Succinate Dehydrogenase Pathogenic Variants Among Older Adults With Head and Neck Paragangliomas.
| Title: | Succinate Dehydrogenase Pathogenic Variants Among Older Adults With Head and Neck Paragangliomas. |
|---|---|
| Authors: | Bellamkonda N; Department of Otolaryngology - Head and Neck Surgery Huntsman Cancer Institute, University of Utah Salt Lake City Utah USA.; Naumer A; Genetic Counseling Shared Resource Huntsman Cancer Institute, University of Utah Salt Lake City Utah USA.; Buchmann LO; Department of Otolaryngology - Head and Neck Surgery Huntsman Cancer Institute, University of Utah Salt Lake City Utah USA.; McCrary HC; Department of Otolaryngology - Head and Neck Surgery Huntsman Cancer Institute, University of Utah Salt Lake City Utah USA.; Espahbodi M; Department of Otolaryngology - Head and Neck Surgery Huntsman Cancer Institute, University of Utah Salt Lake City Utah USA.; Patel NS; Department of Otolaryngology - Head and Neck Surgery Huntsman Cancer Institute, University of Utah Salt Lake City Utah USA. |
| Source: | Laryngoscope investigative otolaryngology [Laryngoscope Investig Otolaryngol] 2025 Nov 11; Vol. 10 (6), pp. e70302. Date of Electronic Publication: 2025 Nov 11 (Print Publication: 2025). |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Wiley Country of Publication: United States NLM ID: 101684963 Publication Model: eCollection Cited Medium: Print ISSN: 2378-8038 (Print) Linking ISSN: 23788038 NLM ISO Abbreviation: Laryngoscope Investig Otolaryngol Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: [Hoboken, NJ] : Wiley, [2016]- |
| Abstract: | Introduction: The objective of this study was to determine the proportion of patients over the age of 50 who have HNPGL related to an SDH PV.; Methods: Patients seen at a single, tertiary-care academic medical center diagnosed with a new HNPGL over the age of 50 were included and analyzed.; Results: One hundred and eleven individuals (155 tumors) were included. Eighty (72%) patients underwent genetic testing. Twenty-one PVs of known significance were identified (SDHA in 1, SDHB in 11, SDHC in 5, SDHD in 3, and FH in 1). The rate of SDH PVs in the tested group was 25%. The median age in patients with a PV was 60 years (IQR: 54-67) years, compared to 67 years (IQR: 59-71) in those without.; Conclusions: Patients diagnosed with a HNPGL over the age of 50 are still at risk for having an SDH PV. Older patients with HNPGL and their families should still be referred for genetic testing.; Level of Evidence: IV.; (© 2025 The Author(s). Laryngoscope Investigative Otolaryngology published by Wiley Periodicals LLC on behalf of The Triological Society.) |
| Competing Interests: | Neil S. Patel, MD, serves as a consultant for Viridian Therapeutics, has received research support from Cochlear Corp., and has functioned as a speaker on behalf of IotaMotion and Zeiss.The authors declare no conflicts of interest. |
| Comments: | Erratum in: Laryngoscope Investig Otolaryngol. 2026 Jan 22;11(1):e70347. doi: 10.1002/lio2.70347.. (PMID: 41583577) |
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| Grant Information: | P30 CA042014 United States CA NCI NIH HHS |
| Contributed Indexing: | Keywords: SDH; carotid body tumors; glomus tympanicum (middle ear paraganglioma); jugular paragangliomas; paraganglioma |
| Entry Date(s): | Date Created: 20251114 Date Completed: 20251114 Latest Revision: 20260126 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC12606041 |
| DOI: | 10.1002/lio2.70302 |
| PMID: | 41234330 |
| Database: | MEDLINE |
Journal Article