Antimicrobial efficacy of pineapple extract Bromelain against Enterococcus faecalis in infected root canals: A systematic review.
| Title: | Antimicrobial efficacy of pineapple extract Bromelain against Enterococcus faecalis in infected root canals: A systematic review. |
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| Authors: | Chandwani ND; Department of Dentistry, All India Institute of Medical Sciences, Nagpur, India.; Gandhi AP; Department of Community Medicine, All India Institute of Medical Sciences, Nagpur, India.; Deshmukh R; Department of Dentistry, All India Institute of Medical Sciences, Nagpur, India.; Gayake A; Department of Dentistry, All India Institute of Medical Sciences, Nagpur, India.; Deshmukh K; Department of Community Medicine, All India Institute of Medical Sciences, Nagpur, India.; Chhabra A; Department of Dentistry, All India Institute of Medical Sciences, Kalyani, West Bengal, India. |
| Source: | Journal of conservative dentistry and endodontics [J Conserv Dent Endod] 2025 Oct; Vol. 28 (10), pp. 957-964. Date of Electronic Publication: 2025 Oct 04. |
| Publication Type: | Journal Article; Review |
| Language: | English |
| Journal Info: | Publisher: Wolters Kluwer - Medknow Country of Publication: India NLM ID: 9918697474706676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2950-4708 (Electronic) Linking ISSN: 29504708 NLM ISO Abbreviation: J Conserv Dent Endod Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: [Mumbai] : Wolters Kluwer - Medknow, [2023]- |
| Abstract: | Background: Enterococcus faecalis, an anaerobic Gram-positive coccus, is commonly associated with failed endodontic treatment. E. faecalis is resistant to conventional antibiotic therapy. Yet other materials like bromelain are investigated for its activity against E. faecalis.; Aim: To review the literature and compile them to comprehensively enumerate and present the antimicrobial efficacy of pineapple extract bromelain against E. faecaliss.; Materials and Methods: To find articles published up until August 31, 2024, a literature search was conducted. The papers were examined independently by two reviewers.; Results: Out of the five studies selected based on the inclusion and exclusion criteria, four studies were in vitro, and one was a randomized controlled trial. All the studies reported that bromelain has excellent antimicrobial activity against E. faecalis.; Conclusion: Bromelain extract has a promising role as a root canal irrigant or medication due to its effective antimicrobial effects against E. faecalis. However, as most of the studies are conducted in vitro, there is a need to conduct more in vitro studies on the human infected canals to draw definitive conclusions for their definitive role in endodontics.; (Copyright: © 2025 Journal of Conservative Dentistry and Endodontics.) |
| Competing Interests: | There are no conflicts of interest. |
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| Contributed Indexing: | Keywords: Antimicrobial effects; Enterococcus faecalis; bromelain; pineapple extract; systematic review |
| Entry Date(s): | Date Created: 20251031 Date Completed: 20251031 Latest Revision: 20251102 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC12571467 |
| DOI: | 10.4103/JCDE.JCDE_400_25 |
| PMID: | 41169770 |
| Database: | MEDLINE |
Journal Article; Review