Burn injuries in the Asia-Pacific region: Use of polyhexamethylene biguanide and betaine surfactant (PHMB-B) for wound bed preparation in children and adults.
| Title: | Burn injuries in the Asia-Pacific region: Use of polyhexamethylene biguanide and betaine surfactant (PHMB-B) for wound bed preparation in children and adults. |
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| Authors: | Nair HK; Professor of Wound Care, Faculty of Medicine, Lincoln University; President, World Union of Wound Healing Societies; Director, Kuala Lumpur Hospital, Kuala Lumpur, Malaysia.; Muangman P; Professor of Surgery, Siriraj Hospital, Thailand.; Liu Y; Professor of Surgery, Siriraj Hospital, Thailand.; Coleman K; Nurse Practitioner and Founder, All Wrapped Up Nursing Consultative Service, Australia.; Kanpuan W; Nakornping Hospital, Chiang Mai, Thailand.; Suondoh MS; Kuala Lumpur General Hospital, Kuala Lumpur, Malaysia.; Sukur SM; Kuala Lumpur General Hospital, Kuala Lumpur, Malaysia.; Ketmek A; Siriraj Hospital, Bangkok, Thailand.; Tianwattanatada S; Siriraj Hospital, Bangkok, Thailand.; Kittidacha S; Siriraj Hospital, Bangkok, Thailand.; Taengthet O; Siriraj Hospital, Bangkok, Thailand.; Wang WL; Ruijin Hospital, affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Gao M; Ruijin Hospital, affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Yin ZQ; Ruijin Hospital, affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Dou Y; Ruijin Hospital, affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Zhu JJ; Ruijin Hospital, affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Song C; Ruijin Hospital, affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Zhang G; Ruijin Hospital, affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Li X; Ruijin Hospital, affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Yang H; Ruijin Hospital, affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Van Phu D; Le Huu Trac National Burn Hospital, Hanoi, Vietnam.; An NH; Le Huu Trac National Burn Hospital, Hanoi, Vietnam.; Lukban CRB; Philippine General Hospital, Manila, the Philippines.; Abesamis GMM; Philippine General Hospital, Manila, the Philippines.; Santamaria RV; Philippine General Hospital, Manila, the Philippines.; Acance FA; Philippine General Hospital, Manila, the Philippines.; Yadi DA; Hasan Sadikin Hospital Bandung, West Java, Indonesia.; Ganefianty A; Hasan Sadikin Hospital Bandung, West Java, Indonesia.; Hakim A; Hasan Sadikin Hospital Bandung, West Java, Indonesia.; Angulugaha CS; National Hospital of Sri Lanka, Colombo, Sri Lanka.; Ekanayake G; National Hospital of Sri Lanka, Colombo, Sri Lanka.; Wimalarathna S; National Hospital of Sri Lanka, Colombo, Sri Lanka.; Suondoh MS; Kuala Lumpur General Hospital, Kuala Lumpur, Malaysia.; Sukur SM; Kuala Lumpur General Hospital, Kuala Lumpur, Malaysia.; Sawangsangwattana T; Bangkok Metropolitan Administration (Klang) Hospital, Bangkok, Thailand.; Wattanakham T; Bangkok Metropolitan Administration (Klang) Hospital, Bangkok, Thailand.; Ganbat A; National Trauma & Orthopedic Research Center of Mongolia, Ulaanbaatar, Mongolia. |
| Source: | Journal of wound care [J Wound Care] 2025 Dec 01; Vol. 34 (Sup12c), pp. S1-S20. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: MA Healthcare Country of Publication: England NLM ID: 9417080 Publication Model: Print Cited Medium: Internet ISSN: 0969-0700 (Print) Linking ISSN: 09690700 NLM ISO Abbreviation: J Wound Care Subsets: MEDLINE |
| Imprint Name(s): | Publication: London : MA Healthcare; Original Publication: Ruislip, UK : Journal of Wound Care |
| MeSH Terms: | Biguanides*/therapeutic use ; Burns*/therapy ; Burns*/drug therapy ; Betaine*/therapeutic use ; Surface-Active Agents*/therapeutic use ; Anti-Infective Agents, Local*/therapeutic use; Wound Healing/drug effects ; Humans ; Adult ; Child ; Asia ; Male ; Female |
| Abstract: | This case-series supplement serves as an educational resource for health professionals involved in the care of burn injuries. Drawing from clinical experiences across healthcare settings in the Asia-Pacific region, the supplement focuses on the use of polyhexamethylene biguanide and betaine surfactant (PHMB-B) solution, gel and high-viscosity gel, alone or in combination, in managing both thermal and non-thermal burns, including partial-thickness and full-thickness burns, in both paediatric and adult populations. In alignment with international guidance, this supplement reinforces the recommendation to integrate PHMB-B into routine practice. The broad-spectrum antimicrobial activity, low cytotoxicity and biofilm-disruptive properties of this combined solution is clinically appropriate for use in complex burn wounds, where infection control and optimal healing conditions are crucial to wound healing. |
| Substance Nomenclature: | 0 (Biguanides); 322U039GMF (polihexanide); 3SCV180C9W (Betaine); 0 (Surface-Active Agents); 0 (Anti-Infective Agents, Local) |
| Entry Date(s): | Date Created: 20251204 Date Completed: 20251204 Latest Revision: 20251204 |
| Update Code: | 20260130 |
| DOI: | 10.12968/jowc.2025.34.Sup12c.S1 |
| PMID: | 41343257 |
| Database: | MEDLINE |
Journal Article