Assessing cancer-related mortality risk among people with HIV in Vietnam: A nationwide population study.
| Title: | Assessing cancer-related mortality risk among people with HIV in Vietnam: A nationwide population study. |
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| Authors: | Le NT; Department of Clinical Research, Vinmec Healthcare System, Hanoi, Vietnam.; Institute of Research and Development, Duy Tan University, Da Nang, Vietnam.; Ta ND; Department of Infectious Diseases, Hanoi Medical University, Hanoi, Vietnam.; Vu TT; General Daycare Inpatient Department, Hanoi Oncology Hospital, Hanoi, Vietnam.; Tran KX; Hung Yen Hospital of Tropical Diseases, Hung Yen, Vietnam.; Bui TC; Department of Family and Preventive Medicine, College of Medicine, University of Oklahoma Health Campus, Oklahoma City, Oklahoma, USA.; TSET Health Promotion Research Center, Stephenson Cancer Center, University of Oklahoma Health Campus, Oklahoma City, Oklahoma, USA.; Liu H; Department of Epidemiology and Biostatistics, School of Public Health, University of Maryland, College Park, Maryland, USA.; Ha T; Department of Infectious Diseases and Microbiology, School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. |
| Source: | HIV medicine [HIV Med] 2026 Mar; Vol. 27 (3), pp. 433-441. Date of Electronic Publication: 2025 Dec 06. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Wiley Country of Publication: England NLM ID: 100897392 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1468-1293 (Electronic) Linking ISSN: 14642662 NLM ISO Abbreviation: HIV Med Subsets: MEDLINE |
| Imprint Name(s): | Publication: Oxford : Wiley; Original Publication: Oxford : Blackwell Science, c1999- |
| MeSH Terms: | HIV Infections*/complications ; HIV Infections*/epidemiology ; HIV Infections*/mortality ; Neoplasms*/mortality; Vietnam/epidemiology ; Humans ; Male ; Female ; Adult ; Middle Aged ; Young Adult ; Adolescent ; Aged ; Child, Preschool ; Child ; Infant |
| Abstract: | Background: Despite the growing burden of comorbidities, including cancer, among people with HIV, there is a lack of empirical evidence on cancer-related mortality in this vulnerable population in Vietnam.; Objectives: This study aimed to examine cancer mortality rates among people with HIV in Vietnam by cancer type, age and sex and compare them with those in the general population.; Methods: We analysed nationally representative mortality data from 2005 to 2021, collected via Vietnam's mandatory mortality registration system. Cancer deaths and HIV status were identified using the ICD-10 codes. People with HIV data were linked to the Vietnam Ministry of Health HIV/AIDS registry. Mortality rates (per 100 000 person-years) and mortality rate ratios (MRRs) with 95% confidence intervals (CIs) were calculated, stratified by age and sex and age-standardized using the World Health Organization standards.; Results: Among people with HIV, 253 cancer deaths occurred across 523709 person-years (crude rate 48.3 per 100 000 person-years), compared to 173 592 cancer deaths over 272 million person-years in the general population (crude rate 63.8 per 100 000 person-years) between 2005 and 2021. The age-standardized cancer mortality rate among people with HIV was 50.5 per 100 000 person-years, compared with 110.2 per 100 000 person-years in the general population. However, age-specific analysis revealed that cancer mortality rates among people with HIV under age 50 were significantly higher than those in the general population (MRR = 2.29; 95% CI: 2.01-2.59), predominantly for lung cancer (MRR = 10.5; 95% CI: 8.89, 12.41) and liver cancer (MRR = 1.82; 95% CI: 1.38, 2.40). The highest MRR was observed in the youngest age group (1-29 years; MRR = 5.67; 95% CI: 4.63, 6.93).; Conclusion: Although the age-standardized cancer mortality rate among people with HIV was lower than in the general population, people with HIV experience substantially higher cancer mortality among those under age 50, particularly from lung and liver cancers. These findings emphasize the urgent need for integrated cancer prevention, early detection and treatment strategies for people with HIV in Vietnam.; (© 2025 British HIV Association.) |
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| Grant Information: | HSS100 Australian Government; P30CA225520 National Cancer Institute, USA; STCST00400_FY25 Oklahoma Tobacco Settlement Endowment Trust; University of Pittsburgh School of Public Health: Start-up Funds |
| Contributed Indexing: | Keywords: HIV/AIDS; Vietnam; cancer risk; people with HIV |
| Entry Date(s): | Date Created: 20251206 Date Completed: 20260309 Latest Revision: 20260309 |
| Update Code: | 20260309 |
| DOI: | 10.1111/hiv.70161 |
| PMID: | 41351355 |
| Database: | MEDLINE |
Journal Article