EndoCompass project: research roadmap for diabetes, obesity, and metabolism.
| Title: | EndoCompass project: research roadmap for diabetes, obesity, and metabolism. |
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| Authors: | Mathieu C; Department of Endocrinology, UZ Gasthuisberg, Katholieke Universiteit Leuven, 3000 Leuven, Belgium.; Meireles M; European Association for the Study of Diabetes, 40591 Düsseldorf, Germany.; Pagotto U; Division of Endocrionology and Diabetes Prevention and Care, IRCCS Azienda Ospedaliero-Universtaria di Bologna; Department of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna, 40138 Bologna, Italy.; Wabitsch M; Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, 89075 Ulm, Germany.; Banerjee I; Pediatric Endocrinology, Manchester University NHS Foundation Trust, M13 9 WL, Manchester, United Kingdom.; Bartolomé A; Instituto de Investigaciones Biomédicas Sols-Morreale (CSIC/UAM), 28029 Madrid, Spain.; CIBER de Diabetes y Enfermedades Metabólicas Asociadas, 28029 Madrid, Spain.; Battelino T; Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia.; Department of Endocrinology, Diabetes and Metabolic Diseases, University Children's Hospital, UMC, University Medical Centre Ljubljana, 1000 Ljubljana, Slovenia.; Beck J; Department of Endocrinology, Diabetes and Metabolism, University Hospital Basel, 4031 Basel, BS, Switzerland.; Chiarelli F; Department of Paediatrics, University of Chieti, 66100 Chieti, Italy.; De Leon DD; Congenital Hyperinsulinism Center, Division of Endocrinology and Diabetes, Children's Hospital of Philadelphia, University of Pennsylvania, 19104 Philadelphia, Pennsylvania, United States.; Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, 19104 Philadelphia, Pennsylvania, United States.; Dovč K; Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia.; Department of Endocrinology, Diabetes and Metabolic Diseases, University Children's Hospital, UMC, University Medical Centre Ljubljana, 1000 Ljubljana, Slovenia.; El Ghoch M; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Italy.; Galderisi A; Department of Pediatrics, Yale University, 06510 New Haven, Connecticut, United States.; Gevers E; Centre for Endocrinology, William Harvey Research Institute, Queen Mary University of London, E1 4NS London, United Kingdom.; Gillard P; Department of Endocrinology, University Hospitals Leuven, 3000 Leuven, Belgium.; Haliloglu B; Department of Pediatric Endocrinology and Diabetology, Marmara University Faculty of Medicine, 34722 İstanbul, Turkey.; Hoermann H; Department of General Paediatrics, Neonatology and Paediatric Cardiology, University Children's Hospital Düsseldorf, 40225 Düsseldorf, Germany.; Mankovsky B; Institute of Gerontology, Kyiv, 04114, Ukraine.; Mertens J; Laboratory of Experimental Medicine and Paediatrics, Universiteit Antwerpen, 2000 Antwerp, Flanders, Belgium.; Department of Endocrinology, Diabetology and Metabolism, Antwerp University Hospital, 2650 Edegem, Belgium.; Mohnike K; Department of Pediatrics, Otto von Guericke Universitat Magdeburg, 39016 Magdeburg, Sachsen-Anhalt, Germany.; Oram R; Institute of Biomedical and Clinical Science, University of Exeter Medical School, EX4 4QJ Exeter, United Kingdom.; Pasquini T; Congenital Hyperinsulinism International, 07028 Glen Ridge, NJ, United States.; Pearson E; Diabetes and Endocrinology, Ninewells Hospital, DD1 9SY Dundee, United Kingdom.; Pieber TR; Internal Medicine, Medical University of Graz, 8010 Graz, Austria.; Polovina S; Clinic for Endocrinology, Diabetes, and Metabolic Diseases, University Clinical Center of Serbia, 11000 Belgrade, Serbia.; Raskin J; Congenital Hyperinsulinism International, 07028 Glen Ridge, NJ, United States.; Roeper M; Department of General Paediatrics, Neonatology and Paediatric Cardiology, University Children's Hospital Düsseldorf, 40225 Düsseldorf, Germany.; Department for paediatric endocrinology and diabetology, Charité Universitätsmedizin Berlin, 10117 Berlin, Germany.; Ruck L; Department for paediatric endocrinology and diabetology, Charité Universitätsmedizin Berlin, 10117 Berlin, Germany.; Salomon Estebanez M; Department of Paediatric Endocrinology, Royal Manchester Children's Hospital, M13 9WL Manchester, United Kingdom.; Tankova T; Department of Endocrinology, Medical University - Sofia,1431 Sofia, Bulgaria.; Thornton P; Pediatric Endocrinology, Cook Children's Medical Center, Fort Worth, TX 76104, United States.; van Rossum EFC; Department of Internal Medicine, Division of Endocrinology, Obesity Center CGG, Erasmus MC, 3000 CA Rotterdam, Netherlands.; Vukovic R; Medical Faculty, University of Belgrade, 10117 Belgrade, Serbia.; Department of Endocrinology, Mother and Child Health Care Institute of Serbia 'Dr dr Vukan Čupić', 11070 Belgrade, Serbia.; Worth C; Department of Paediatric Endocrinology, Royal Manchester Children's Hospital, M13 9WL Manchester, United Kingdom.; Zachurzok A; Department of Pediatrics, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 41-800 Zabrze, Poland. |
| Source: | European journal of endocrinology [Eur J Endocrinol] 2025 Oct 17; Vol. 193 (Supplement_2), pp. ii47-ii71. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Oxford University Press Country of Publication: England NLM ID: 9423848 Publication Model: Print Cited Medium: Internet ISSN: 1479-683X (Electronic) Linking ISSN: 08044643 NLM ISO Abbreviation: Eur J Endocrinol Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2023- : Oxford : Oxford University Press; Original Publication: Oslo, Norway : Scandinavian University Press, c1994- |
| MeSH Terms: | Obesity*/therapy ; Obesity*/metabolism ; Obesity*/epidemiology ; Biomedical Research*/trends ; Diabetes Mellitus*/therapy ; Metabolic Diseases*/therapy ; Endocrinology*; Humans ; European Union |
| Abstract: | Background: Endocrine science remains underrepresented in European Union research programmes despite the fundamental role of hormone health in human well-being. Analysis of the CORDIS database reveals a persistent gap between the societal impact of endocrine disorders and their research prioritization. At national funding level, endocrine societies report limited or little attention of national research funding towards endocrinology. The EndoCompass project-a joint initiative between the European Society of Endocrinology and the European Society of Paediatric Endocrinology, aimed to identify and promote strategic research priorities in endocrine science to address critical hormone-related health challenges.; Methods: Research priorities were established through comprehensive analysis of the EU CORDIS database covering the Horizon 2020 framework period (2014-2020). Expert consultation was conducted to identify key research priorities, followed by broader stakeholder engagement including society members and patient advocacy groups.; Results: Research priorities include: genetic/epigenetic factors, brain-periphery communication, and environmental influences. Key therapeutic areas include innovative approaches for monogenic disorders, incretin mimetics, dual receptor agonists, microbiome analysis, and improved behavioural interventions. For type 1 diabetes, priorities focus on early detection, insulin delivery systems, and disease-modifying therapies.; Conclusions: This component of the EndoCompass project provides an evidence-based roadmap for strategic research investment. This framework identifies crucial investigation areas into diabetes and obesity pathophysiology, prevention, and treatment strategies, ultimately aimed at reducing the burden of metabolic disorders on individuals and society. The findings support the broader EndoCompass objective of aligning research funding with areas of highest potential impact in endocrine health.; (© The Author(s) 2025. Published by Oxford University Press on behalf of European Society of Endocrinology.) |
| Competing Interests: | Conflict of interest: none declared. |
| Contributed Indexing: | Keywords: EndoCompass; diabetes; funding; obesity; roadmap |
| Entry Date(s): | Date Created: 20251017 Date Completed: 20251017 Latest Revision: 20251017 |
| Update Code: | 20260130 |
| DOI: | 10.1093/ejendo/lvaf065 |
| PMID: | 41104472 |
| Database: | MEDLINE |
Journal Article