Oxidative stress in malaria and typhoid fever: A scoping review of the pathogenic mechanisms and therapeutic implications.
| Title: | Oxidative stress in malaria and typhoid fever: A scoping review of the pathogenic mechanisms and therapeutic implications. |
|---|---|
| Authors: | Netongo PM; Department of Biochemistry, University of Yaoundé 1, Yaoundé, Cameroon.; Molecular Diagnostics Research Group, Biotechnology Centre, University of Yaoundé 1, Yaoundé, Cameroon.; Laboratory for Public Health Research Biotechnologies, Biotechnology Centre, University of Yaoundé 1, Yaoundé, Cameroon.; School of Science, Navajo Technical University, Crownpoint, New Mexico, United States of America.; Eric MB; Department of Biochemistry, University of Yaoundé 1, Yaoundé, Cameroon.; Molecular Diagnostics Research Group, Biotechnology Centre, University of Yaoundé 1, Yaoundé, Cameroon.; Laboratory for Public Health Research Biotechnologies, Biotechnology Centre, University of Yaoundé 1, Yaoundé, Cameroon.; Kamdem SD; Molecular Diagnostics Research Group, Biotechnology Centre, University of Yaoundé 1, Yaoundé, Cameroon.; Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.; School of Health Sciences, Catholic University of Central Africa, Yaoundé, Cameroon.; Tchoutang AM; Department of Biochemistry, University of Yaoundé 1, Yaoundé, Cameroon.; Molecular Diagnostics Research Group, Biotechnology Centre, University of Yaoundé 1, Yaoundé, Cameroon.; Mbacham WF; Department of Biochemistry, University of Yaoundé 1, Yaoundé, Cameroon.; Laboratory for Public Health Research Biotechnologies, Biotechnology Centre, University of Yaoundé 1, Yaoundé, Cameroon. |
| Source: | PLOS global public health [PLOS Glob Public Health] 2025 Oct 09; Vol. 5 (10), pp. e0005193. Date of Electronic Publication: 2025 Oct 09 (Print Publication: 2025). |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Public Library of Science Country of Publication: United States NLM ID: 9918283779606676 Publication Model: eCollection Cited Medium: Internet ISSN: 2767-3375 (Electronic) Linking ISSN: 27673375 NLM ISO Abbreviation: PLOS Glob Public Health Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: San Francisco, California : Public Library of Science, [2021]- |
| Abstract: | Oxidative stress is a key factor in the pathogenesis of many infectious diseases, including typhoid fever and malaria. Co-infection with these diseases poses a particular challenge, as both are associated with increased production of reactive species that can damage tissues, trigger oxidative stress, and exacerbate disease. To cope with this oxidative insult, cells have a defense system consisting of antioxidant molecules that can terminate the oxygen radical cascade and render toxic metabolites innocuous. However, lack of complete understanding of the pathophysiology of malaria and typhoid fever continues to hinder efforts aimed at eradicating these diseases. In this review, we examine the current understanding of oxidative stress in the context of malaria and typhoid fever, and its implications for disease pathogenesis and treatment. The search and data extraction strategy used in this scoping review involved a structured approach to identify relevant studies related to the topic. Studies were included that investigated ROS production, antioxidant responses, and the effect of pharmacological interventions on oxidative stress markers. The search was conducted using electronic databases, including PubMed, ScienceDirect, and Directory of Open Access Journals (DOAJ), and involved an extensive literature search of studies published between January 2000 and May 2024. The review identified potential avenues for research with evidence that both malaria and typhoid fever elevate oxidative stress levels, which are further exacerbated in co-infections. The endogenous antioxidant response is activated but may not be sufficient to neutralize ROS completely. Moreover, commonly used antimalarial and antibacterial drugs influence oxidative and antioxidant dynamics, which may have implications for treatment efficacy and disease progression. Understanding the oxidative-antioxidant balance in malaria and/or typhoid fever may open new avenues for adjunctive therapies and vaccines targeting oxidative stress. It is thus important to consider the oxidative-antioxidant balance during treatment of malaria and typhoid fever patients.; (Copyright: © 2025 Netongo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.) |
| Competing Interests: | The authors have declared that no competing interests exist. |
| References: | Parasitol Res. 2021 Feb;120(2):423-434. (PMID: 33459846); Redox Rep. 2003;8(5):292-4. (PMID: 14962368); Front Cell Infect Microbiol. 2021 Nov 30;11:768182. (PMID: 34917519); Philos Trans R Soc Lond B Biol Sci. 2010 Mar 12;365(1541):749-63. (PMID: 20124342); Int J Mol Sci. 2020 Dec 18;21(24):. (PMID: 33353225); J Exp Med. 2002 May 6;195(9):1155-66. (PMID: 11994420); Int J Mol Sci. 2020 Jul 06;21(13):. (PMID: 32640524); J Trop Pediatr. 2012 Apr;58(2):147-50. (PMID: 21602230); Pak J Biol Sci. 2013 Feb 15;16(4):160-7. (PMID: 24171263); Arch Microbiol. 2022 Jul 13;204(8):479. (PMID: 35831726); PLoS One. 2015 May 26;10(5):e0128212. (PMID: 26010448); Malar J. 2004 Jul 09;3:23. (PMID: 15245577); Mol Microbiol. 2004 Sep;53(5):1291-305. (PMID: 15387810); Indian J Physiol Pharmacol. 2009 Jul-Sep;53(3):271-4. (PMID: 20329375); Biol Chem. 2017 Sep 26;398(10):1095-1108. (PMID: 28384098); Sci Rep. 2016 Apr 18;6:24461. (PMID: 27087557); J Bacteriol. 2000 Jan;182(1):23-9. (PMID: 10613858); J Trop Med. 2020 Aug 11;2020:7209542. (PMID: 32849882); An Acad Bras Cienc. 2015 Aug;87(2 Suppl):1487-96. (PMID: 26312430); Biochem Pharmacol. 2023 Dec;218:115927. (PMID: 37992998); Immunol Lett. 2017 Oct;190:42-50. (PMID: 28720334); Antioxidants (Basel). 2021 Nov 24;10(12):. (PMID: 34942976); Front Cell Infect Microbiol. 2022 Aug 25;12:986314. (PMID: 36093191); Behav Sci (Basel). 2022 Aug 14;12(8):. (PMID: 36004858); Adv Med. 2014;2014:531074. (PMID: 26556415); In Vivo. 2002 Jan-Feb;16(1):67-70. (PMID: 11980364); Front Immunol. 2014 Feb 05;5:25. (PMID: 24550911); Front Genet. 2022 Jan 10;12:821535. (PMID: 35082839); Front Cell Infect Microbiol. 2020 Nov 24;10:572912. (PMID: 33330122); J Innate Immun. 2019;11(3):216-226. (PMID: 30943492); Chem Biol. 2002 Mar;9(3):321-32. (PMID: 11927257); Redox Rep. 2003;8(5):251-5. (PMID: 14962359); Int J Parasitol. 2004 Feb;34(2):163-89. (PMID: 15037104); Biochem Biophys Res Commun. 2017 Jun 17;488(1):95-100. (PMID: 28479253); Eur J Clin Microbiol Infect Dis. 2024 May;43(5):915-926. (PMID: 38472520); Antioxid Redox Signal. 2013 Nov 1;19(13):1539-605. (PMID: 23397885); Parasitology. 2008 Jun;135(7):749. (PMID: 18578954); Biochem Pharmacol. 2018 Jul;153:159-167. (PMID: 29452096); J Infect Dev Ctries. 2008 Aug 30;2(4):260-6. (PMID: 19741286); J Trop Med. 2019 Jul 07;2019:8479076. (PMID: 31360173); Int J Mol Sci. 2012 Dec 03;13(12):16346-72. (PMID: 23208374); Shock. 2018 Dec;50(6):741-749. (PMID: 29394238); Naunyn Schmiedebergs Arch Pharmacol. 2023 Oct;396(10):2667-2686. (PMID: 37083711); Redox Rep. 2003;8(5):231-3. (PMID: 14962354); Oxid Med Cell Longev. 2020 Jul 23;2020:2082145. (PMID: 32774665); J Antimicrob Chemother. 2014 Apr;69(4):1005-16. (PMID: 24335485); Blood. 2013 Feb 21;121(8):1276-84. (PMID: 23264591); Mol Cell Proteomics. 2011 Aug;10(8):M110.006411. (PMID: 21558492); FEBS J. 2017 Aug;284(16):2579-2591. (PMID: 28467668); Antioxidants (Basel). 2023 Jun 30;12(7):. (PMID: 37507911); Infect Immun. 2005 Oct;73(10):6704-10. (PMID: 16177347); Int J Mol Sci. 2022 May 25;23(11):. (PMID: 35682626); Parasit Vectors. 2017 Oct 10;10(1):461. (PMID: 29017543); Int J Med Mushrooms. 2014;16(5):499-506. (PMID: 25271985); J Integr Med. 2019 Nov;17(6):438-445. (PMID: 31611062); J Biol Chem. 2011 Apr 1;286(13):11746-55. (PMID: 21282103); Front Pharmacol. 2019 Jul 24;10:825. (PMID: 31396090); Free Radic Biol Med. 2004 May 15;36(10):1199-207. (PMID: 15110384) |
| Entry Date(s): | Date Created: 20251009 Date Completed: 20251009 Latest Revision: 20251012 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC12510597 |
| DOI: | 10.1371/journal.pgph.0005193 |
| PMID: | 41066333 |
| Database: | MEDLINE |
Journal Article