Autophagy regulation by signaling.
| Title: | Autophagy regulation by signaling. |
|---|---|
| Authors: | Rusten TE; Center for Cancer Cell Reprogramming, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway; Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway. Electronic address: t.e.rusten@medisin.uio.no. |
| Source: | Current opinion in cell biology [Curr Opin Cell Biol] 2025 Dec; Vol. 97, pp. 102595. Date of Electronic Publication: 2025 Oct 13. |
| Publication Type: | Journal Article; Review |
| Language: | English |
| Journal Info: | Publisher: Elsevier Country of Publication: England NLM ID: 8913428 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0410 (Electronic) Linking ISSN: 09550674 NLM ISO Abbreviation: Curr Opin Cell Biol Subsets: MEDLINE |
| Imprint Name(s): | Publication: London : Elsevier; Original Publication: Philadelphia, PA, USA : Current Science, c1988- |
| MeSH Terms: | Autophagy* ; Signal Transduction*; Humans ; Animals ; Mechanistic Target of Rapamycin Complex 1 |
| Abstract: | The first identified regulators of autophagy were the hormones Glucagon and Insulin, long before the recognition that they act through receptor-mediated cell signaling pathways. More than two decades since the identification of the autophagy molecular machinery, we appreciate that regulation of autophagy is complex, operates at several levels, and serves many functions to maintain cellular and organismal health. TORC1 remains the best-defined gatekeeper, serving to sense nutrient and energy sufficiency while also integrating systemic growth factor signaling to control cell growth and autophagy autonomously. This review summarizes the current understanding of autophagy regulation by signaling through TORC1-dependent and independent mechanisms and discusses the emerging understanding of control and coordinated response of autophagy at the organism level.; (Copyright © 2025 The Author. Published by Elsevier Ltd.. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Substance Nomenclature: | EC 2.7.11.1 (Mechanistic Target of Rapamycin Complex 1) |
| Entry Date(s): | Date Created: 20251014 Date Completed: 20251210 Latest Revision: 20251210 |
| Update Code: | 20260130 |
| DOI: | 10.1016/j.ceb.2025.102595 |
| PMID: | 41086756 |
| Database: | MEDLINE |
Journal Article; Review