Adherence to clinical guideline recommendation for anticoagulation therapy among Ethiopian patients with atrial fibrillation eligible for thromboembolism prophylaxis: a systematic review and meta-analysis.
| Title: | Adherence to clinical guideline recommendation for anticoagulation therapy among Ethiopian patients with atrial fibrillation eligible for thromboembolism prophylaxis: a systematic review and meta-analysis. |
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| Authors: | Addisu ZD; Department of Clinical Pharmacy, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, Ethiopia.; Yazie TS; Department of Pharmacy, Pharmacology and Toxicology Unit, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.; Tafere C; Department of Pharmaceutics, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, Ethiopia.; Zewdie S; Department of Pharmacy, College of Medicine and Health Science, Injibara University, Injibara, Ethiopia.; Siraj EA; Department of Pharmaceutics, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, Ethiopia.; Beyene DA; Department of Pharmacy, College of Medicine and Health Sciences, Debre Birhan University, Debre Birhan, Ethiopia.; Yismaw MB; Department of Clinical Pharmacy, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, Ethiopia.; Demsie DG; Department of Pharmacology, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, Ethiopia. |
| Source: | Expert review of cardiovascular therapy [Expert Rev Cardiovasc Ther] 2025 Dec; Vol. 23 (12), pp. 923-933. Date of Electronic Publication: 2025 Nov 21. |
| Publication Type: | Systematic Review; Journal Article; Meta-Analysis |
| Language: | English |
| Journal Info: | Publisher: Taylor & Francis Country of Publication: England NLM ID: 101182328 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-8344 (Electronic) Linking ISSN: 14779072 NLM ISO Abbreviation: Expert Rev Cardiovasc Ther Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2015- : Abingdon, Oxford : Taylor & Francis; Original Publication: London, UK : Future Drugs Ltd. |
| MeSH Terms: | Anticoagulants*/administration & dosage ; Atrial Fibrillation*/drug therapy ; Atrial Fibrillation*/complications ; Thromboembolism*/prevention & control ; Thromboembolism*/etiology ; Guideline Adherence*; Humans ; Ethiopia ; Practice Guidelines as Topic ; Administration, Oral |
| Abstract: | Objectives: This systematic review and meta-analysis focused on summarizing and quantitatively estimating the pooled adherence rates to clinical guideline recommendations for anticoagulation therapy in patients with AF receiving treatment in Ethiopian hospitals.; Methods: The Systematic literature search was conducted in PubMed, Cochrane Library, Africa-specific databases (African Index Medicus, and African Journals Online), and Google Scholar. Data were extracted in a structured format prepared using Microsoft Excel. The extracted data were exported to R software Version 4.3.0 for analysis. The I2 test was used to check the heterogeneity between primary studies with a corresponding 95% confidence interval (CI). Based on the test result, a random-effects meta-analysis model was used to estimate pooled effect adherence rate to the international guideline in antithrombotic therapy.; Results: The review included a total of 6 primary studies with the pooled adherence rate to guidelines in antithrombotic therapy use in patients diagnosed with AF who are at high risk for thromboembolic events and eligible for oral anticoagulants was found to be 55% (95% CI: 33% to 77%).; Conclusion: Guideline adherence for oral antithrombotic therapy was low (55%), leaving many high-risk patients vulnerable. Multifaceted interventions, including coordinated care and pharmacist involvement, are needed to improve adherence. |
| Contributed Indexing: | Keywords: Atrial fibrillation; adherence; adherence to guidelines; anticoagulation; thromboembolism |
| Substance Nomenclature: | 0 (Anticoagulants) |
| Entry Date(s): | Date Created: 20251115 Date Completed: 20251212 Latest Revision: 20260105 |
| Update Code: | 20260130 |
| DOI: | 10.1080/14779072.2025.2591312 |
| PMID: | 41239856 |
| Database: | MEDLINE |
Systematic Review; Journal Article; Meta-Analysis