Factors related to mortality in patients with acute respiratory distress syndrome (ARDS) in a lower middle-income country: A retrospective observational study.
| Title: | Factors related to mortality in patients with acute respiratory distress syndrome (ARDS) in a lower middle-income country: A retrospective observational study. |
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| Authors: | Dao CX; Center for Critical Care Medicine, Bach Mai Hospital, Hanoi, Vietnam.; Department of Emergency and Critical Care Medicine, Hanoi Medical University, Hanoi, Vietnam.; Department of Emergency and Critical Care Medicine, Faculty of Medicine, VNU University of Medicine and Pharmacy, Vietnam National University, Hanoi, Vietnam.; Luong CQ; Department of Emergency and Critical Care Medicine, Hanoi Medical University, Hanoi, Vietnam.; Department of Emergency and Critical Care Medicine, Faculty of Medicine, VNU University of Medicine and Pharmacy, Vietnam National University, Hanoi, Vietnam.; Neuro Intensive Care Department, Neurology Center, Bach Mai Hospital, Hanoi, Vietnam.; Manabe T; Nagoya City University School of Data Science, Nagoya, Aichi, Japan.; Center for Clinical Research, Nagoya City University Hospital, Nagoya, Aichi, Japan.; Nguyen MH; Department of Health Organization and Management, Faculty of Public Health, Thai Binh University of Medicine and Pharmacy, Hung Yen, Vietnam.; Pham DT; Department of Nutrition and Food Safety, Faculty of Public Health, Thai Binh University of Medicine and Pharmacy, Hung Yen, Vietnam.; Pham QT; Department of Emergency and Critical Care Medicine, Hanoi Medical University, Hanoi, Vietnam.; Intensive Care Unit, University Medical Center Ho Chi Minh City, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.; Vu TT; Department of Emergency and Critical Care Medicine, Hanoi Medical University, Hanoi, Vietnam.; Emergency Department, Thai Nguyen National Hospital, Thai Nguyen, Vietnam.; Truong HT; Center for Critical Care Medicine, Bach Mai Hospital, Hanoi, Vietnam.; Department of Emergency and Critical Care Medicine, Hanoi Medical University, Hanoi, Vietnam.; Neuro Intensive Care Department, Neurology Center, Bach Mai Hospital, Hanoi, Vietnam.; Khuong DQ; Department of Emergency and Critical Care Medicine, Hanoi Medical University, Hanoi, Vietnam.; Center for Emergency Medicine, Bach Mai Hospital, Hanoi, Vietnam.; Dang HD; Center for Critical Care Medicine, Bach Mai Hospital, Hanoi, Vietnam.; Nguyen TA; Department of Emergency and Critical Care Medicine, Hanoi Medical University, Hanoi, Vietnam.; Center for Emergency Medicine, Bach Mai Hospital, Hanoi, Vietnam.; Pham TT; Center for Critical Care Medicine, Bach Mai Hospital, Hanoi, Vietnam.; Department of Emergency and Critical Care Medicine, Hanoi Medical University, Hanoi, Vietnam.; Department of Emergency and Critical Care Medicine, Faculty of Medicine, VNU University of Medicine and Pharmacy, Vietnam National University, Hanoi, Vietnam.; Bui GTH; Center for Critical Care Medicine, Bach Mai Hospital, Hanoi, Vietnam.; Department of Emergency and Critical Care Medicine, Hanoi Medical University, Hanoi, Vietnam.; Bui CV; Department of Emergency and Critical Care Medicine, Hanoi Medical University, Hanoi, Vietnam.; Department of Emergency and Critical Care Medicine, Faculty of Medicine, VNU University of Medicine and Pharmacy, Vietnam National University, Hanoi, Vietnam.; Department of Intensive Care for Tropical Diseases, Bach Mai Institute for Tropical Medicine, Bach Mai Hospital, Hanoi, Vietnam.; Nguyen QH; Department of Emergency and Critical Care Medicine, Hanoi Medical University, Hanoi, Vietnam.; Department of Emergency and Critical Care Medicine, Faculty of Medicine, VNU University of Medicine and Pharmacy, Vietnam National University, Hanoi, Vietnam.; Center for Emergency Medicine, Bach Mai Hospital, Hanoi, Vietnam.; Tran TH; Department of Emergency and Critical Care Medicine, Hanoi Medical University, Hanoi, Vietnam.; Department of Emergency and Critical Care Medicine, Faculty of Medicine, VNU University of Medicine and Pharmacy, Vietnam National University, Hanoi, Vietnam.; Center for Emergency Medicine, Bach Mai Hospital, Hanoi, Vietnam.; Nguyen TC; Center for Critical Care Medicine, Bach Mai Hospital, Hanoi, Vietnam.; Department of Emergency and Critical Care Medicine, Hanoi Medical University, Hanoi, Vietnam.; Department of Emergency and Critical Care Medicine, Faculty of Medicine, VNU University of Medicine and Pharmacy, Vietnam National University, Hanoi, Vietnam.; Vo KH; Emergency Neurology Room, Neurology Center, Bach Mai Hospital, Hanoi, Vietnam.; Department of Neurology, Hanoi Medical University, Hanoi, Vietnam.; Department of Neurology, Faculty of Medicine, VNU University of Medicine and Pharmacy, Vietnam National University, Hanoi, Vietnam.; Vu LT; Department of Emergency and Critical Care Medicine, Hanoi Medical University, Hanoi, Vietnam.; Center for Emergency Medicine, Bach Mai Hospital, Hanoi, Vietnam.; Phan NT; Department of Health Organization and Management, Faculty of Public Health, Thai Binh University of Medicine and Pharmacy, Hung Yen, Vietnam.; Vu LT; Department of Nutrition and Food Safety, Faculty of Public Health, Thai Binh University of Medicine and Pharmacy, Hung Yen, Vietnam.; Nguyen CD; Department of Emergency and Critical Care Medicine, Thai Binh University of Medicine and Pharmacy, Hung Yen, Vietnam.; Vu TT; Department of Basic Medical Sciences, VNU University of Medicine and Pharmacy, Vietnam National University, Hanoi, Vietnam.; Nguyen AD; Department of Emergency and Critical Care Medicine, Hanoi Medical University, Hanoi, Vietnam.; Center for Emergency Medicine, Bach Mai Hospital, Hanoi, Vietnam.; Nguyen CV; Department of Emergency and Critical Care Medicine, Hanoi Medical University, Hanoi, Vietnam.; Center for Emergency Medicine, Bach Mai Hospital, Hanoi, Vietnam.; Dang TQ; Center for Critical Care Medicine, Bach Mai Hospital, Hanoi, Vietnam.; Department of Emergency and Critical Care Medicine, Hanoi Medical University, Hanoi, Vietnam.; Nguyen BG; Center for Critical Care Medicine, Bach Mai Hospital, Hanoi, Vietnam.; Department of Pre-Hospital Emergency Medicine, Faculty of Medicine, VNU University of Medicine and Pharmacy, Vietnam National University, Hanoi, Vietnam.; Do SN; Center for Critical Care Medicine, Bach Mai Hospital, Hanoi, Vietnam.; Department of Emergency and Critical Care Medicine, Hanoi Medical University, Hanoi, Vietnam.; Department of Emergency and Critical Care Medicine, Faculty of Medicine, VNU University of Medicine and Pharmacy, Vietnam National University, Hanoi, Vietnam. |
| Source: | PloS one [PLoS One] 2025 Nov 18; Vol. 20 (11), pp. e0337071. Date of Electronic Publication: 2025 Nov 18 (Print Publication: 2025). |
| Publication Type: | Journal Article; Observational Study |
| Language: | English |
| Journal Info: | Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: San Francisco, CA : Public Library of Science |
| MeSH Terms: | Respiratory Distress Syndrome*/mortality ; Respiratory Distress Syndrome*/therapy; Vietnam/epidemiology ; Humans ; Male ; Female ; Middle Aged ; Retrospective Studies ; Hospital Mortality ; Aged ; Adult ; Respiration, Artificial ; Risk Factors |
| Abstract: | Background: Acute respiratory distress syndrome (ARDS) is associated with a high mortality rate, particularly in low- and middle-income countries, where the quality of pre-hospital or inter-hospital care can significantly impact patient outcomes. This study aimed to investigate mortality rates and associated factors among ARDS patients in Vietnam.; Methods: This retrospective observational study included adult ARDS patients admitted to a central hospital in Vietnam from August 2015 to August 2023. Data was collected on inter-hospital care, patient characteristics, management, and outcomes; comparisons were made between survivors and non-survivors, and logistic regression analyses were performed to identify factors independently associated with hospital mortality.; Results: Of 353 patients, 68.0% were male, the median age was 55.0 years (Q1-Q3: 39.0-66.0), and 61.5% died in the hospital. The majority of patients (89.5%; 316/353) were transferred from local hospitals, and 80.6% (253/314) had received non-invasive or invasive mechanical ventilation (MV) at the referring hospital. During transportation, 60.1% (116/193) had an endotracheal tube (ET) in place, and 25.6% (41/160) received non-invasive or invasive MV. Upon admission, the mean PaO2/FiO2 ratio was 110.04 mmHg (SD: 57.72), and the median Sequential Organ Failure Assessment (SOFA) score was 10.0 (Q1-Q3: 7.0-12.0). Most patients (95.7%; 315/329) received invasive MV on the first day of admission, and 36.7% (73/199) underwent cytokine adsorption during their hospital stay. The univariable logistic regression identified several factors significantly associated with hospital mortality, including age (OR: 1.027; 95% CI: 1.013-1.040; p |
| Competing Interests: | The authors have declared that no competing interests exist. |
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| Entry Date(s): | Date Created: 20251118 Date Completed: 20251118 Latest Revision: 20251212 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC12626306 |
| DOI: | 10.1371/journal.pone.0337071 |
| PMID: | 41252414 |
| Database: | MEDLINE |
Journal Article; Observational Study