Phytochemical investigation of Crinum asiaticum L.: isolation and characterisation of a new dimeric alkaloid and evaluation of acetylcholinesterase inhibition with molecular docking.
| Title: | Phytochemical investigation of Crinum asiaticum L.: isolation and characterisation of a new dimeric alkaloid and evaluation of acetylcholinesterase inhibition with molecular docking. |
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| Authors: | Lien LQ; Institute of Chemistry, Vietnam Academy of Science and Technology, Hanoi, Vietnam.; Vinh LB; Faculty of Medicine and Pharmacy, Yersin University of Da Lat, Lamdong, Vietnam.; Trang VT; Center for High Technology Research and Development (CHTRD), Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam.; Graduate University of Science and Technology, VAST, Hanoi, Vietnam.; Duc NV; Center for High Technology Research and Development (CHTRD), Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam.; Phong NV; Department of Biology Education, Teachers College and Institute for Phylogenomics and Evolution, Kyungpook National University, Daegu, Republic of Korea.; Yang SY; Department of Biology Education, Teachers College and Institute for Phylogenomics and Evolution, Kyungpook National University, Daegu, Republic of Korea.; Department of Advanced Bioconvergence, BK21 FOUR KNU Center for Innovative One-Health Leaders, Kyungpook National University, Daegu, Republic of Korea.; Trang NM; College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea.; Hieu NV; Center for High Technology Research and Development (CHTRD), Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam.; Tuan DT; Thai Binh University of Medicine and Pharmacy, Thai Binh, Vietnam.; Dat NT; Center for High Technology Research and Development (CHTRD), Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam.; Linh TM; Institute of Chemistry, Vietnam Academy of Science and Technology, Hanoi, Vietnam.; Hoe PT; Institute of Chemistry, Vietnam Academy of Science and Technology, Hanoi, Vietnam.; Tuan Anh HL; Center for High Technology Research and Development (CHTRD), Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam.; Graduate University of Science and Technology, VAST, Hanoi, Vietnam. |
| Source: | Natural product research [Nat Prod Res] 2025 Nov 24, pp. 1-11. Date of Electronic Publication: 2025 Nov 24. |
| Publication Model: | Ahead of Print |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Taylor & Francis Health Sciences Country of Publication: England NLM ID: 101167924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1478-6427 (Electronic) Linking ISSN: 14786419 NLM ISO Abbreviation: Nat Prod Res Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Milton Park, UK : Taylor & Francis Health Sciences, c2003- |
| Abstract: | Crinum asiaticum L. (Amaryllidaceae) is a perennial bulbous plant commonly used for its various pharmacological benefits, such as anticancer, immune-boosting, pain-relieving, antiviral, antimalarial, antibacterial, and antifungal properties, while also being appreciated for its ornamental value. A phytochemical investigation of the bulbs of C. asiaticum resulted in the isolation of a new dimeric alkaloid, bis-(-)-8-demethylepimaritidine (1) together with five known compounds, lycorine (2), 3-O-acetyl-8-O-demethylmaritidine (3), (-)-siculine (4), (-)-8-demethylmaritidine (5), and (4aα,5β,10bβ)-4,4a-dihydro-9-methoxy-3H,6H-5,10b-ethanophenanthridine-3,10-diol (6). Structural elucidation of all the compounds was performed by spectral methods such as 1D and 2D NMR as well as HR-ESI-MS analysis. The absolute configuration of 1 was determined by CD spectrum. All isolates were in vitro evaluated for their acetylcholinesterase (AChE) inhibitory activities. Additionally, molecular docking analyses were conducted to investigate the interactions between the active compound and AChE, and to evaluate its binding affinity, thereby revealing the underlying mechanisms of enzyme inhibition. |
| Contributed Indexing: | Keywords: AChE; Crinum asiaticum L.; alkaloid; alzheimer’s disaease |
| Entry Date(s): | Date Created: 20251124 Latest Revision: 20251124 |
| Update Code: | 20260130 |
| DOI: | 10.1080/14786419.2025.2592267 |
| PMID: | 41284967 |
| Database: | MEDLINE |
Journal Article