Modulation of gene expression by traditional Asian antidiabetic nutraceuticals: A review of potential effects.
| Title: | Modulation of gene expression by traditional Asian antidiabetic nutraceuticals: A review of potential effects. |
|---|---|
| Authors: | Roosita K; Department of Community Nutrition, Faculty of Human Ecology, IPB University, Bogor, Indonesia. Email: kroosita2@apps.ipb.ac.id.; Ekawidyani KR; Department of Community Nutrition, Faculty of Human Ecology, IPB University, Bogor, Indonesia. Email: karinare@apps.ipb.ac.id.; Kushargina R; Nutrition Study Program, Faculty of Medicine and Health, Universitas Muhammadiyah Jakarta, Jakarta, Indonesia.; Fathimah; Doctoral Study Program in Nutrition Sciences, Department of Community Nutrition, Faculty of Human Ecology, IPB University, Bogor, Indonesia.; Nutritional Science Study Program, Faculty of Health Sciences, Universitas Darussalam Gontor, Ponorogo, East Java, Indonesia.; Rafi M; Department of Chemistry, Faculty of Mathematics and Natural Science, IPB University, Bogor, Indonesia.; Saepuloh U; Primate Research Center IPB University, Bogor, Indonesia. |
| Source: | Asia Pacific journal of clinical nutrition [Asia Pac J Clin Nutr] 2025 Oct; Vol. 34 (5), pp. 759-782. |
| Publication Type: | Journal Article; Review |
| Language: | English |
| Journal Info: | Publisher: Qingdao University Country of Publication: China NLM ID: 9440304 Publication Model: Print Cited Medium: Internet ISSN: 1440-6047 (Electronic) Linking ISSN: 09647058 NLM ISO Abbreviation: Asia Pac J Clin Nutr Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2023- : Qingdao : Qingdao University; Original Publication: London, UK : Published for the Asia Pacific Clinical Nutrition Society by Smith-Gordon |
| MeSH Terms: | Diabetes Mellitus, Type 2*/genetics ; Diabetes Mellitus, Type 2*/drug therapy ; Hypoglycemic Agents*/pharmacology ; Gene Expression*/drug effects ; Dietary Supplements*; Antioxidants/pharmacology ; Humans ; Animals |
| Abstract: | Background and Objectives: Type 2 diabetes mellitus (T2DM) has emerged as a significant global public health concern. Multiple studies have shown that traditional nutraceuticals are potential to treat T2DM and its complications. This review will explore traditional nutraceuticals with antidiabetic properties with a focus on traditional Asian nutraceuticals and their antioxidant effects on gene expression associated to T2DM.; Methods and Study Design: Literature searching was conducted in Pubmed, Scopus, and Science Direct using the keywords "nutraceutical", "antidiabetic", "insulin resistance", "Diabetes Mellitus", "herbal medicine", "mechanism", "pathway", "traditional food", "functional food", "antioxidant", "clinical", "preclinical", "animal studies", and "Asian" combined with Boolean operators "OR".; Results: Nutraceuticals sourced from traditional Indonesian herbal beverages, including Galohgor, Bir Pletok, and Wedang Uwuh, have shown potential efficacy in reducing hyperglycemia, oxidative stress, and obesity in T2DM. Furthermore, multiple Asian plants and their bioactive compounds, such as curcumin, kaempferol, cinnamon, saponin, quercetin, myricetin, anthocyanin, terpenoid, alkaloid, and gallic acid, have been shown to beneficially influence glucose ho-meostasis, insulin sensitivity, and problems associated with diabetes. Moreover, bioactive compounds of these traditional nutraceuticals have been proven in modulating gene expression associated with β-cell function, insulin signaling pathway, and antioxidant activity, which may offer a new therapeutic target.; Conclusions: This review highlights the increasing scientific evidence on the role of traditional nutraceuticals for the prevention and management of diabetes mellitus, presenting promising alternatives to standard pharmacologi-cal therapy. Nonetheless, double-blind randomized clinical trials are required to validate these antidiabetic effects. |
| Competing Interests: | The authors declare no conflict of interest |
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| Grant Information: | 22049/IT3.D10/PT.01.03/P/B/2024 Ministry of Education, Culture, Research, and Technology, Republic of Indonesia |
| Contributed Indexing: | Keywords: Asian traditional nutraceutical; antioxidants; gene expression; oxidative stress; type 2 diabetes mellitus |
| Substance Nomenclature: | 0 (Hypoglycemic Agents); 0 (Antioxidants) |
| Entry Date(s): | Date Created: 20251002 Date Completed: 20251002 Latest Revision: 20251007 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC12490953 |
| DOI: | 10.6133/apjcn.202510_34(5).0006 |
| PMID: | 41038680 |
| Database: | MEDLINE |
Journal Article; Review