Pathological Characteristics of the Emerging Recombinant African Swine Fever Virus Genotypes I and II in Vietnam.
| Title: | Pathological Characteristics of the Emerging Recombinant African Swine Fever Virus Genotypes I and II in Vietnam. |
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| Authors: | Nguyen VD; Department of Microbiology and Infectious Disease, College of Veterinary Medicine, Vietnam National University of Agriculture, Hanoi 100000, Vietnam.; Faculty of Animal Science and Veterinary Medicine, Bac Giang Agriculture and Forestry University, Bac Giang 230000, Vietnam.; Nguyen TVH; Department of Microbiology and Infectious Disease, College of Veterinary Medicine, Vietnam National University of Agriculture, Hanoi 100000, Vietnam.; Laboratory of Viral Infectious Diseases, Center for Research Excellence and Innovation, Vietnam National University of Agriculture, Hanoi 100000, Vietnam.; Vu ND; Laboratory of Viral Infectious Diseases, Center for Research Excellence and Innovation, Vietnam National University of Agriculture, Hanoi 100000, Vietnam.; Than TT; Laboratory of Viral Infectious Diseases, Center for Research Excellence and Innovation, Vietnam National University of Agriculture, Hanoi 100000, Vietnam.; Tran TCG; Laboratory of Viral Infectious Diseases, Center for Research Excellence and Innovation, Vietnam National University of Agriculture, Hanoi 100000, Vietnam.; Vu TTH; Institute of Veterinary Science and Technology, Vietnam Union of Science and Technology Association, Hanoi 100000, Vietnam.; Nguyen TL; Department of Microbiology and Infectious Disease, College of Veterinary Medicine, Vietnam National University of Agriculture, Hanoi 100000, Vietnam.; Kim YH; Foreign Animal Disease Division, Animal and Plant Quarantine Agency, Gimcheon 39660, Republic of Korea.; Ambagala A; Canadian Food Inspection Agency, National Centre for Foreign Animal Disease, Winnipeg, MB R3E 3R2, Canada.; Department of Medical Microbiology and Infectious Diseases, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.; Le VP; Department of Microbiology and Infectious Disease, College of Veterinary Medicine, Vietnam National University of Agriculture, Hanoi 100000, Vietnam.; Laboratory of Viral Infectious Diseases, Center for Research Excellence and Innovation, Vietnam National University of Agriculture, Hanoi 100000, Vietnam. |
| Source: | Pathogens (Basel, Switzerland) [Pathogens] 2025 Sep 02; Vol. 14 (9). Date of Electronic Publication: 2025 Sep 02. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101596317 Publication Model: Electronic Cited Medium: Internet ISSN: 2076-0817 (Electronic) Linking ISSN: 20760817 NLM ISO Abbreviation: Pathogens Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Basel, Switzerland : MDPI AG, 2012- |
| MeSH Terms: | African Swine Fever*/virology ; African Swine Fever*/pathology ; African Swine Fever Virus*/genetics ; African Swine Fever Virus*/pathogenicity ; Genotype* ; Recombination, Genetic*; Vietnam/epidemiology ; Animals ; Swine ; Virulence |
| Abstract: | African swine fever (ASF) is a highly lethal disease caused by the ASF virus (ASFV) and poses a significant threat to the swine industry worldwide. This study investigated the pathogenicity and pathological characteristics of VNUA/rASFV/HD1/23, a recently identified recombinant ASFV genotype I/II in northern Vietnam. Sixteen healthy, seven-week-old pigs divided into four groups were inoculated intramuscularly (IM) with different virus concentrations (102, 103, and 104 HAD50/mL), and their clinical signs, survival times, and pathological alterations were evaluated. All experimentally infected pigs exhibited acute clinical signs characterized by fever, anorexia, depression, diarrhea, and death (4-10 days after injection). The pathological findings included splenomegaly with infarcts, hemorrhagic lymph nodes, and severe pulmonary congestion. The pigs that received the highest dose (104 HAD50/mL) IM showed the earliest onset of clinical signs and the shortest survival time. This study provides important insights into the virulence and the pathological lesions induced by the recombinant genotype I/II ASFV strains that emerged in Vietnam. |
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| Grant Information: | # 20-015. US Swine Health Information Center (SHIC) Grant |
| Contributed Indexing: | Keywords: ASFV; clinical signs; pathology; recombinant ASFV genotype I/II strain |
| Entry Date(s): | Date Created: 20250927 Date Completed: 20250927 Latest Revision: 20250930 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC12473001 |
| DOI: | 10.3390/pathogens14090875 |
| PMID: | 41011775 |
| Database: | MEDLINE |
Journal Article