Epidemiology and severity risk factors of dengue virus infection during the 2023-2024 outbreak in Colombia.
| Title: | Epidemiology and severity risk factors of dengue virus infection during the 2023-2024 outbreak in Colombia. |
|---|---|
| Authors: | Torres-Hernández D; Department of Pediatrics, Universidad del Valle, Cali, Colombia.; Grubaugh ND; Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut, United States of America.; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut, United States of America.; Murillo-Ortiz MA; Hospital Universitario del Valle. Cali, Colombia.; School of Bacteriology, Universidad del Valle, Cali, Colombia.; Hurtado IC; Department of Pediatrics, Universidad del Valle, Cali, Colombia.; Hospital Universitario del Valle. Cali, Colombia.; State Department of Public Health, Valle del Cauca, Colombia.; Hill V; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut, United States of America.; Breban MI; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut, United States of America.; Gómez-Zambrano M; Department of Pediatrics, Universidad del Valle, Cali, Colombia.; López P; Department of Pediatrics, Universidad del Valle, Cali, Colombia.; Department of Scientific Advancement, EndPoints Network of Research Sites, Latin America.; Cantor E; Department of Clinical Epidemiology and Biostatistics, Pontificia Universidad Javeriana, Bogotá, Colombia.; Dávalos DM; Department of Scientific Advancement, EndPoints Network of Research Sites, Latin America.; López-Medina E; Department of Pediatrics, Universidad del Valle, Cali, Colombia.; Clínica Imbanaco Grupo Quironsalud, Cali, Colombia.; Department of Scientific Advancement, EndPoints Network of Research Sites, Latin America. |
| Source: | PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2025 Dec 05; Vol. 19 (12), pp. e0013115. Date of Electronic Publication: 2025 Dec 05 (Print Publication: 2025). |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Public Library of Science Country of Publication: United States NLM ID: 101291488 Publication Model: eCollection Cited Medium: Internet ISSN: 1935-2735 (Electronic) Linking ISSN: 19352727 NLM ISO Abbreviation: PLoS Negl Trop Dis Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: San Francisco, CA : Public Library of Science |
| MeSH Terms: | Dengue Virus*/genetics ; Dengue Virus*/classification ; Dengue Virus*/isolation & purification ; Dengue*/epidemiology ; Dengue*/virology ; Disease Outbreaks*; Colombia/epidemiology ; Severe Dengue/epidemiology ; Humans ; Male ; Female ; Risk Factors ; Adolescent ; Child ; Adult ; Prospective Studies ; Young Adult ; Child, Preschool ; Middle Aged ; Genotype ; Serogroup ; Infant ; Severity of Illness Index |
| Abstract: | Introduction: During 2023-2024, the Americas faced its largest dengue epidemic to date. We used a detailed dengue classification to identify patients with serious manifestations of dengue and aimed to describe risk factors for occurrence.; Methods: From April 2023 to September 2024, we conducted a prospective in-hospital active case-finding cohort study at the Hospital Universitario del Valle (HUV) in Colombia, enrolling patients of all ages with virologically confirmed dengue (VCD). Sociodemographic and clinical data were collected, and the dengue virus (DENV) genome was sequenced for serotyping and genotyping. Multivariable logistic regression modeling identified factors associated with "serious manifestations of dengue", defined as severe dengue (2009 WHO classification) or dengue with warning signs (DwWS) with a more severe course, including vascular leakage (increases in hematocrit >20%, pleural effusion or ascites with hemodynamic/respiratory compromise); bleeding with hemodynamic instability or requiring blood transfusion; thrombocytopenia |
| Competing Interests: | I have read the journal’s policy and the authors of this manuscript have the following competing interests: ELM and/or his institution have received research grants from Takeda, MSD, Sanofi Pasteur, Janssen, and GSK, and speaker honoraria from Takeda, MSD, Sanofi Pasteur, and GSK. |
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| Grant Information: | DP2 AI176740 United States AI NIAID NIH HHS; S10 OD028669 United States OD NIH HHS |
| Entry Date(s): | Date Created: 20251205 Date Completed: 20251210 Latest Revision: 20251213 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC12694831 |
| DOI: | 10.1371/journal.pntd.0013115 |
| PMID: | 41348908 |
| Database: | MEDLINE |
Journal Article