ciências Médicas, Universidade de Brasília (UnB), Brasília 70910-900, Distrito Federal, Brazil.; Hospital Universitário de Brasília, Universidade de Brasília (UnB), Brasília 70830-200, Distrito Federal, Brazil.; Costa-Rocha IA; Instituto René Rachou, Fundação Oswaldo Cruz (FIOCRUZ-Minas), Belo Horizonte 30190-002, Minas Gerais, Brazil.; Santos JAT; Secretaria de Saúde do Distrito Federal, Brasília 70719-040, Distrito Federal, Brazil.; Jesus JAL; Faculdade de Medicina, Universidade de Brasilia (UnB), Brasília 70910-900, Distrito Federal, Brazil.; Costa KN; Faculdade de Medicina, Universidade de Brasilia (UnB), Brasília 70910-900, Distrito Federal, Brazil.; Espindola LS; Programa de Pós-Graduação em Ciências Médicas, Universidade de Brasília (UnB), Brasília 70910-900, Distrito Federal, Brazil.; Mota LMHD; Programa de Pós-Graduação em Ciências Médicas, Universidade de Brasília (UnB), Brasília 70910-900, Distrito Federal, Brazil.; Hospital Universitário de Brasília, Universidade de Brasília (UnB), Brasília 70830-200, Distrito Federal, Brazil.; Programa de Pós-Graduação em Patologia Molecular, Universidade de Brasilia (UnB), Brasília 70910-900, Distrito Federal, Brazil.; Lauand L; Faculdade de Medicina, Universidade de Brasilia (UnB), Brasília 70910-900, Distrito Federal, Brazil.; Castro LCG; Programa de Pós-Graduação em Ciências Médicas, Universidade de Brasília (UnB), Brasília 70910-900, Distrito Federal, Brazil.; Faculdade de Medicina, Universidade de Brasilia (UnB), Brasília 70910-900, Distrito Federal, Brazil.; Xavier MAP; Instituto René Rachou, Fundação Oswaldo Cruz (FIOCRUZ-Minas), Belo Horizonte 30190-002, Minas Gerais, Brazil.; Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte 30130-100, Minas Gerais, Brazil.; Coelho-Dos-Reis JGA; Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte 30130-100, Minas Gerais, Brazil.; Nóbrega OT; Programa de Pós-Graduação em Ciências Médicas, Universidade de Brasília (UnB), Brasília 70910-900, Distrito Federal, Brazil.; Silva PCD; Faculdade de Terapia Ocupacional, Universidade de Brasilia (UnB), Ceilândia 72220-275, Distrito Federal, Brazil.; Nery RR; Faculdade de Medicina, Universidade de Brasilia (UnB), Brasília 70910-900, Distrito Federal, Brazil.; Santos WT; Faculdade de Terapia Ocupacional, Universidade de Brasilia (UnB), Ceilândia 72220-275, Distrito Federal, Brazil.; Tristão RM; Faculdade de Medicina, Universidade de Brasilia (UnB), Brasília 70910-900, Distrito Federal, Brazil.; Alves CO; Faculdade de Terapia Ocupacional, Universidade de Brasilia (UnB), Ceilândia 72220-275, Distrito Federal, Brazil.; Martins-Filho OA; Instituto René Rachou, Fundação Oswaldo Cruz (FIOCRUZ-Minas), Belo Horizonte 30190-002, Minas Gerais, Brazil.; Soares AASM; Programa de Pós-Graduação em Ciências Médicas, Universidade de Brasília (UnB), Brasília 70910-900, Distrito Federal, Brazil. |
| Corporate Authors: | PROUDEST Study—Pregnancy Outcomes and Child Development Effects of SARS-CoV-2 Infection |
| Source: | Biomedicines [Biomedicines] 2025 Sep 12; Vol. 13 (9). Date of Electronic Publication: 2025 Sep 12. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101691304 Publication Model: Electronic Cited Medium: Print ISSN: 2227-9059 (Print) Linking ISSN: 22279059 NLM ISO Abbreviation: Biomedicines Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: Basel, Switzerland : MDPI AG, [2013]- |
| Abstract: | Introduction: Little is known about the effects of intrauterine exposure to SARS-CoV-2, especially on growth and neurodevelopment in children. Objective: We wished to verify the effect of intrauterine exposure to SARS-CoV-2 on neurological development in children. Methods: Infants born to mothers presenting with SARS-CoV-2 infection during pregnancy were enrolled in a prospective descriptive-analytical study involving outpatient appointments performed 6 and 12 months after birth. Their neurological development was assessed using the Bayley-III Scale, using a score of >85 as the cutoff threshold for identifying developmental delay. Differences between groups were assessed through an ANOVA, using Bonferroni correction for multiple comparisons. Regression models were employed to examine the associations between the Bayley-III scores and maternal features. Results: Two hundred and sixty-nine infants were evaluated, most of whom were born full-term and with birth weights appropriate for gestational age at delivery. Developmental delays were observed in 26% of the infants in at least one of the Bayley-III domains. The language domain was particularly affected, with impairments observed in children exposed to SARS-CoV-2 closer to the time of delivery. These findings were statistically significant (p < 0.05). Conclusions: Infants born to mothers presenting with SARS-CoV-2 infection during pregnancy presented developmental delays at 6 and 12 months, particularly in the language domain. These findings reinforce the relevance of long-term clinical follow-ups of newborns exposed to SARS-CoV-2 infection during pregnancy. |
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| Contributed Indexing: | Keywords: COVID-19; SARS-CoV-2; child development; infants; neonatal disease; neuropsychological tests; pandemic |
| Entry Date(s): | Date Created: 20250927 Date Completed: 20250927 Latest Revision: 20250930 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC12467609 |
| DOI: | 10.3390/biomedicines13092256 |
| PMID: | 41007817 |
| Database: | MEDLINE |
Journal Article